Search Results - "TESTA, Jacqueline E"

In vivo proteomic imaging analysis of caveolae reveals pumping system to penetrate solid tumors by Oh, Phil, Testa, Jacqueline E, Borgstrom, Per, Witkiewicz, Halina, Li, Yan, Schnitzer, Jan E

“…Proteomic-imaging analysis of caveolae shows active transvascular pumping of antibodies across the endothelial cell barrier and into solid tumors against a…”
Get full text

Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung by Schnitzer, Jan E, Oh, Phil, Borgström, Per, Witkiewicz, Halina, Li, Yan, Borgström, Bengt J, Chrastina, Adrian, Iwata, Koji, Zinn, Kurt R, Baldwin, Richard, Testa, Jacqueline E

“…How effectively and quickly endothelial caveolae can transcytose in vivo is unknown, yet critical for understanding their function and potential clinical…”
Get full text

Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and in cell culture by Schnitzer, Jan E, Durr, Eberhard, Yu, Jingyi, Krasinska, Karolina M, Carver, Lucy A, Yates, John R, Testa, Jacqueline E, Oh, Phil

“…Endothelial cells can function differently in vitro and in vivo; however, the degree of microenvironmental modulation in vivo remains unknown at the molecular…”
Get full text

Screening Phage Display Libraries for Organ-Specific Vascular Immunotargeting in vivo by Valadon, Philippe, Garnett, Jeff D., Testa, Jacqueline E., Bauerle, Marc, Oh, Phil, Schnitzer, Jan E.

“…The molecular diversity of the luminal endothelial cell surface arising in vivo from local variations in genetic expression and tissue microenvironment may…”
Get full text

Subtractive immunization using highly metastatic human tumor cells identifies SIMA135 CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen by HOOPER, John D, ZIJLSTRA, Andries, AIMES, Ronald T, HONGYAN LIANG, CLAASSEN, Gisela F, TARIN, David, TESTA, Jacqueline E, QUIGLEY, James P

“…We have previously used a subtractive immunization (SI) approach to generate monoclonal antibodies (mAbs) against proteins preferentially expressed by the…”
Get full text

Immunotargeting and cloning of two CD34 variants exhibiting restricted expression in adult rat endothelia in vivo by Testa, Jacqueline E, Chrastina, Adrian, Oh, Phil, Li, Yan, Witkiewicz, Halina, Czarny, Malgorzata, Buss, Tim, Schnitzer, Jan E

“…Mapping protein expression of endothelial cells (EC) in vivo is fundamental to understanding cellular function and may yield new tissue-selective targets. We…”
Get more information

Ubiquitous yet distinct expression of podocalyxin on vascular surfaces in normal and tumor tissues in the rat by Testa, Jacqueline E, Chrastina, Adrian, Li, Yan, Oh, Phil, Schnitzer, Jan E

“…The vasculature has become an important target in the development of therapies for increasing numbers of human diseases, yet there are few reliable markers…”
Get more information

Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy by Schnitzer, Jan E, Oh, Phil, Li, Yan, Yu, Jingyi, Durr, Eberhard, Krasinska, Karolina M, Carver, Lucy A, Testa, Jacqueline E

“…The molecular complexity of tissues and the inaccessibility of most cells within a tissue limit the discovery of key targets for tissue-specific delivery of…”
Get full text

Introduction of an RRHR Motif into Chicken Urokinase-Type Plasminogen Activator (Ch-uPA) Confers Sensitivity to Plasminogen Activator Inhibitor (PAI)-1 and PAI-2 and Allows ch-uPA-Mediated Extracellular Matrix Degradation to be controlled PAI-1 by Sipley, John D., Alexander, Daniela S., Testa, Jacqueline E., Quigley, James P.

“…Comparison of the amino acid sequence of the chicken and human workinase-type plasminogen activators (uPAs) revealed that the putative PAI-binding site found…”
Get full text

Targeting the proteome/epitome, implementation of subtractive immunization by Zijlstra, Andries, Testa, Jacqueline E, Quigley, James P

“…Monoclonal antibody technology has generated invaluable tools for both the analytical and clinical sciences. However, standard immunization approaches…”
Get full text

Loss of the metastatic phenotype by a human epidermoid carcinoma cell line, HEp-3, is accompanied by increased expression of tissue inhibitor of metalloproteinase 2 by TESTA, J. E

“…The human epidermoid carcinoma cell line HEp-3 gives rise to spontaneous metastases in nude mice and in the chick chorioallantoic membrane (CAM) assay system…”
Get full text

Co-inoculation of human and murine carcinoma cells induces reciprocal suppression of metastasis by both cell lines by Nielsen-Preiss, S M, Quigley, J P, Testa, J E

“…The interactions of two cell lines having different metastatic properties, and the subsequent effects on dissemination were investigated using the chicken…”
Get full text

Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis by TESTA, J. E, BROOKS, P. C, LIN, J.-M, QUIGLEY, J. P

“…A monoclonal antibody (mAb), 50-6, generated by subtractive immunization, was found to specifically inhibit in vivo metastasis of a human epidermoid carcinoma…”
Get full text

Erratum: Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung by Oh, Phil, Borgström, Per, Witkiewicz, Halina, Li, Yan, Borgström, Bengt J, Chrastina, Adrian, Iwata, Koji, Zinn, Kurt R, Baldwin, Richard, Testa, Jacqueline E, Schnitzer, Jan E

Get full text

Reversal of misfortune: TIMP-2 inhibits tumor cell invasion by Testa, J E, Quigley, J P

Get more information

158 Chicken plasminogen activator (chuPA): Autoactivating and serpin resistant: A protease out of control by Sipley, John D., Alexander, Daniela S., Testa, Jacqueline E., Mueller, Barbara, Quigley, James P.

Get full text

Protease receptors on cell surfaces: new mechanistic formulas applied to an old problem by Testa, J E, Quigley, J P

Get more information