Search Results - "TENGXIAN LIU"

Contribution of late sodium current (INa-L ) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents by Guo, Donglin, MD, PhD, Lian, Jianfang, MD, PhD, Liu, Tengxian, BS, Cox, Robert, PhD, Margulies, Kenneth B., MD, Kowey, Peter R., MD, Yan, Gan-Xin, MD, PhD

“…Background Abnormal rate adaptation of ventricular repolarization is arrhythmogenic. There is controversy on the underlying ionic mechanisms for rate-dependent…”
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Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: A blinded validation by Liu, Tengxian, BS, Traebert, Martin, PhD, Ju, Haisong, PhD, Suter, Willi, PhD, Guo, Donglin, MD, Hoffmann, Peter, MD, Kowey, Peter R., MD, FHRS, Yan, Gan-Xin, MD, PhD

“…Background The ventricular components (QRS and QT) on the electrocardiogram (ECG) depend on the properties of ventricular action potentials that can be…”
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Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome: Direct evidence from intracellular recordings in the intact left ventricular wall by YAN, Gan-Xin, YING WU, TENGXIAN LIU, JIXIN WANG, MARINCHAK, Roger A, KOWEY, Peter R

“…This study examined the role of phase 2 early afterdepolarization (EAD) in producing a trigger to initiate torsade de pointes (TdP) with QT prolongation…”
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Ventricular hypertrophy amplifies transmural dispersion of repolarization by preferentially increasing the late sodium current in endocardium by Guo, Donglin, MD, PhD, Yu, Mengfei, PhD, Liu, Qinghua, PhD, Cox, Robert H., PhD, Liu, Tengxian, MS, Yan, Gan-Xin, MD, PhD

“…Abstract Background The late sodium current (INa-L ) contributes importantly to rate-dependent change in action potential duration (APD) and transmural…”
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Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbit by Guo, Donglin, Young, Lindon, Patel, Chinmay, Jiao, Zhen, Wu, Ying, Liu, Tengxian, Kowey, Peter R, Yan, Gan-Xin

“…T-wave alternans, characterized by a beat-to-beat change in T-wave morphology, amplitude, and/or polarity on the ECG, often heralds the development of lethal…”
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L-type calcium current recovery versus ventricular repolarization: preserved membrane-stabilizing mechanism for different QT intervals across species by Guo, Donglin, MD, PhD, Zhou, Jun, MD, PhD, Zhao, Xiaojing, MD, Gupta, Prasad, MD, Kowey, Peter R., MD, Martin, Jack, MD, Wu, Ying, Liu, Tengxian, BS, Yan, Gan-Xin, MD, PhD

“…Background Long QT syndrome is associated with early afterdepolarization (EAD) that may result in torsade de pointes (TdP). Interestingly, the corrected QT…”
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Left ventricular hypertrophy decreases slowly but not rapidly activating delayed rectifier potassium currents of epicardial and endocardial myocytes in rabbits by XIAOPING XU, RIALS, Seth J, YING WU, SALATA, Joseph J, TENGXIAN LIU, BHARUCHA, David B, MARINCHAK, Roger A, KOWEY, Peter R

“…Delayed rectifier K(+) currents are critical to action potential (AP) repolarization. The present study examines the effects of left ventricular hypertrophy…”
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Abstract 14031: Effects of Custodiol-HTK and Del Nido Solutions in a Coronary-Perfused Rabbit Ventricular Wedge Model by Sicouri, Serge, Kilcoyne, Maxwell, Yan, Gan-Xin, Liu, Tengxian, Buckley, Meghan, Ramlawi, Basel

“…IntroductionDistinct cardioplegic solutions are used in cardiac surgery for myocardial protection. Custodiol-HTK (CUS) solution consists of histidine,…”
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Utility of Normalized TdP Score System in Drug Proarrhythmic Potential Assessment: A Blinded in vitro Study of CiPA Drugs by Liu, Tengxian, Liu, Jiang, Lu, Hua Rong, Li, Haiyan, Gallacher, David J., Chaudhary, Khuram, Wang, Yaning, Yan, Gan‐Xin

“…Drugs that prolong QT may cause torsade de pointes (TdP). However, translation of nonclinical assessment of QT prolongation or hERG channel, targeted by…”
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Electrophysiologic Effects of SB-237376: A New Antiarrhythmic Compound with Dual Potassium and Calcium Channel Blocking Action by Xu, Xiaoping, Yan, Gan-Xin, Wu, Ying, Liu, Tengxian, Kowey, Peter R

“…Combined potassium and calcium channel blocking activities are suggested to be the basis for antiarrhythmic efficacy with low proarrhythmic risk. The…”
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Restoration of Normal Ventricular Electrophysiology in Renovascular Hypertensive Rabbits after Treatment with Losartan by Rials, Seth J, Xu, Xiaoping, Wu, Ying, Liu, Tengxian, Marinchack, Roger A, Kowey, Peter R

“…Left ventricular hypertrophy (LVH) is associated with abnormal ventricular electrophysiology. We have shown complete regression of LVH and normalization of…”
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GW29-e1186 Determination of Electrophysiological Effects and Cardiac Safety of Three Chinese Herb Monomers by Using the Isolated Rabbit Ventricular Wedge Model by Gao, Yuan, Song, Ge, Zhao, Wenping, Liu, Tengxian, Yan, Ganxin, Wang, Youping, Li, Bin, Zhu, Xinfeng, Xing, Zuoying, Zhu, Mingjun

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How to determine cardiac ion channels targeted by drugs using the isolated rabbit ventricular wedge model by Liu, Guizhi, Liu, Tong, Cohen, Daniel, Liu, Tengxian, Yan, Gan-Xin

“…The rabbit left ventricular wedge (RLVW) has been demonstrated as a highly sensitive and specific preclinical model in assessing drug-induced QT prolongation…”
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Wenxin Keli Suppresses Ventricular Triggered Arrhythmias via Selective Inhibition of Late Sodium Current by XUE, XIAOLIN, GUO, DONGLIN, SUN, HONGMEI, WANG, DAN, LI, JIANA, LIU, TENGXIAN, YANG, LIN, SHU, JUAN, YAN, GAN-XIN

“…Background Wenxin Keli is a popular Chinese herb extract that approximately five million Asians are currently taking for the treatment of a variety of…”
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Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias by Liu, Tengxian, Brown, Barry S, Wu, Ying, Antzelevitch, Charles, Kowey, Peter R, Yan, Gan-Xin

“…The development of preclinical models with high predictive value for the identification of drugs with a proclivity to induce Torsade de Pointes (TdP) in the…”
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Electrophysiological Properties of HBI-3000: A New Antiarrhythmic Agent With Multiple-channel Blocking Properties in Human Ventricular Myocytes by Guo, Donglin, Liu, Que, Liu, Tengxian, Elliott, Gary, Gingras, Mireille, Kowey, Peter R, Yan, Gan-Xin

“…HBI-3000 (sulcardine sulfate) has been shown to suppress various ventricular arrhythmias in animal models. The electrophysiological properties of HBI-3000 were…”
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L-Type Calcium Current Reactivation Contributes to Arrhythmogenesis Associated with Action Potential Triangulation by GUO, DONGLIN, ZHAO, XIAOJING, WU, YING, LIU, TENGXIAN, KOWEY, PETER R., YAN, GAN-XIN

“…Introduction: The morphology of the mammalian cardiac action potential (AP) is an important factor in the susceptibility to drug‐induced early…”
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REVERSE-USE DEPENDENCE OF ANTIARRHYTHMIC DRUGS: ROLE OF LATE SODIUM CURRENT by Patel, Chinmay, Liu, Tengxian, Kowey, Peter R, Yan, Gan-Xin

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Differentiating electrophysiological effects and cardiac safety of drugs based on in vitro electrocardiogram: A blinded validation by Liu, Tengxian, Traebert, Martin, Ju, Haisong, Suter, Willi, Guo, Donglin, Hoffmann, Peter, Kowey, Peter, Yan, Gan-Xin

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Ventricular hypertrophy amplifies transmural repolarization dispersion and induces early afterdepolarization by Yan, G X, Rials, S J, Wu, Y, Liu, T, Xu, X, Marinchak, R A, Kowey, P R

“…The effects of left ventricular hypertrophy (LVH) on the generation of phase 2 early afterdepolarization (EAD) and transmural dispersion of repolarization…”
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