Search Results - "TEMPESTINI, ALESSIO"

Coenzyme Q10 Prevents Apoptosis by Inhibiting Mitochondrial Depolarization Independently of Its Free Radical Scavenging Property by Papucci, Laura, Schiavone, Nicola, Witort, Ewa, Donnini, Martino, Lapucci, Andrea, Tempestini, Alessio, Formigli, Lucia, Zecchi-Orlandini, Sandra, Orlandini, Giovanni, Carella, Giuseppe, Brancato, Rosario, Capaccioli, Sergio

“…The permeability transition pore (PTP) is a mitochondrial channel whose opening causes the mitochondrial membrane potential (ΔΨ) collapse that leads to…”
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Flow-Mediated Vasodilation and Carotid Intima-Media Thickness in Systemic Sclerosis by BARTOLI, FRANCESCA, BLAGOJEVIC, JELENA, BACCI, MARZIA, FIORI, GINEVRA, TEMPESTINI, ALESSIO, CONFORTI, MARIA LETIZIA, GUIDUCCI, SERENA, MINIATI, IRENE, DI CHICCO, MAURO, DEL ROSSO, ANGELA, PERFETTO, FEDERICO, CASTELLANI, SERGIO, PIGNONE, ALBERTO, CERINIC, MARCO MATUCCI

“…:  Increased evidence suggests an accelerated macrovascular disease in systemic sclerosis (SSc). Brachial artery flow‐mediated vasodilation (FMD) and carotid…”
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AUF1 Is a bcl-2 A + U-rich Element-binding Protein Involved in bcl-2 mRNA Destabilization during Apoptosis by Lapucci, Andrea, Donnini, Martino, Papucci, Laura, Witort, Ewa, Tempestini, Alessio, Bevilacqua, Anna, Nicolin, Angelo, Brewer, Gary, Schiavone, Nicola, Capaccioli, Sergio

“…We previously identified a conserved A + U-rich element (ARE) in the 3′-untranslated region of bcl-2mRNA. We have also recently demonstrated that the bcl-2ARE…”
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Exercise Doppler Echocardiography Identifies Preclinic Asymptomatic Pulmonary Hypertension in Systemic Sclerosis by PIGNONE, ALBERTO, MORI, FABIO, PIERI, FRANCESCO, ODDO, ANDREA, GALEOTA, GIANNA, FIORI, GINEVRA, DEL ROSSO, ANGELA, PERFETTO, FEDERICO, BECUCCI, AURELIANO, LIVI, RICCARDO, TEMPESTINI, ALESSIO, BENVENUTI, CHIARA, GRAMIGNA, LEONARDO, FEDI, ROBERTO, GENERINI, SERGIO, MINELLI, MARTINA, CINELLI, MARINA, GUIDUCCI, SERENA, ARCANGELI, CHIARA, LETIZIA CONFORTI, MARIA, BERNARDO, PASQUALE, CERINIC, MARCO MATUCCI

“…:  In systemic sclerosis (SSc), the involvement of the interstitium or vascular system of the lung may lead to pulmonary arterial hypertension (PAH). PAH is…”
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Impact of targeting the adenine- and uracil-rich element of bcl-2 mRNA with oligoribonucleotides on apoptosis, cell cycle, and neuronal differentiation in SHSY-5Y cells by Papucci, Laura, Witort, Ewa, Bevilacqua, Anna Maria, Donnini, Martino, Lulli, Matteo, Borchi, Elisabetta, Khabar, Khalid S A, Tempestini, Alessio, Lapucci, Andrea, Schiavone, Nicola, Nicolin, Angelo, Capaccioli, Sergio

“…We have identified previously a destabilizing adenine- and uracil-rich element (ARE) in the 3'-UTR of bcl-2 mRNA that interacted with ARE-binding proteins to…”
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Downregulation of bcl-2 expression in lymphoma cells by bcl-2 ARE-targeted modified, synthetic ribozyme by Luzi, Ettore, Papucci, Laura, Schiavone, Nicola, Donnini, Martino, Lapucci, Andrea, Tempestini, Alessio, Witort, Ewa, Nicolin, Angelo, Capaccioli, Sergio

“…Synthetic ribozymes are catalytic RNA molecules designed to inhibit gene expression by cleaving specific mRNA sequences. We investigated the potential of…”
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Systemic amyloidosis: a challenge for the rheumatologist by Bergesio, Franco, Matucci-Cerinic, Marco, Tempestini, Alessio, Moggi-Pignone, Alberto, Livi, Riccardo, Perfetto, Federico

“…Amyloidosis is a potential complication of chronic rheumatic diseases, particularly rheumatoid arthritis; in addition, patients with systemic amyloidosis can…”
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Therapeutic challenges for systemic sclerosis: facts and future targets by Cerinic Matucci, M, Del Rosso, Angela, Federico, Perfetto, Livi, Riccardo, Fiori, Ginevra, Bartoli, Francesca, Blagojevic, Jelena, Tempestini, Alessio, Pignone, Alberto

“…Pulmonary arterial hypertension (PAH) is an important cause of death in systemic sclerosis (SSc), despite the improvement of therapies. An early diagnosis and…”
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Reduced circulating levels of angiotensin-(1–7) in systemic sclerosis: a new pathway in the dysregulation of endothelial-dependent vascular tone control by Pignone, Alberto, Rosso, Angela Del, Brosnihan, K Bridget, Perfetto, Federico, Livi, Riccardo, Fiori, Ginevra, Guiducci, Serena, Cinelli, Marina, Rogai, Veronica, Tempestini, Alessio, Bartoli, Francesca, Generini, Sergio, Ferrario, Carlos M, Cerinic, Marco Matucci

“…Objective:Systemic sclerosis (SSc) impairs endothelium-dependent vasodilatation. Among angiotensin I (Ang I)-derived compounds, vasoconstrictor angiotensin II…”
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Melatonin is a safe and effective treatment for chronic pulmonary and extrapulmonary sarcoidosis by Pignone, Alberto Moggi, Rosso, Angela Del, Fiori, Ginevra, Matucci-Cerinic, Marco, Becucci, Aureliano, Tempestini, Alessio, Livi, Riccardo, Generini, Sergio, Gramigna, Leonardo, Benvenuti, Chiara, Carossino, Anna Maria, Conforti, Maria Letizia, Perfetto, Federico

“…:   Chronic sarcoidosis (CS) is often unresponsive to usual treatments. Melatonin, an immunoregulatory drug, was employed in CS patients in whom usual…”
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Therapeutic Challenges for Systemic Sclerosis by CERINIC MATUCCI, M., DEL ROSSO, ANGELA, FEDERICO, PERFETTO, LIVI, RICCARDO, FIORI, GINEVRA, BARTOLI, FRANCESCA, BLAGOJEVIC, JELENA, TEMPESTINI, ALESSIO, PIGNONE, ALBERTO

“…:  Pulmonary arterial hypertension (PAH) is an important cause of death in systemic sclerosis (SSc), despite the improvement of therapies. An early diagnosis…”
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Severe recurrent intrahepatic cholestasis in systemic AL amyloidosis without obvious liver involvement: unexplained hepatic toxicity or a case of misdiagnosed liver amyloidosis? by Paudice, Nunzia, Farsetti, Silvia, Caroti, Leonardo, Bandini, Sandro, Ciuti, Gabriele, Tempestini, Alessio, Perfetto, Federico, Galli, Simone, Giabbani, Letizia, Caldini, Anna Lucia, Bergesio, Franco

“…We report the case of a 50-year-old woman who was admitted to the hospital for acute abdominal pain with nephrotic proteinuria, rapidly progressive renal…”
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Apoptosis shifts to necrosis via intermediate types of cell death by a mechanism depending on c-myc and bcl-2 expression by Papucci, Laura, Formigli, Lucia, Schiavone, Nicola, Tani, Alessia, Donnini, Martino, Lapucci, Andrea, Perna, Federico, Tempestini, Alessio, Witort, Ewa, Morganti, Maria, Nosi, Daniele, Orlandini, Giovanni E, Zecchi Orlandini, Sandra, Capaccioli, Sergio

“…Hypoxic and chemical hypoxia (antimycin A) commits cultured rat fibroblasts (Rat-1) towards apoptosis, necrosis or an intermediate form of cell death…”
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Circadian phase difference of leptin in android versus gynoid obesity by Perfetto, Federico, Tarquini, Roberto, Cornélissen, Germaine, Mello, Giorgio, Tempestini, Alessio, Gaudiano, Paola, Mancuso, Francesco, Halberg, Franz

“…A circadian rhythm in serum leptin, measured every 4 h for 24 h, characterizes normal-weight women ( N = 14), and women with gynoid ( N = 17) or android ( N =…”
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Apoptosis Is Associated with Modifications of bcl-2 mRNA AU-Binding Proteins by Donnini, Martino, Lapucci, Andrea, Papucci, Laura, Witort, Ewa, Tempestini, Alessio, Brewer, Gary, Bevilacqua, Anna, Nicolin, Angelo, Capaccioli, Sergio, Schiavone, Nicola

“…The expression of genes requiring finely tuned control is regulated by a posttranscriptional mechanism involving mRNA A + U-rich elements (AREs) cooperating…”
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Molecular characterization of established human colon carcinoma cell lines (HCT-8) made resistant to 5-fluorouracil by different selection schedules by Tempestini, Alessio, Caciagli, Barbara, Morganti, Maria, Witort, Ewa, Nobili, Stefania, Papucci, Laura, Schiavone, Nicola, Donnini, Martino, Landini, Ida, Lapucci, Andrea, Perna, Federico, Lulli, Matteo, Mazzei, Teresita, Sobrero, Alberto, Mini, Enrico, Capaccioli, Sergio

“…To provide some insight into molecular mechanisms of 5 fluorouracil (5-FU) clinical resistance in colorectal cancer, we hypothesized that different in vitro…”
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Phosphodiester oligonucleotides inhibit mitosis and trigger apoptosis by a non-antisense, p53-mediated mechanism by Papucci, Laura, Schiavone, Nicola, Donnini, Martino, Lapucci, Andrea, Luzi, Ettore, Tempestini, Alessio, Witort, Ewa, Capaccioli, Sergio

“…Oligodeoxyribonucleotides (ODNs) are currently employed to switch-off genes selectively routinely in the laboratory practice. The drawback of ODN application…”
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