Search Results - "TELENTI, Amalio"

The Evolution and Biology of SARS-CoV-2 Variants by Telenti, Amalio, Hodcroft, Emma B, Robertson, David L

“…Our understanding of the still unfolding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic would have been extremely limited without the…”
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After the pandemic: perspectives on the future trajectory of COVID-19 by Telenti, Amalio, Arvin, Ann, Corey, Lawrence, Corti, Davide, Diamond, Michael S., García-Sastre, Adolfo, Garry, Robert F., Holmes, Edward C., Pang, Phillip S., Virgin, Herbert W.

“…There is a realistic expectation that the global effort in vaccination will bring the pandemic caused by severe acute respiratory syndrome coronavirus 2…”
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Regulatory genome variants in human susceptibility to infection by Telenti, Amalio, di Iulio, Julia

“…Genome studies have accelerated the discovery of common and rare genetic variants associated with susceptibility to infection and with disease severity…”
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Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody by Pinto, Dora, Park, Young-Jun, Beltramello, Martina, Walls, Alexandra C., Tortorici, M. Alejandra, Bianchi, Siro, Jaconi, Stefano, Culap, Katja, Zatta, Fabrizia, De Marco, Anna, Peter, Alessia, Guarino, Barbara, Spreafico, Roberto, Cameroni, Elisabetta, Case, James Brett, Chen, Rita E., Havenar-Daughton, Colin, Snell, Gyorgy, Telenti, Amalio, Virgin, Herbert W., Lanzavecchia, Antonio, Diamond, Michael S., Fink, Katja, Veesler, David, Corti, Davide

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged coronavirus that is responsible for the current pandemic of coronavirus disease…”
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Ranking of non-coding pathogenic variants and putative essential regions of the human genome by Wells, Alex, Heckerman, David, Torkamani, Ali, Yin, Li, Sebat, Jonathan, Ren, Bing, Telenti, Amalio, di Iulio, Julia

“…A gene is considered essential if loss of function results in loss of viability, fitness or in disease. This concept is well established for coding genes;…”
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N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 by McCallum, Matthew, De Marco, Anna, Lempp, Florian A., Tortorici, M. Alejandra, Pinto, Dora, Walls, Alexandra C., Beltramello, Martina, Chen, Alex, Liu, Zhuoming, Zatta, Fabrizia, Zepeda, Samantha, di Iulio, Julia, Bowen, John E., Montiel-Ruiz, Martin, Zhou, Jiayi, Rosen, Laura E., Bianchi, Siro, Guarino, Barbara, Fregni, Chiara Silacci, Abdelnabi, Rana, Foo, Shi-Yan Caroline, Rothlauf, Paul W., Bloyet, Louis-Marie, Benigni, Fabio, Cameroni, Elisabetta, Neyts, Johan, Riva, Agostino, Snell, Gyorgy, Telenti, Amalio, Whelan, Sean P.J., Virgin, Herbert W., Corti, Davide, Pizzuto, Matteo Samuele, Veesler, David

“…The SARS-CoV-2 spike (S) glycoprotein contains an immunodominant receptor-binding domain (RBD) targeted by most neutralizing antibodies (Abs) in COVID-19…”
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The fecal metabolome as a functional readout of the gut microbiome by Zierer, Jonas, Jackson, Matthew A., Kastenmüller, Gabi, Mangino, Massimo, Long, Tao, Telenti, Amalio, Mohney, Robert P., Small, Kerrin S., Bell, Jordana T., Steves, Claire J., Valdes, Ana M., Spector, Tim D., Menni, Cristina

“…The human gut microbiome plays a key role in human health 1 , but 16S characterization lacks quantitative functional annotation 2 . The fecal metabolome…”
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SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern by McCallum, Matthew, Bassi, Jessica, De Marco, Anna, Chen, Alex, Walls, Alexandra C, Di Iulio, Julia, Tortorici, M Alejandra, Navarro, Mary-Jane, Silacci-Fregni, Chiara, Saliba, Christian, Sprouse, Kaitlin R, Agostini, Maria, Pinto, Dora, Culap, Katja, Bianchi, Siro, Jaconi, Stefano, Cameroni, Elisabetta, Bowen, John E, Tilles, Sasha W, Pizzuto, Matteo Samuele, Guastalla, Sonja Bernasconi, Bona, Giovanni, Pellanda, Alessandra Franzetti, Garzoni, Christian, Van Voorhis, Wesley C, Rosen, Laura E, Snell, Gyorgy, Telenti, Amalio, Virgin, Herbert W, Piccoli, Luca, Corti, Davide, Veesler, David

“…A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally detected in California, carries spike glycoprotein mutations S13I in the…”
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Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies by Lempp, Florian A., Soriaga, Leah B., Montiel-Ruiz, Martin, Benigni, Fabio, Noack, Julia, Park, Young-Jun, Bianchi, Siro, Walls, Alexandra C., Bowen, John E., Zhou, Jiayi, Kaiser, Hannah, Joshi, Anshu, Agostini, Maria, Meury, Marcel, Dellota, Exequiel, Jaconi, Stefano, Cameroni, Elisabetta, Martinez-Picado, Javier, Vergara-Alert, Júlia, Izquierdo-Useros, Nuria, Virgin, Herbert W., Lanzavecchia, Antonio, Veesler, David, Purcell, Lisa A., Telenti, Amalio, Corti, Davide

“…SARS-CoV-2 infection—which involves both cell attachment and membrane fusion—relies on the angiotensin-converting enzyme 2 (ACE2) receptor, which is…”
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The blood DNA virome in 8,000 humans by Moustafa, Ahmed, Xie, Chao, Kirkness, Ewen, Biggs, William, Wong, Emily, Turpaz, Yaron, Bloom, Kenneth, Delwart, Eric, Nelson, Karen E, Venter, J Craig, Telenti, Amalio

“…The characterization of the blood virome is important for the safety of blood-derived transfusion products, and for the identification of emerging pathogens…”
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Sincell: an R/Bioconductor package for statistical assessment of cell-state hierarchies from single-cell RNA-seq by Juliá, Miguel, Telenti, Amalio, Rausell, Antonio

“…Cell differentiation processes are achieved through a continuum of hierarchical intermediate cell states that might be captured by single-cell RNA seq…”
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Comparison of phasing strategies for whole human genomes by Choi, Yongwook, Chan, Agnes P, Kirkness, Ewen, Telenti, Amalio, Schork, Nicholas J

“…Humans are a diploid species that inherit one set of chromosomes paternally and one homologous set of chromosomes maternally. Unfortunately, most human…”
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The Human Microbiome and Cancer by Rajagopala, Seesandra V, Vashee, Sanjay, Oldfield, Lauren M, Suzuki, Yo, Venter, J Craig, Telenti, Amalio, Nelson, Karen E

“…Recent scientific advances have significantly contributed to our understanding of the complex connection between the microbiome and cancer. Our bodies are…”
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Identification of Misclassified ClinVar Variants via Disease Population Prevalence by Shah, Naisha, Hou, Ying-Chen Claire, Yu, Hung-Chun, Sainger, Rachana, Caskey, C. Thomas, Venter, J. Craig, Telenti, Amalio

“…There is a significant interest in the standardized classification of human genetic variants. We used whole-genome sequence data from 10,495 unrelated…”
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Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity by Krapp, Christian, Hotter, Dominik, Gawanbacht, Ali, McLaren, Paul J., Kluge, Silvia F., Stürzel, Christina M., Mack, Katharina, Reith, Elisabeth, Engelhart, Susanne, Ciuffi, Angela, Hornung, Veit, Sauter, Daniel, Telenti, Amalio, Kirchhoff, Frank

“…Guanylate binding proteins (GBPs) are an interferon (IFN)-inducible subfamily of guanosine triphosphatases (GTPases) with well-established activity against…”
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Transcription Factor-Directed Re-wiring of Chromatin Architecture for Somatic Cell Nuclear Reprogramming toward trans-Differentiation by Dall’Agnese, Alessandra, Caputo, Luca, Nicoletti, Chiara, di Iulio, Julia, Schmitt, Anthony, Gatto, Sole, Diao, Yarui, Ye, Zhen, Forcato, Mattia, Perera, Ranjan, Bicciato, Silvio, Telenti, Amalio, Ren, Bing, Puri, Pier Lorenzo

“…MYOD-directed fibroblast trans-differentiation into skeletal muscle provides a unique model to investigate how one transcription factor (TF) reconfigures the…”
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Deep sequencing of 10,000 human genomes by Telenti, Amalio, Pierce, Levi C. T., Biggs, William H., di Iulio, Julia, Wong, Emily H. M., Fabani, Martin M., Kirkness, Ewen F., Moustafa, Ahmed, Shah, Naisha, Xie, Chao, Brewerton, Suzanne C., Bulsara, Nadeem, Garner, Chad, Metzker, Gary, Sandoval, Efren, Perkins, Brad A., Och, Franz J., Turpaz, Yaron, Venter, J. Craig

“…We report on the sequencing of 10,545 human genomes at 30×–40× coverage with an emphasis on quality metrics and novel variant and sequence discovery. We find…”
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Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses by Paust, Silke, Gill, Harvinder S, Wang, Bao-Zhong, Flynn, Michael P, Moseman, E Ashley, Senman, Balimkiz, Szczepanik, Marian, Telenti, Amalio, Askenase, Philip W, Compans, Richard W, von Andrian, Ulrich H

“…NK cells confer innate immune functions. Von Andrian and colleagues show that hepatic NK cells bearing CXCR6 receptors confer antigen-specific NK cell memory…”
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Single-cell analysis identifies cellular markers of the HIV permissive cell by Rato, Sylvie, Rausell, Antonio, Muñoz, Miguel, Telenti, Amalio, Ciuffi, Angela

“…Cellular permissiveness to HIV infection is highly heterogeneous across individuals. Heterogeneity is also found across CD4+ T cells from the same individual,…”
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HIV entry inhibitors by Esté, José A, Dr, Telenti, Amalio, MD

“…Summary The need for new classes of antiretroviral drugs has become apparent because of increasing concern about the long-term toxic effects of existing drugs,…”
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