Search Results - "TEIXIDO, Joaquin"

Resistance to MAPK Inhibitors in Melanoma Involves Activation of the IGF1R-MEK5-Erk5 Pathway by Benito-Jardón, Lucía, Díaz-Martínez, Marta, Arellano-Sánchez, Nohemi, Vaquero-Morales, Paloma, Esparís-Ogando, Azucena, Teixidó, Joaquin

“…Combined treatment of metastatic melanoma with BRAF and MEK inhibitors has improved survival, but the emergence of resistance represents an important clinical…”
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RGS10 restricts upregulation by chemokines of T cell adhesion mediated by α4β1 and αLβ2 integrins by García-Bernal, David, Dios-Esponera, Ana, Sotillo-Mallo, Elena, García-Verdugo, Rosa, Arellano-Sánchez, Nohemí, Teixidó, Joaquin

“…Chemokines rapidly and transiently upregulate α4β1 and αLβ2 integrin-mediated adhesion during T lymphocyte extravasation by activating Gα-dependent inside-out…”
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Chemokine-Induced Zap70 Kinase-Mediated Dissociation of the Vav1-Talin Complex Activates α4β1 Integrin for T Cell Adhesion by García-Bernal, David, Parmo-Cabañas, Marisa, Dios-Esponera, Ana, Samaniego, Rafael, de la Ossa, Dolores Hernán-P, Teixidó, Joaquin

“…Lymphocyte integrins mediate cell arrest on endothelium during immune surveillance after activation by chemokine-stimulated inside-out signals. Here we show…”
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miR-204-5p and miR-211-5p Contribute to BRAF Inhibitor Resistance in Melanoma by Díaz-Martínez, Marta, Benito-Jardón, Lucía, Alonso, Lola, Koetz-Ploch, Lisa, Hernando, Eva, Teixidó, Joaquin

“…Melanoma treatment with the BRAF V600E inhibitor vemurafenib provides therapeutic benefits but the common emergence of drug resistance remains a challenge. We…”
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The good and bad faces of the CXCR4 chemokine receptor by Teixidó, Joaquin, Martínez-Moreno, Mónica, Díaz-Martínez, Marta, Sevilla-Movilla, Silvia

“…Chemokines are chemotactic cytokines that promote cell migration and activation under homeostatic and inflammatory conditions. Chemokines bind to seven…”
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Molecular Players in Hematologic Tumor Cell Trafficking by Redondo-Muñoz, Javier, García-Pardo, Angeles, Teixidó, Joaquin

“…The trafficking of neoplastic cells represents a key process that contributes to progression of hematologic malignancies. Diapedesis of neoplastic cells across…”
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Editorial: Leukocyte Trafficking in Homeostasis and Disease by Teixidó, Joaquin, Hidalgo, Andres, Fagerholm, Susanna

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Upregulated expression and function of the α4β1 integrin in multiple myeloma cells resistant to bortezomib by Sevilla‐Movilla, Silvia, Arellano‐Sánchez, Nohemí, Martínez‐Moreno, Mónica, Gajate, Consuelo, Sánchez‐Vencells, Anna, Valcárcel, Luis V, Agirre, Xabier, Valeri, Antonio, Martínez‐López, Joaquin, Prósper, Felipe, Mollinedo, Faustino, Teixidó, Joaquin

“…The interaction of multiple myeloma (MM) cells with the bone marrow (BM) microenvironment promotes MM cell retention, survival, and resistance to different…”
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Maturation-Dependent Expression and Function of the CD49d Integrin on Monocyte-Derived Human Dendritic Cells by Puig-Kroger, Amaya, Sanz-Rodriguez, Francisco, Longo, Natividad, Sanchez-Mateos, Paloma, Botella, Luisa, Teixido, Joaquin, Bernabeu, Carmelo, Corbi, Angel L

“…Dendritic cells (DC) are highly specialized APC that are critical for the initiation of T cell-dependent immune responses. DC exert a sentinel function while…”
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Sphingosine-1-phosphate activates chemokine-promoted myeloma cell adhesion and migration involving α4β1 integrin function by García-Bernal, David, Redondo-Muñoz, Javier, Dios-Esponera, Ana, Chèvre, Raphaël, Bailón, Elvira, Garayoa, Mercedes, Arellano-Sánchez, Nohemí, Gutierrez, Norma C, Hidalgo, Andrés, García-Pardo, Angeles, Teixidó, Joaquin

“…Myeloma cell adhesion dependent on α4β1 integrin is crucial for the progression of multiple myeloma (MM). The α4β1‐dependent myeloma cell adhesion is…”
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The MRL proteins: Adapting cell adhesion, migration and growth by Coló, Georgina P., Lafuente, Esther M., Teixidó, Joaquin

“…MIG-10, RIAM and Lamellipodin (Lpd) are the founding members of the MRL family of multi-adaptor molecules. These proteins have common domain structures but…”
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Chemokine stromal cell-derived factor-1α modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1 by Sanz-Rodrı́guez, Francisco, Hidalgo, Andrés, Teixidó, Joaquin

“…The chemokine stromal cell-derived factor-1α (SDF-1α) and its G-protein–linked receptor CXCR4 are involved in hematopoietic progenitor cell and lymphocyte…”
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Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion by BARTOLOME, Rubén A, MOLINA-ORTIZ, Isabel, SAMANIEGO, Rafael, SANCHEZ-MATEOS, Paloma, BUSTELO, Xose R, TEIXIDO, Joaquin

“…Melanoma cells express the chemokine receptor CXCR4, which confers invasive signals on binding to its ligand CXCL12. We show here that knocking down…”
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Regulation of miRNA expression by α4β1 integrin‐dependent multiple myeloma cell adhesion by Rodríguez‐García, Yaiza, Martínez‐Moreno, Mónica, Alonso, Lola, Sánchez‐Vencells, Anna, Arranz, Alicia, Dagà‐Millán, Roger, Sevilla‐Movilla, Silvia, Valeri, Antonio, Martínez‐López, Joaquin, Teixidó, Joaquin

“…The α4β1 integrin regulates the trafficking of multiple myeloma (MM) cells and contributes to MM disease progression. MicroRNAs (miRNAs) can have both tumor…”
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Focal adhesion disassembly is regulated by a RIAM to MEK-1 pathway by Coló, Georgina P, Hernández-Varas, Pablo, Lock, John, Bartolomé, Rubén A, Arellano-Sánchez, Nohemí, Strömblad, Staffan, Teixidó, Joaquin

“…Cell migration and invasion require regulated turnover of integrin-dependent adhesion complexes. Rap1-GTP-interacting adaptor molecule (RIAM) is an adaptor…”
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Overexpression of E-cadherin on Melanoma Cells Inhibits Chemokine-promoted Invasion Involving p190RhoGAP/p120ctn-dependent Inactivation of RhoA by Molina-Ortiz, Isabel, Bartolomé, Rubén A., Hernández-Varas, Pablo, Colo, Georgina P., Teixidó, Joaquin

“…Melanoma cells express the chemokine receptor CXCR4 that confers high invasiveness upon binding to its ligand CXCL12. Melanoma cells at initial stages of the…”
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The Chemokine Receptor CXCR4 and the Metalloproteinase MT1-MMP Are Mutually Required during Melanoma Metastasis to Lungs by Bartolomé, Rubén A, Ferreiro, Sergio, Miquilena-Colina, María E, Martínez-Prats, Lorena, Soto-Montenegro, María L, García-Bernal, David, Vaquero, Juan J, Agami, Reuven, Delgado, Rafael, Desco, Manuel, Sánchez-Mateos, Paloma, Teixidó, Joaquin

“…Melanoma is the most aggressive skin cancer once metastasis begins; therefore, it is important to characterize the molecular players involved in melanoma…”
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Stromal cell-derived factor-1α promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities by BARTOLOME, Rubén A, GALVEZ, Beatriz G, LONGO, Natividad, BALEUX, Francoise, VAN MUIJEN, Goos N. P, SANCHEZ-MATEOS, Paloma, ARROYO, Alicia G, TEIXIDO, Joaquin

“…Tissue invasion by tumor cells involves their migration across basement membranes through activation of extracellular matrix degradation and cell motility…”
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Transforming growth factor-β1 down-regulates expression of chemokine stromal cell–derived factor-1: functional consequences in cell migration and adhesion by Wright, Natalia, de Lera, Teresa Laín, García-Moruja, Carelia, Lillo, Rosa, García-Sánchez, Félix, Caruz, Antonio, Teixidó, Joaquin

“…Chemokine stromal cell–derived factor-1 (SDF-1) is expressed by bone marrow (BM) stromal cells and plays key roles in BM cell migration. Modulation of its…”
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Rap1-GTP-interacting Adaptor Molecule (RIAM) Protein Controls Invasion and Growth of Melanoma Cells by Hernández-Varas, Pablo, Coló, Georgina P., Bartolomé, Ruben A., Paterson, Andrew, Medraño-Fernández, Iria, Arellano-Sánchez, Nohemí, Cabañas, Carlos, Sánchez-Mateos, Paloma, Lafuente, Esther M., Boussiotis, Vassiliki A., Strömblad, Staffan, Teixidó, Joaquin

“…The Mig-10/RIAM/lamellipodin (MRL) family member Rap1-GTP-interacting adaptor molecule (RIAM) interacts with active Rap1, a small GTPase that is frequently…”
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