Search Results - "TEESALU, Tambet"

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity by Cantuti-Castelvetri, Ludovico, Ojha, Ravi, Pedro, Liliana D, Djannatian, Minou, Franz, Jonas, Kuivanen, Suvi, van der Meer, Franziska, Kallio, Katri, Kaya, Tuğberk, Anastasina, Maria, Smura, Teemu, Levanov, Lev, Szirovicza, Leonora, Tobi, Allan, Kallio-Kokko, Hannimari, Österlund, Pamela, Joensuu, Merja, Meunier, Frédéric A, Butcher, Sarah J, Winkler, Martin Sebastian, Mollenhauer, Brit, Helenius, Ari, Gokce, Ozgun, Teesalu, Tambet, Hepojoki, Jussi, Vapalahti, Olli, Stadelmann, Christine, Balistreri, Giuseppe, Simons, Mikael

“…The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For many viruses, tissue…”
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Neuropilin-1 is a host factor for SARS-CoV-2 infection by Daly, James L, Simonetti, Boris, Klein, Katja, Chen, Kai-En, Williamson, Maia Kavanagh, Antón-Plágaro, Carlos, Shoemark, Deborah K, Simón-Gracia, Lorena, Bauer, Michael, Hollandi, Reka, Greber, Urs F, Horvath, Peter, Sessions, Richard B, Helenius, Ari, Hiscox, Julian A, Teesalu, Tambet, Matthews, David A, Davidson, Andrew D, Collins, Brett M, Cullen, Peter J, Yamauchi, Yohei

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), uses the viral spike (S) protein for…”
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C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration by Teesalu, Tambet, Sugahara, Kazuki N, Kotamraju, Venkata Ramana, Ruoslahti, Erkki

“…Screening of phage libraries expressing random peptides for binding to prostate cancer cells primarily yielded peptides that had a C-terminal arginine (or…”
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Antibiotic-loaded nanoparticles targeted to the site of infection enhance antibacterial efficacy by Hussain, Sazid, Joo, Jinmyoung, Kang, Jinyoung, Kim, Byungji, Braun, Gary B., She, Zhi-Gang, Kim, Dokyoung, Mann, Aman P., Mölder, Tarmo, Teesalu, Tambet, Carnazza, Santina, Guglielmino, Salvatore, Sailor, Michael J., Ruoslahti, Erkki

“…Bacterial resistance to antibiotics has made it necessary to resort to using antibacterial drugs that have considerable toxicities. Here, we show that…”
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P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas by Rousso-Noori, Liat, Mastandrea, Ignacio, Talmor, Shauli, Waks, Tova, Globerson Levin, Anat, Haugas, Maarja, Teesalu, Tambet, Alvarez-Vallina, Luis, Eshhar, Zelig, Friedmann-Morvinski, Dinorah

“…Glioblastoma is considered one of the most aggressive malignancies in adult and pediatric patients. Despite decades of research no curative treatment is…”
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Tumor-penetrating therapy for β5 integrin-rich pancreas cancer by Hurtado de Mendoza, Tatiana, Mose, Evangeline S., Botta, Gregory P., Braun, Gary B., Kotamraju, Venkata R., French, Randall P., Suzuki, Kodai, Miyamura, Norio, Teesalu, Tambet, Ruoslahti, Erkki, Lowy, Andrew M., Sugahara, Kazuki N.

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked desmoplasia and drug resistance due, in part, to poor drug delivery to extravascular tumor…”
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Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs by Sugahara, Kazuki N., Teesalu, Tambet, Karmali, Priya Prakash, Kotamraju, Venkata Ramana, Agemy, Lilach, Greenwald, Daniel R., Ruoslahti, Erkki

“…Poor penetration of anticancer drugs into tumors can be an important factor limiting their effícacy. We studied mouse tumor models to show that a previously…”
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An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability by Pang, Hong-Bo, Braun, Gary B., Friman, Tomas, Aza-Blanc, Pedro, Ruidiaz, Manuel E., Sugahara, Kazuki N., Teesalu, Tambet, Ruoslahti, Erkki

“…Neuropilins (NRPs) are trans-membrane receptors involved in axon guidance and vascular development. Many growth factors and other signalling molecules bind to…”
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Peritoneal Carcinomatosis Targeting with Tumor Homing Peptides by Simón-Gracia, Lorena, Hunt, Hedi, Teesalu, Tambet

“…Over recent decades multiple therapeutic approaches have been explored for improved management of peritoneally disseminated malignancies-a grim condition known…”
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A high-throughput label-free nanoparticle analyser by Fraikin, Jean-Luc, Teesalu, Tambet, McKenney, Christopher M., Ruoslahti, Erkki, Cleland, Andrew N.

“…Synthetic nanoparticles and genetically modified viruses are used in a range of applications, but high-throughput analytical tools for the physical…”
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Editorial on Special Issue "Precision Delivery of Drugs and Imaging Agents with Peptides" by Kurrikoff, Kaido, Teesalu, Tambet

“…Homing peptides and cell-penetrating peptides allow for systemic targeting of diseased tissues and/or efficient intracellular delivery of payloads [...]…”
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A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries by Mann, Aman P., Scodeller, Pablo, Hussain, Sazid, Joo, Jinmyoung, Kwon, Ester, Braun, Gary B., Mölder, Tarmo, She, Zhi-Gang, Kotamraju, Venkata Ramana, Ranscht, Barbara, Krajewski, Stan, Teesalu, Tambet, Bhatia, Sangeeta, Sailor, Michael J., Ruoslahti, Erkki

“…Traumatic brain injury (TBI) is a major health and socio-economic problem, but no pharmacological agent is currently approved for the treatment of acute TBI…”
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Tumor-penetrating peptide for systemic targeting of Tenascin-C by Lingasamy, Prakash, Tobi, Allan, Kurm, Kaarel, Kopanchuk, Sergei, Sudakov, Aleksander, Salumäe, Markko, Rätsep, Tõnu, Asser, Toomas, Bjerkvig, Rolf, Teesalu, Tambet

“…Extracellular matrix in solid tumors has emerged as a specific, stable, and abundant target for affinity-guided delivery of anticancer drugs. Here we describe…”
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Cationic Liposomes as Vectors for Nucleic Acid and Hydrophobic Drug Therapeutics by Ewert, Kai K, Scodeller, Pablo, Simón-Gracia, Lorena, Steffes, Victoria M, Wonder, Emily A, Teesalu, Tambet, Safinya, Cyrus R

“…Cationic liposomes (CLs) are effective carriers of a variety of therapeutics. Their applications as vectors of nucleic acids (NAs), from long DNA and mRNA to…”
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Mapping of vascular ZIP codes by phage display by Teesalu, Tambet, Sugahara, Kazuki N, Ruoslahti, Erkki

“…Each organ and pathology has a unique vascular ZIP code that can be targeted with affinity ligands. In vivo peptide phage display can be used for unbiased…”
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Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease by Mann, Aman P., Scodeller, Pablo, Hussain, Sazid, Braun, Gary B., Mölder, Tarmo, Toome, Kadri, Ambasudhan, Rajesh, Teesalu, Tambet, Lipton, Stuart A., Ruoslahti, Erkki

“…Cerebrovascular changes occur in Alzheimer’s disease (AD). Using in vivo phage display, we searched for molecular markers of the neurovascular unit, including…”
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Tumor-penetrating iRGD peptide inhibits metastasis by Sugahara, Kazuki N, Braun, Gary B, de Mendoza, Tatiana Hurtado, Kotamraju, Venkata Ramana, French, Randall P, Lowy, Andrew M, Teesalu, Tambet, Ruoslahti, Erkki

“…Tumor-specific tissue-penetrating peptides deliver drugs into extravascular tumor tissue by increasing tumor vascular permeability through interaction with…”
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ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1 by Simonetti, Boris, Daly, James L, Simón-Gracia, Lorena, Klein, Katja, Weeratunga, Saroja, Antón-Plágaro, Carlos, Tobi, Allan, Hodgson, Lorna, Lewis, Philip A, Heesom, Kate J, Shoemark, Deborah K, Davidson, Andrew D, Collins, Brett M, Teesalu, Tambet, Yamauchi, Yohei, Cullen, Peter J

“…Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal…”
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Targeting vascular disrupting agent-treated tumor microenvironment with tissue-penetrating nanotherapy by Sidorenko, Valeria, Scodeller, Pablo, Uustare, Ain, Ogibalov, Ivan, Tasa, Andrus, Tshubrik, Olga, Salumäe, Liis, Sugahara, Kazuki N., Simón-Gracia, Lorena, Teesalu, Tambet

“…Cancer treatment with vascular disrupting agents (VDAs) causes rapid and extensive necrosis in solid tumors. However, these agents fall short in eliminating…”
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The Production of Plasma Activated Water in Controlled Ambient Gases and its Impact on Cancer Cell Viability by Raud, Sirli, Raud, Jüri, Jõgi, Indrek, Piller, Carl-Thomas, Plank, Toomas, Talviste, Rasmus, Teesalu, Tambet, Vasar, Eero

“…The present study investigated the effect of plasma-produced reactive oxygen (ROS) and nitrogen (RNS) species on cancer cell viability. Reactive species were…”
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