Search Results - "TEEBOR, GEORGE W"

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA by Chan, Michael K., Ocampo-Hafalla, Maria T., Vartanian, Vladimir, Jaruga, Pawel, Kirkali, Güldal, Koenig, Karen L., Brown, Stuart, Lloyd, R. Stephen, Dizdaroglu, Miral, Teebor, George W.

“…We have generated a strain of mice lacking two DNA N-glycosylases of base excision repair (BER), NTH1 and NEIL1, homologs of bacterial Nth (endonuclease three)…”
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The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells by Ucher, Anna J, Linehan, Erin K, Teebor, George W, Schrader, Carol E, Stavnezer, Janet

“…During activation of B cells to undergo class switching, B cell metabolism is increased, and levels of reactive oxygen species (ROS) are increased. ROS can…”
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Targeted Deletion of mNth1 Reveals a Novel DNA Repair Enzyme Activity by Ocampo, Maria T. A., Chaung, Wenren, Marenstein, Dina R., Chan, Michael K., Altamirano, Alvin, Basu, Ashis K., Boorstein, Robert J., Cunningham, Richard P., Teebor, George W.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Repair of thymine glycol by hNth1 and hNeil1 is modulated by base pairing and cis–trans epimerization by Ocampo-Hafalla, Maria T., Altamirano, Alvin, Basu, Ashis K., Chan, Michael K., Ocampo, Jose Eliseo A., Cummings, Archie, Boorstein, Robert J., Cunningham, Richard P., Teebor, George W.

“…Oxidation of thymine yields 5,6-dihydroxy-5,6-dihydrothymine (thymine glycol. Tg) which, as cis 5S,6R and 5R,6S 2’-deoxyribonucleoside diastereoisomers (dTg1,…”
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DNA Polymerase λ Protects Mouse Fibroblasts against Oxidative DNA Damage and Is Recruited to Sites of DNA Damage/Repair by Braithwaite, Elena K., Kedar, Padmini S., Lan, Li, Polosina, Yaroslava Y., Asagoshi, Kenjiro, Poltoratsky, Vladimir P., Horton, Julie K., Miller, Holly, Teebor, George W., Yasui, Akira, Wilson, Samuel H.

“…DNA polymerase λ (pol λ) is a member of the X family of DNA polymerases that has been implicated in both base excision repair and non-homologous end joining…”
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Purification of a Mammalian Homologue of Escherichia coli Endonuclease III:  Identification of a Bovine Pyrimidine Hydrate-Thymine Glycol DNA-Glycosylase/AP Lyase by Irreversible Cross Linking to a Thymine Glycol-Containing Oligodeoxynucleotide by Hilbert, Timothy P, Boorstein, Robert J, Kung, Hsiang Chuan, Bolton, Philip H, Xing, Dongxia, Cunningham, Richard P, Teebor, George W

“…We purified a homologue of the Escherichia coli DNA repair enzyme endonuclease III 5000-fold from calf thymus which, like endonuclease III, demonstrates…”
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Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity by Marenstein, Dina R, Chan, Michael K, Altamirano, Alvin, Basu, Ashis K, Boorstein, Robert J, Cunningham, Richard P, Teebor, George W

“…Base excision repair of oxidized pyrimidines in human DNA is initiated by the DNA N-glycosylase/apurinic/apyrimidinic (AP) lyase, human NTH1 (hNTH1), the…”
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Definitive Identification of Mammalian 5-Hydroxymethyluracil DNA N-Glycosylase Activity as SMUG1 by Boorstein, Robert J., Archie, Cummings, Marenstein, Dina R., Chan, Michael K., Ma, Yuliang, Neubert, Thomas A., Brown, Stuart M., Teebor, George W.

“…Purification from calf thymus of a DNA N-glycosylase activity (HMUDG) that released 5-hydroxymethyluracil (5hmUra) from the DNA of Bacillus subtilis phage SPO1…”
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Cloning and Expression of the cDNA Encoding the Human Homologue of the DNA Repair Enzyme, Escherichia coli Endonuclease III by Hilbert, Timothy P., Chaung, Wenren, Boorstein, Robert J., Cunningham, Richard P., Teebor, George W.

“…We previously purified a bovine pyrimidine hydrate-thymine glycol DNA glycosylase/AP lyase. The amino acid sequence of tryptic bovine peptides was homologous…”
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Quantitative determination of the 5-(hydroxymethyl)uracil moiety in the DNA of .gamma.-irradiated cells by Frenkel, Krystyna, Cummings, Archie, Solomon, Jerome, Cadet, Jean, Steinberg, Jacob J, Teebor, George W

“…5-(Hydroxymethyl)uracil (HMUra) is a chemically stable derivative of thymine formed through the action of ionizing radiation which we previously identified in…”
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Expression of the human DNA glycosylase hSMUG1 in Trypanosoma brucei causes DNA damage and interferes with J biosynthesis by Ulbert, Sebastian, Cross, Mike, Boorstein, Robert J., Teebor, George W., Borst, Piet

“…In kinetoplastid flagellates such as Trypanosoma brucei, a small percentage of the thymine residues in the nuclear DNA is replaced by the modified base…”
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Human AP endonuclease (APE1) demonstrates endonucleolytic activity against AP sites in single-stranded DNA by Marenstein, Dina R., Wilson, David M., Teebor, George W.

“…Human apurinic/apyrimidinic endonuclease (APE1) is an enzyme of DNA base excision repair (BER) which catalyzes endonucleolytic cleavage immediately 5′ to…”
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Substrate Specificity of Human Endonuclease III (hNTH1) by Marenstein, Dina R., Chan, Michael K., Altamirano, Alvin, Basu, Ashis K., Boorstein, Robert J., Cunningham, Richard P., Teebor, George W.

“…Base excision repair of oxidized pyrimidines in human DNA is initiated by the DNA N -glycosylase/apurinic/apyrimidinic (AP) lyase, human NTH1 (hNTH1), the…”
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Identification of the cis-thymine glycol moiety in oxidized deoxyribonucleic acid by Frenkel, Krystyna, Goldstein, Mindy S, Duker, Nahum J, Teebor, George W

“…5,6-Dihydroxy-5,6-dihydrothymine (thymine glycol) is formed in DNA by reaction with oxidizing agents and as a result of ionizing and near-ultraviolet…”
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Excessive base excision repair of 5-hydroxymethyluracil from DNA induces apoptosis in Chinese hamster V79 cells containing mutant p53 by Mi, Li-Jun, Chaung, Wenren, Horowitz, Robert, Teebor, George W., Boorstein, Robert J.

“…We have demonstrated previously that the toxicity of 5-hydroxymethyl-2′-deoxyuridine (hmdUrd) to Chinese hamster fibroblasts (V79 cells) results from enzymatic…”
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The repairability of oxidative free radical mediated damage to DNA: a review by Teebor, G W, Boorstein, R J, Cadet, J

“…Many DNA repair enzyme activities are present in both prokaryotic and eukaryotic organisms. Among these are DNA exo- and endonucleases and DNA glycosylases…”
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Identification of the cis-thymine glycol moiety in chemically oxidized and .gamma.-irradiated DNA by HPLC analysis by Frenkel, Krystyna, Goldstein, Mindy S, Teebor, George W

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Formation and stability of repairable pyrimidine photohydrates in DNA by Boorstein, Robert J, Hilbert, Timothy P, Cunningham, Richard P, Teebor, George W

“…Ultraviolet irradiation of poly(dG-dC) and poly(dA-dU) in solution produces pyrimidine hydrates that are repaired by bacterial and mammalian DNA glycosylases…”
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Effect of pH and Temperature on the Stability of UV-Induced Repairable Pyrimidine Hydrates in DNA by O'Donnell, Robert E, Boorstein, Robert J, Cunningham, Richard P, Teebor, George W

“…UV irradiation of cytosine yields 6-hydroxy-5,6-dihydrocytosine (cytosine hydrate) whether the cytosine is in solution as base, nucleoside, or nucleotide or on…”
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Comparison of the Effects of UV Irradiation on 5-Methyl-Substituted and Unsubstituted Pyrimidines in Alternating Pyrimidine-Purine Sequences in DNA by Zuo, Shaojun, Boorstein, Robert J, Cunningham, Richard P, Teebor, George W

“…We previously demonstrated the UV-induced formation of cytosine hydrate in DNA and its deamination product, uracil hydrate, via their release from the DNA…”
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