Search Results - "TAYLOR, Kenneth A"
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Structural Organization of the Actin Cytoskeleton at Sites of Clathrin-Mediated Endocytosis
Published in Current biology (26-07-2011)“…The dynamic actin cytoskeleton plays an important role in clathrin-mediated endocytosis (CME). However, its exact functions remain uncertain as a result of a…”
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2
Structure of the Drosophila melanogaster Flight Muscle Myosin Filament at 4.7 Å Resolution Reveals New Details of Non-Myosin Proteins
Published in International journal of molecular sciences (05-10-2023)“…Striated muscle thick filaments are composed of myosin II and several non-myosin proteins which define the filament length and modify its function. Myosin II…”
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3
Identifying characteristics and clinical conditions associated with hand grip strength in adults: the Project Baseline Health Study
Published in Scientific reports (18-04-2024)“…Low hand grip strength (HGS) is associated with several conditions, but its value outside of the older adult population is unclear. We sought to identify the…”
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4
The myosin II coiled-coil domain atomic structure in its native environment
Published in Proceedings of the National Academy of Sciences - PNAS (06-04-2021)“…The atomic structure of the complete myosin tail within thick filaments isolated from Lethocerus indicus flight muscle is described and compared to crystal…”
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5
Distribution and three-dimensional structure of AIDS virus envelope spikes
Published in Nature (15-06-2006)“…Envelope glycoprotein (Env) spikes on AIDS retroviruses initiate infection of host cells and are therefore targets for vaccine development. Though crystal…”
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6
Recreation of the terminal events in physiological integrin activation
Published in The Journal of cell biology (11-01-2010)“…Increased affinity of integrins for the extracellular matrix (activation) regulates cell adhesion and migration, extracellular matrix assembly, and…”
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7
Structure of the Flight Muscle Thick Filament from the Bumble Bee, Bombus ignitus , at 6 Å Resolution
Published in International journal of molecular sciences (26-12-2022)“…Four insect orders have flight muscles that are both asynchronous and indirect; they are asynchronous in that the wingbeat frequency is decoupled from the…”
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8
The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand
Published in The Journal of biological chemistry (06-11-2015)“…Increased ligand binding to integrin (“activation”) underpins many biological processes, such as leukocyte trafficking, cell migration, host-pathogen…”
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9
Structure of AAV-DJ, a Retargeted Gene Therapy Vector: Cryo-Electron Microscopy at 4.5 Å Resolution
Published in Structure (London) (08-08-2012)“…AAV-DJ, a leading candidate vector for liver gene therapy, was created through random homologous recombination followed by directed evolution, selecting for…”
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10
Insights into Actin-Myosin Interactions within Muscle from 3D Electron Microscopy
Published in International journal of molecular sciences (05-04-2019)“…Much has been learned about the interaction between myosin and actin through biochemistry, in vitro motility assays and cryo-electron microscopy (cryoEM) of…”
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Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography
Published in Nature (13-07-2006)“…Unconventional myosin V (myoV) is an actin-based molecular motor that has a key function in organelle and mRNA transport, as well as in membrane trafficking…”
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12
Coupling between myosin head conformation and the thick filament backbone structure
Published in Journal of structural biology (01-12-2017)“…The recent high-resolution structure of the thick filament from Lethocerus asynchronous flight muscle shows aspects of thick filament structure never before…”
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13
Adeno-associated virus-2 and its primary cellular receptor—Cryo-EM structure of a heparin complex
Published in Virology (New York, N.Y.) (15-03-2009)“…Abstract Adeno-associated virus serotype 2 (AAV-2) is a leading candidate vector for gene therapy. Cell entry starts with attachment to a primary receptor,…”
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14
Tomographic subvolume alignment and subvolume classification applied to myosin V and SIV envelope spikes
Published in Journal of structural biology (01-02-2009)“…Electron tomography is a technique for three-dimensional reconstruction, that is widely used for imaging macromolecules, macromolecular assemblies or whole…”
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15
Structural Comparison of HIV-1 Envelope Spikes with and without the V1/V2 Loop
Published in Journal of Virology (01-03-2011)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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16
Electron tomography of cryofixed, isometrically contracting insect flight muscle reveals novel actin-myosin interactions
Published in PloS one (09-09-2010)“…Isometric muscle contraction, where force is generated without muscle shortening, is a molecular traffic jam in which the number of actin-attached motors is…”
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17
Factors associated with lower quarter performance-based balance and strength tests: a cross-sectional analysis from the project baseline health study
Published in Frontiers in sports and active living (15-07-2024)“…Physical performance tests are predictive of mortality and may screen for certain health conditions (e.g., sarcopenia); however, their diagnostic and/or…”
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Electron Tomography Analysis of Envelope Glycoprotein Trimers on HIV and Simian Immunodeficiency Virus Virions
Published in Proceedings of the National Academy of Sciences - PNAS (23-12-2003)“…We used electron tomography to directly visualize trilobed presumptive envelope (env) glycoprotein structures on the surface of negatively stained HIV type I…”
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19
Cryoelectron tomography of HIV-1 envelope spikes: further evidence for tripod-like legs
Published in PLoS pathogens (01-11-2008)“…A detailed understanding of the morphology of the HIV-1 envelope (Env) spike is key to understanding viral pathogenesis and for informed vaccine design. We…”
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20
John Squire and the myosin thick filament structure in muscle
Published in Journal of muscle research and cell motility (01-09-2023)“…The structure of the thin, actin-containing filament of muscle is both highly conserved across a broad range of muscle types and is now well understood. The…”
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