Search Results - "TAYLOR, K. J"

Synthesis of Spirocyclic Indolenines by James, Michael J., O'Brien, Peter, Taylor, Richard J. K., Unsworth, William P.

“…This Review provides an in‐depth account of the synthesis of spirocyclic indolenines. Over the last 77 years, a wide array of diverse synthetic methods has…”
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Emergence of Palladium(IV) Chemistry in Synthesis and Catalysis by Sehnal, Petr, Taylor, Richard J. K, Fairlamb, Ian J. S

“…The use of palladium(IV) in chemical synthesis and catalysis is investigated. New chemical reactions have been made possible…”
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Silver(I)- or Copper(II)-Mediated Dearomatization of Aromatic Ynones: Direct Access to Spirocyclic Scaffolds by James, Michael J., Cuthbertson, James D., O'Brien, Peter, Taylor, Richard J. K., Unsworth, William P.

“…A high‐yielding silver(I)‐ or copper(II)‐catalyzed dearomatizing spirocyclization strategy allows the conversion of simple aromatic compounds that contain…”
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Catalyst-Driven Scaffold Diversity: Selective Synthesis of Spirocycles, Carbazoles and Quinolines from Indolyl Ynones by Liddon, John T. R., James, Michael J., Clarke, Aimee K., O'Brien, Peter, Taylor, Richard J. K., Unsworth, William P.

“…Medicinally relevant spirocyclic indolenines, carbazoles and quinolines can each be directly synthesised selectively from common indolyl ynone starting…”
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Photocatalytic Deoxygenation of Sulfoxides Using Visible Light: Mechanistic Investigations and Synthetic Applications by Clarke, Aimee K, Parkin, Alison, Taylor, Richard J. K, Unsworth, William P, Rossi-Ashton, James A

“…The photocatalytic deoxygenation of sulfoxides to generate sulfides facilitated by either Ir­[(dF­(CF3)­ppy)2(dtbbpy)]­PF6 or fac-Ir­(ppy)3 is reported…”
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Modular Synthesis of Polycyclic Alkaloid Scaffolds via an Enantioselective Dearomative Cascade by Rossi-Ashton, James A, Clarke, Aimee K, Taylor, Richard J. K, Unsworth, William P

“…The polycyclic core of the akuammiline alkaloids can be synthesized from simple tryptamine and tryptophol derivatives via a Ag­(I)-catalyzed enantioselective…”
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Preparation and Reactions of Indoleninyl Halides: Scaffolds for the Synthesis of Spirocyclic Indole Derivatives by Liddon, John T. R, Clarke, Aimee K, Taylor, Richard J. K, Unsworth, William P

“…The dearomatization of 2-haloindole precursors allows access to indoleninyl halides, a hitherto underexploited functional handle with broad synthetic utility…”
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Direct Imine Acylation: Rapid Access to Diverse Heterocyclic Scaffolds by Unsworth, William P, Kitsiou, Christiana, Taylor, Richard J. K

“…A simple and efficient procedure to prepare a range of diverse heterocycles by the direct acylation of imines using a variety of functionalized benzoic acids…”
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Dearomatizing Spiroannulation Reagents: Direct Access to Spirocycles from Indoles and Dihalides by Liddon, John T. R, Rossi-Ashton, James A, Taylor, Richard J. K, Unsworth, William P

“…Unfunctionalized indoles can be directly converted into 3,3′-spirocyclic indolenines and indolines upon reaction with electrophilic dihalides in the presence…”
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First C−H Activation Route to Oxindoles using Copper Catalysis by Klein, Johannes E. M. N, Perry, Alexis, Pugh, David S, Taylor, Richard J. K

“…The preparation of 3,3-disubstituted oxindoles by a formal C−H, Ar−H coupling of anilides is described. Highly efficient conditions have been identified using…”
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From Heteroaromatic Acids and Imines to Azaspirocycles: Stereoselective Synthesis and 3D Shape Analysis by Chambers, Sarah J., Coulthard, Graeme, Unsworth, William P., O'Brien, Peter, Taylor, Richard J. K.

“…Heteroaromatic carboxylic acids have been directly coupled with imines using propylphosphonic anhydride (T3P) and NEt(iPr)2 to form azaspirocycles via…”
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Copper-Mediated Construction of Spirocyclic Bis-oxindoles via a Double C–H, Ar–H Coupling Process by Drouhin, Pauline, Hurst, Timothy E, Whitwood, Adrian C, Taylor, Richard J. K

“…A double C–H, Ar–H coupling process for the conversion of bis-anilides into spirocyclic bis-oxindoles, enabling the concomitant formation of two all-carbon…”
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3-Alkenyl-oxindoles: Natural Products, Pharmaceuticals, and Recent Synthetic Advances in Tandem/Telescoped Approaches by Millemaggi, Alessia, Taylor, Richard J. K.

“…The structures and biological activities of naturally occurring 3‐alkenyl‐oxindoles are reviewed. Important man‐made3‐alkenyl‐oxindoles are covered,…”
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Tandem Oxidation Processes Using Manganese Dioxide:  Discovery, Applications, and Current Studies by Taylor, Richard J. K, Reid, Mark, Foot, Jonathan, Raw, Steven A

“…“One-pot” processes in which alcohol oxidations are combined with further elaboration of the carbonyl intermediate are reviewed. Sequential processes are…”
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Consensus and variations in opinions on delirium care: a survey of European delirium specialists by Morandi, A, Davis, D, Taylor, J K, Bellelli, G, Olofsson, B, Kreisel, S, Teodorczuk, A, Kamholz, B, Hasemann, W, Young, J, Agar, M, de Rooij, S E, Meagher, D, Trabucchi, M, MacLullich, A M

“…There are still substantial uncertainties over best practice in delirium care. The European Delirium Association (EDA) conducted a survey of its members and…”
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Simple Palladium(II) Precatalyst for Suzuki−Miyaura Couplings:  Efficient Reactions of Benzylic, Aryl, Heteroaryl, and Vinyl Coupling Partners by Burns, Michael J, Fairlamb, Ian J. S, Kapdi, Anant R, Sehnal, Petr, Taylor, Richard J. K

“…trans-PdBr(N-Succ)(PPh3)2 (1) is a universally effective precatalyst for Suzuki−Miyaura cross-couplings of benzylic halides with aryl- or heteroarylboronic…”
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Transition-Metal-Mediated Routes to 3,3-Disubstituted Oxindoles through Anilide Cyclisation by Klein, Johannes E. M. N., Taylor, Richard J. K.

“…This review describes transition‐metal‐catalysed and ‐mediated processes for the preparation of oxindoles from anilides through C(3)–C(3a) bond formation…”
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Total Synthesis of an Oxepine Natural Product, (±)-Janoxepin by Doveston, Richard G, Steendam, René, Jones, Stuart, Taylor, Richard J. K

“…The total synthesis of (±)-janoxepin, a novel antiplasmodial d-leucine derived oxepine-pyrimidinone-ketopiperazine isolated from the fungus Aspergillus janus,…”
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Oxindole synthesis by direct C-H, Ar-H coupling by Perry, Alexis, Taylor, Richard J K

“…A novel copper(II)-mediated route for the conversion of anilides into 3,3-disubstituted-oxindoles is described which proceeds via a formal C-H, Ar-H coupling…”
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Silica-Supported Silver Nitrate as a Highly Active Dearomatizing Spirocyclization Catalyst: Synergistic Alkyne Activation by Silver Nanoparticles and Silica by Clarke, Aimee K., James, Michael J., O'Brien, Peter, Taylor, Richard J. K., Unsworth, William P.

“…Silica‐supported AgNO3 (AgNO3–SiO2) catalyzes the dearomatizing spirocyclization of alkyne‐tethered aromatics far more effectively than the analogous…”
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