Search Results - "TAYLOR, John A"

Metabolic Flexibility in Cancer: Targeting the Pyruvate Dehydrogenase Kinase:Pyruvate Dehydrogenase Axis by Woolbright, Benjamin L, Rajendran, Ganeshkumar, Harris, Robert A, Taylor, 3rd, John A

“…Cancer cells use alterations of normal metabolic processes to sustain proliferation indefinitely. Transcriptional and posttranscriptional control of the…”
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Genomic heterogeneity in bladder cancer: challenges and possible solutions to improve outcomes by Meeks, Joshua J., Al-Ahmadie, Hikmat, Faltas, Bishoy M., Taylor, John A., Flaig, Thomas W., DeGraff, David J., Christensen, Emil, Woolbright, Benjamin L., McConkey, David J., Dyrskjøt, Lars

“…Histological and molecular analyses of urothelial carcinoma often reveal intratumoural and intertumoural heterogeneity at the genomic, transcriptional and…”
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The Role of Pyruvate Dehydrogenase Kinase-4 (PDK4) in Bladder Cancer and Chemoresistance by Woolbright, Benjamin L, Choudhary, Dharamainder, Mikhalyuk, Andrew, Trammel, Cassandra, Shanmugam, Sambantham, Abbott, Erika, Pilbeam, Carol C, Taylor, 3rd, John A

“…Advanced bladder cancer remains a major source of mortality, with poor treatment options. Cisplatin-based chemotherapy is the standard treatment, however many…”
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Revisiting the role of peritectics in grain refinement of Al alloys by Wang, Feng, Liu, Zhilin, Qiu, Dong, Taylor, John A., Easton, Mark A., Zhang, Ming-Xing

“…The grain refining effect of four peritectic-forming solutes (Ti, V, Zr and Nb) as well as three eutectic-forming solutes (Cu, Mg and Si) on pure Al was…”
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What Is the Significance of Variant Histology in Urothelial Carcinoma? by Lobo, Niyati, Shariat, Shahrokh F., Guo, Charles Chuanhai, Fernandez, Mario I., Kassouf, Wassim, Choudhury, Ananya, Gao, Jianjun, Williams, Stephen B., Galsky, Matthew D., Taylor, John A., Roupret, Morgan, Kamat, Ashish M.

“…Urothelial carcinoma can exhibit a wide range of variant morphologies. Many variants present diagnostic challenges and carry clinical implications that inform…”
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The grain refining mechanism of cast zinc through silver inoculation by Liu, Zhilin, Qiu, Dong, Wang, Feng, Taylor, John A., Zhang, Mingxing

“…Silver (Ag) inoculation was found to significantly reduce the average grain size of cast zinc (Zn) by up to 90%. The mechanism of such grain refinement in cast…”
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Detrusor Underactivity: Clinical Features and Pathogenesis of an Underdiagnosed Geriatric Condition by Taylor III, John A., Kuchel, George A.

“…Urinary incontinence and other lower urinary tract symptoms exert a major influence on the health and independence of frail older people. Detrusor…”
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Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting by Hagbom, Marie, Istrate, Claudia, Engblom, David, Karlsson, Thommie, Rodriguez-Diaz, Jesus, Buesa, Javier, Taylor, John A, Loitto, Vesa-Matti, Magnusson, Karl-Eric, Ahlman, Håkan, Lundgren, Ove, Svensson, Lennart

“…Rotavirus (RV) is the major cause of severe gastroenteritis in young children. A virus-encoded enterotoxin, NSP4 is proposed to play a major role in causing RV…”
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Preclinical models of bladder cancer: BBN and beyond by Matye, David, Leak, Juliann, Woolbright, Benjamin L, Taylor, 3rd, John A

“…Preclinical modelling is a crucial component of advancing the understanding of cancer biology and therapeutic development. Several models exist for…”
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Tumor M2-PK: A novel urine marker of bladder cancer by Liu, Weiya, Woolbright, Benjamin L, Pirani, Karim, Didde, Ryan, Abbott, Erika, Kaushik, Gaurav, Martin, Paige, Hamilton-Reeves, Jill, Taylor, 3rd, John A, Holzbeierlein, Jeffrey M, Anant, Shrikant, Lee, Eugene K

“…Bladder cancer is a "Warburg-like" tumor characterized by a reliance on aerobic glycolysis and expression of pyruvate kinase M2 (PKM2). PKM2 oscillates between…”
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Understanding the microbiome as a mediator of bladder cancer progression and therapeutic response by Golshani, Mahgol, Taylor, John A., Woolbright, Benjamin L.

“…•The microbiome plays critical roles in immune response to cancer.•Broader efforts are needed to better define the gut and urinary microbiomes.•Microbial…”
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MIF family proteins in genitourinary cancer: tumorigenic roles and therapeutic potential by Penticuff, Justin C., Woolbright, Benjamin L., Sielecki, Thais M., Weir, Scott J., Taylor, John A.

“…Genitourinary cancers encompass some of the most common solid tumours and have high rates of morbidity and mortality. Inflammation is associated with enhanced…”
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Metabolic changes in bladder cancer by Woolbright, Benjamin L., Ayres, Matthew, Taylor, John A.

“…Bladder cancer is a common solid tumor. Outcomes are poor in advanced disease, with few novel clinical therapeutics introduced over the previous several…”
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The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition by Mishra, Sanket J, Liu, Weiya, Beebe, Kristin, Banerjee, Monimoy, Kent, Caitlin N, Munthali, Vitumbiko, Koren, John, Taylor, John A, Neckers, Leonard M, Holzbeierlein, Jeffrey, Blagg, Brian S. J

“…The 90 kD heat shock proteins (Hsp90) are molecular chaperones that are responsible for the folding of select proteins, many of which are directly associated…”
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Demographic and clinical profile of an inception cohort of road trauma survivors by Pei, Lulu X, Chan, Herbert, Shum, Leona K, Jae, Lina, Staples, John A, Taylor, John A, Harris, Devin R, Brubacher, Jeffrey R

“…Road trauma is a major public health concern, often resulting in reduced health-related quality of life and prolonged absenteeism from work even after…”
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Macrophage migratory inhibitory factor promotes bladder cancer progression via increasing proliferation and angiogenesis by Choudhary, Shilpa, Hegde, Poornima, Pruitt, James R, Sielecki, Thais M, Choudhary, Dharamainder, Scarpato, Kristen, Degraff, David J, Pilbeam, Carol C, Taylor, 3rd, John A

“…Macrophage migratory inhibitory factor (MIF) is a proinflammatory cytokine shown to promote tumorigenesis. Using the N-butyl-N-(4-hydroxybutyl)-nitrosamine…”
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Role of MIF1/MIF2/CD74 interactions in bladder cancer by Woolbright, Benjamin L, Rajendran, Ganeshkumar, Abbott, Erika, Martin, Austin, Amalraj, Sarah, Dennis, Katie, Li, Xiaogang, Warrick, Joshua, Taylor, John A

“…Macrophage migration inhibitory factor (MIF1) is a pleiotropic cytokine involved in inflammation and cancer. Genetic knockout of Mif1 in the validated…”
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Loss of FOXA1 Drives Sexually Dimorphic Changes in Urothelial Differentiation and Is an Independent Predictor of Poor Prognosis in Bladder Cancer by Reddy, Opal L, Cates, Justin M, Gellert, Lan L, Crist, Henry S, Yang, Zhaohai, Yamashita, Hironobu, Taylor, John A, Smith, Joseph A, Chang, Sam S, Cookson, Michael S, You, Chaochen, Barocas, Daniel A, Grabowska, Magdalena M, Ye, Fei, Wu, Xue-Ru, Yi, Yajun, Matusik, Robert J, Kaestner, Klaus H, Clark, Peter E, DeGraff, David J

“…We previously found loss of forkhead box A1 (FOXA1) expression to be associated with aggressive urothelial carcinoma of the bladder, as well as increased tumor…”
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A Simple and Efficient Synthesis of an Acid-Labile Polyphosphoramidate by Organobase-Catalyzed Ring-Opening Polymerization and Transformation to Polyphosphoester Ionomers by Acid Treatment by Zhang, Shiyi, Wang, Hai, Shen, Yuefei, Zhang, Fuwu, Seetho, Kellie, Zou, Jiong, Taylor, John-Stephen A, Dove, Andrew P, Wooley, Karen L

“…The direct synthesis of an acid-labile polyphosphoramidate by organobase-catalyzed ring-opening polymerization and an overall two-step preparation of…”
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Evidence for Reverse Hoogsteen Hairpin Intermediates in the Photocrosslinking of Human Telomeric DNA Sequences by Lu, Chen, Smith‐Carpenter, Jillian E., Taylor, John‐Stephen A.

“…UVB irradiation of human telomeric d(GGGTTA)3GGG sequences in potassium ion solution crosslinks the first and third TTA segments through anti cyclobutane…”
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