Search Results - "TAYLOR, Charles W"

A Phase I and Pharmacokinetic Study of Oral Lapatinib Administered Once or Twice Daily in Patients with Solid Malignancies by Burris, 3rd, Howard A, Taylor, Charles W, Jones, Suzanne F, Koch, Kevin M, Versola, Melissa J, Arya, Niki, Fleming, Ronald A, Smith, Deborah A, Pandite, Lini, Spector, Neil, Wilding, George

“…Purpose: This study determined the range of tolerable doses, clinical safety, pharmacokinetics, and preliminary evidence of clinical activity following once or…”
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Hormone-Refractory Breast Cancer Remains Sensitive to the Antitumor Activity of Heat Shock Protein 90 Inhibitors by BELIAKOFF, Jason, BAGATELL, Rochelle, PAINE-MURRIETA, Gillian, TAYLOR, Charles W, LYKKESFELDT, Anne E, WHITESELL, Luke

“…Purpose: The antiestrogen tamoxifen (Tam) has been used as therapy against estrogen receptor (ER)-positive breast cancer for decades. Most tumors respond…”
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Early Increases in Breast Tumor Xenograft Water Mobility in Response to Paclitaxel Therapy Detected by Non-Invasive Diffusion Magnetic Resonance Imaging by Galons, Jean-Philippe, Altbach, Maria I., Paine-Murrieta, Gillian D., Taylor, Charles W., Gillies, Robert J.

“…An important goal in cancer chemotherapy is to sensitively and quantitatively monitor the response of individual patients' tumors to successful, or…”
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Induction of a Heat Shock Factor 1-dependent Stress Response Alters the Cytotoxic Activity of Hsp90-binding Agents by BAGATELL, R, PAINE-MURRIETA, G. D, TAYLOR, C. W, PULCINI, E. J, AKINAGA, S, BENJAMIN, I. J, WHITESELL, L

“…In addition to its classic role in the cellular stress response, heat shock protein 90 (Hsp90) plays a critical but less well appreciated role in regulating…”
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Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer by BAGATELL, Rochelle, KHAN, Omar, PAINE-MURRIETA, Gillian, TAYLOR, Charles W, AKINAGA, Shiro, WHITESELL, Luke

“…Steroid hormone receptors have become an important target in the management of breast cancers. Despite a good initial response rate, however, most tumors…”
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Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells by GALLEGOS, A, GASDASKA, J. R, TAYLOR, C. W, PAINE-MURRIETA, G. D, GOODMAN, D, GASDASKA, P. Y, BERGGREN, M, BRIEHL, M. M, POWIS, G

“…Thioredoxin, a redox protein with growth factor activity that modulates the activity of several proteins important for cell growth, has been reported to be…”
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A phase I and pharmacodynamic evaluation of polyethylene glycol-conjugated L-asparaginase in patients with advanced solid tumors by TAYLOR, Charles W, DORR, Robert T, FANTA, Paul, HERSH, Evan M, SALMON, Sydney E

“…To evaluate the in vitro activity of polyethylene glycol-conjugated L-asparaginase (PEG-Lasparaginase) against fresh human tumor specimens, using the human…”
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Randomized trial of adjuvant human interferon gamma versus observation in high-risk cutaneous melanoma: a Southwest Oncology Group study by Meyskens, Jr, F L, Kopecky, K J, Taylor, C W, Noyes, R D, Tuthill, R J, Hersh, E M, Feun, L G, Doroshow, J H, Flaherty, L E, Sondak, V K

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Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase by LEMKE, L. E, PAINE-MURRIETA, G. D, TAYLOR, C. W, POWIS, G

“…Phosphatidylinositol (PtdIns) 3-kinase is an important mediator of many cellular functions. The study of PtdIns 3-kinase has been facilitated by the existence…”
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Combination chemotherapy with cyclophosphamide, vincristine, adriamycin, and dexamethasone (CVAD) plus oral quinine and verapamil in patients with advanced breast cancer by TAYLOR, C. W, DALTON, W. S, MOSLEY, K, DORR, R. T, SALMON, S. E

“…We evaluated the question of whether the chemosensitizers verapamil and quinine given orally to breast cancer patients failing combination chemotherapy alone…”
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Phase II evaluation of interleukin-4 in patients with non-Hodgkinʼs lymphoma: a Southwest Oncology Group Trial by Taylor, Charles W, LeBlanc, Michael, Fisher, Richard I, Moore, Dennis F, Roach, Ralph W, Elias, Laurence, Miller, Thomas P

“…We performed a phase II, Southwest Oncology Group (SWOG) clinical trial of recombinant human interleukin-4 (rhuIL-4) in patients with previously treated…”
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Phase III study of APF530 versus ondansetron with a neurokinin 1 antagonist + corticosteroid in preventing highly emetogenic chemotherapy-induced nausea and vomiting: MAGIC trial by Schnadig, Ian D., Agajanian, Richy, Dakhil, Shaker R., Gabrail, Nashat Y., Smith, Robert E., Taylor, Charles W., Wilks, Sharon, Cooper, William, Mosier, Michael, Payne, Yvette, Klepper, Michael, Vacirca, Jeffrey L.

“…Abstract only 68 Background: Managing chemotherapy-induced nausea and vomiting (CINV) associated with delayed ( > 24-120 h) highly emetogenic chemotherapy…”
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Inhibition of colon tumor cell growth by 8-chloro-cAMP is dependent upon its conversion to 8-chloro-adenosine by Taylor, C W, Yeoman, L C

“…Recent interest in site-selective cAMP analogs has focused on the role of 8-chloro-adenosine (8-Cl-adenosine) in the inhibition of tumor cell growth by…”
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Alteration of human tumor cell adhesion by high-strength static magnetic fields by Short, W O, Goodwill, L, Taylor, C W, Job, C, Arthur, M E, Cress, A E

“…The authors investigated whether the ability of human malignant melanoma cells to increase in cell number or their ability to remain viable was compromised by…”
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Occurrence of cytosolic protein and phosphoprotein changes in human colon tumor cells with the development of resistance to mitomycin C by TAYLOR, C. W, BRATTAIN, M. G, YEOMAN, L. C

“…The cytosolic proteins and phosphoproteins of a mitomycin C-sensitive cell line were examined as progressively greater doses of mitomycin C were administered…”
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Treatment of Small-Cell Lung Cancer by Taylor, C W

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Multicenter randomized clinical trial of goserelin versus surgical ovariectomy in premenopausal patients with receptor-positive metastatic breast cancer: an intergroup study by Taylor, C W, Green, S, Dalton, W S, Martino, S, Rector, D, Ingle, J N, Robert, N J, Budd, G T, Paradelo, J C, Natale, R B, Bearden, J D, Mailliard, J A, Osborne, C K

“…To compare failure-free survival (FFS) and overall survival (OS) for patients with metastatic breast cancer treated with the gonadotropin-releasing hormone…”
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Ethno-/Xeno- Views of Other-/Own- Cultures: Comments on Haas and White by Taylor, Charles W.

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Diaryl chalcogenides as selective inhibitors of thioredoxin reductase and potential antitumor agents by Engman, L, Cotgreave, I, Angulo, M, Taylor, C W, Paine-Murrieta, G D, Powis, G

“…Thioredoxin reductase is a selenocysteine containing flavoenzyme that catalyzes the NADPH dependent reduction of the redox protein thioredoxin. Thioredoxin is…”
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Synthesis of the non-K-region and K-region trans-dihydrodiols of benzo[e]pyrene by Lehr, Roland E, Taylor, Charles W, Kumar, Subah, Mah, He Duck, Jerina, Donald M

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