Search Results - "TAYLOR, Charles P"

Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use by Taylor, Charles P, Traynelis, Stephen F, Siffert, Joao, Pope, Laura E, Matsumoto, Rae R

“…Dextromethorphan (DM) has been used for more than 50years as an over-the-counter antitussive. Studies have revealed a complex pharmacology of DM with…”
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The diverse therapeutic actions of pregabalin: is a single mechanism responsible for several pharmacological activities? by Stahl, Stephen M, Porreca, Frank, Taylor, Charles P, Cheung, Raymond, Thorpe, Andrew J, Clair, Andrew

“…Pregabalin is a specific ligand of the alpha2 -delta (α2 -δ) auxiliary subunit of voltage-gated calcium channels. A growing body of evidence from studies of…”
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Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C by Fehrenbacher, Jill C, Taylor, Charles P, Vasko, Michael R

“…Gabapentin and pregabalin are amino acid derivatives of γ-amino butyric acid that have anticonvulsant, analgesic, and anxiolytic-like properties in animal…”
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Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons by Micheva, Kristina D, Taylor, Charles P, Smith, Stephen J

“…Pregabalin [S-[+]-3-isobutylGABA or (S)-3-(aminomethyl)-5-methylhexanoic acid, Lyrica] is an anticonvulsant and analgesic medication that is both structurally…”
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Calcium channel alpha2-delta type 1 subunit is the major binding protein for pregabalin in neocortex, hippocampus, amygdala, and spinal cord : An ex vivo autoradiographic study in alpha2-delta type 1 genetically modified mice by FENG BIAN, ZHENG LI, OFFORD, James, DUFF DAVIS, M, MCCORMICK, Julie, TAYLOR, Charles P, WALKER, Lary C

“…Pregabalin is a synthetic amino acid compound effective in clinical trials for the treatment of post-herpetic neuralgia, diabetic peripheral neuropathy,…”
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Anxiolytic-like activity of pregabalin in the Vogel conflict test in α2δ-1 (R217A) and α2δ-2 (R279A) mouse mutants by Lotarski, Susan M, Donevan, Sean, El-Kattan, Ayman, Osgood, Sarah, Poe, Julie, Taylor, Charles P, Offord, James

“…The α(2)δ auxiliary subunits (α(2)δ-1 and α(2)δ-2) of voltage-sensitive calcium channels are thought to be the site of action of pregabalin (Lyrica), a drug…”
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Anxiolytic profile of pregabalin on elicited hippocampal theta oscillation by Siok, Chester J., Taylor, Charles P., Hajós, Mihály

“…Previous published work with the novel anticonvulsant, analgesic and anti-anxiety medication, pregabalin (Lyrica ®), has shown that it has anxiolytic-like…”
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Analgesia with Gabapentin and Pregabalin May Involve N -Methyl-d-Aspartate Receptors, Neurexins, and Thrombospondins by Taylor, Charles P., Harris, Eric W.

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Pharmacology and mechanism of action of pregabalin: The calcium channel α2 –δ (alpha2 –delta) subunit as a target for antiepileptic drug discovery by Taylor, Charles P, Angelotti, Timothy, Fauman, Eric

“…Summary Pregabalin (Lyrica™) is a new antiepileptic drug that is active in animal seizure models. Pregabalin is approved in US and Europe for adjunctive…”
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Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia by HURLEY, Robert W, CHATTERJEA, Debika, FENG, Meihua Rose, TAYLOR, Charles P, HAMMOND, Donna L

“…Gabapentin and pregabalin are anticonvulsants with antihyperalgesic effects in animal models of neuropathic and inflammatory nociception. This study…”
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Activity profile of pregabalin in rodent models of epilepsy and ataxia by Vartanian, Mark G., Radulovic, Louis L., Kinsora, Jack J., Serpa, Kevin A., Vergnes, Marguerite, Bertram, Edward, Taylor, Charles P.

“…Pregabalin (Lyrica™) is a novel amino acid compound that binds with high affinity to the alpha 2–delta (α 2–δ) auxiliary protein of voltage-gated calcium…”
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A summary of mechanistic hypotheses of gabapentin pharmacology by Taylor, Charles P, Gee, Nicolas S, Su, Ti-Zhi, Kocsis, Jeffery D, Welty, Devin F, Brown, Jason P, Dooley, David J, Boden, Philip, Singh, Lakhbir

“…Although the cellular mechanisms of pharmacological actions of gabapentin (Neurontin ®) remain incompletely described, several hypotheses have been proposed…”
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Pregabalin is a potent and selective ligand for α₂δ-1 and α₂δ-2 calcium channel subunits by Li, Zheng, Taylor, Charles P, Weber, Mark, Piechan, Julie, Prior, Faith, Bian, Feng, Cui, Mei, Hoffman, Diane, Donevan, Sean

“…Pregabalin, a synthetic branched chain γ-amino acid with anticonvulsant, anxiolytic, and analgesic activities, has been shown to bind with high affinity to the…”
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Pregabalin is a potent and selective ligand for α(2)δ-1 and α(2)δ-2 calcium channel subunits by Li, Zheng, Taylor, Charles P, Weber, Mark, Piechan, Julie, Prior, Faith, Bian, Feng, Cui, Mei, Hoffman, Diane, Donevan, Sean

“…Pregabalin, a synthetic branched chain γ-amino acid with anticonvulsant, anxiolytic, and analgesic activities, has been shown to bind with high affinity to the…”
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Rodent model of chronic central pain after spinal cord contusion injury and effects of gabapentin by Hulsebosch, C E, Xu, G Y, Perez-Polo, J R, Westlund, K N, Taylor, C P, McAdoo, D J

“…Spinal cord injury (SCI) often results in abnormal pain syndromes in patients. We present a recently developed SCI mammalian model of chronic central pain in…”
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Oxadiazolone bioisosteres of pregabalin and gabapentin by Wustrow, David J., Belliotti, Thomas R., Capiris, Thomas, Kneen, Clare O., Bryans, Justin S., Field, Mark J., Williams, Dic, El-Kattan, Ayman, Buchholz, Lisa, Kinsora, Jack J., Lotarski, Susan M., Vartanian, Mark G., Taylor, Charles P., Donevan, Sean D., Thorpe, Andrew J., Schwarz, Jacob B.

“…A series of oxadiazolone bioisosteres of pregabalin 1 and gabapentin 2 were prepared, and several were found to exhibit similar potency for the α 2-δ subunit…”
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Pregabalin action at a model synapse : Binding to presynaptic calcium channel α2-δ subunit reduces neurotransmission in mice by JOSHI, Indu, TAYLOR, Charles P

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Structure−Activity Relationships of Pregabalin and Analogues That Target the α2-δ Protein by Belliotti, Thomas R, Capiris, Thomas, Ekhato, I. Victor, Kinsora, Jack J, Field, Mark J, Heffner, Thomas G, Meltzer, Leonard T, Schwarz, Jacob B, Taylor, Charles P, Thorpe, Andrew J, Vartanian, Mark G, Wise, Lawrence D, Zhi-Su, Ti, Weber, Mark L, Wustrow, David J

“…Pregabalin exhibits robust activity in preclinical assays indicative of potential antiepileptic, anxiolytic, and antihyperalgesic clinical efficacy. It binds…”
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Mechanisms of analgesia by gabapentin and pregabalin – Calcium channel α2-δ [Cavα2-δ] ligands by Taylor, Charles P.

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Synchronous Neural Afterdischarges in Rat Hippocampal Slices without Active Chemical Synapses by Taylor, Charles P., Dudek, F. Edward

“…Extracellular field potential and intracellular recordings from neurons in rat hippocampus show that, even with synaptic transmission blocked, antidromic…”
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