Search Results - "TAWARAIANI, Takeharu"

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  1. 1
    新規頻尿・尿失禁治療剤 (±)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydtoxy-2-phenylacetate monohydrochloride monohydrate (NS-21) のイヌにおける12力月間反復経口投与毒性試験ならびに2力月間回復試験

    新規頻尿・尿失禁治療剤 (±)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydtoxy-2-phenylacetate monohydrochloride monohydrate (NS-21) のイヌにおける12力月間反復経口投与毒性試験ならびに2力月間回復試験 by 吉田, 勝, 河南, 明孝, 俵谷, 武治, 石橋, 成太良, 中沢, 素邦, 岡, 高明, 北山, 英太, 安達, 孝浩, 岩倉, 啓子, 鷲見, 信好

    “…NS-21を0, 3, 17.5および100mg/kgの投与用量でイヌに12力月間反復経口投与し, さらに同投与群について2力月間の回復試験を実施して, 以下の成績を得た。1. 一般臨床検査では, 死亡は全ての投与群でみられず, 散瞳, 嘔吐, 体重の減少ないしは増加抑制が17.5mg/kg以上の投与群で,…”
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    A 12-MONTH ORAL REPEATED DOSE TOXICITY STUDY OF (±)-4-DIETHYLAMINO-1, 1-DIMETHYLBUT-2-YN-1-YL 2-CYCLOHEXYL-2-HYDROXY-2-PHENYLACETATE MONOHYDROCHLORIDE MONOHYDRATE (NS-21), A NOVEL DRUG FOR URINARY FREQUENCY AND INCONTINENCE, IN DOGS FOLLOWED BY A 2-MONTH RECOVERY TEST

    A 12-MONTH ORAL REPEATED DOSE TOXICITY STUDY OF (±)-4-DIETHYLAMINO-1, 1-DIMETHYLBUT-2-YN-1-YL 2-CYCLOHEXYL-2-HYDROXY-2-PHENYLACETATE MONOHYDROCHLORIDE MONOHYDRATE (NS-21), A NOVEL DRUG FOR URINARY FREQUENCY AND INCONTINENCE, IN DOGS FOLLOWED BY A 2-MONTH RECOVERY TEST by YOSHIDA, Masaru, KAWAMINAMI, Akitaka, TAWARAIANI, Takeharu, ISHIBASHI, Seitaro, NAKAZAWA, Motokuni, KITAYAMA, Eita, OKA, Takaaki, ADACHI, Takahiro, WAKURA, Keiko, SUMI, Nobuyoshi

    Published in Journal of toxicological sciences (1997)
    “…A 12-month oral repeated dose toxicity study of (±)-4-diethylamino-1, 1-dimethylbut-2-yn-1-y1 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride…”
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