Search Results - "TAVERNA, Pietro"

Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study by Issa, Jean-Pierre J, Prof, Roboz, Gail, Prof, Rizzieri, David, Prof, Jabbour, Elias, MD, Stock, Wendy, Prof, O'Connell, Casey, MD, Yee, Karen, MD, Tibes, Raoul, MD, Griffiths, Elizabeth A, MD, Walsh, Katherine, MD, Daver, Naval, MD, Chung, Woonbok, PhD, Naim, Sue, BS, Taverna, Pietro, PhD, Oganesian, Aram, PhD, Hao, Yong, MD, Lowder, James N, MD, Azab, Mohammad, MD, Kantarjian, Hagop, Prof

“…Summary Background Hypomethylating agents are used to treat cancers driven by aberrant DNA methylation, but their short half-life might limit their activity,…”
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Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia by Chen, Lisa S., Redkar, Sanjeev, Taverna, Pietro, Cortes, Jorge E., Gandhi, Varsha

“…Pim kinases are Ser/Thr kinases with multiple substrates that affect survival pathways. These proteins are overexpressed in acute myeloid leukemia (AML) blasts…”
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Vecabrutinib inhibits B-cell receptor signal transduction in chronic lymphocytic leukemia cell types with wild-type or mutant Bruton tyrosine kinase by Aslan, Burcu, Hubner, Stefan Edward, Fox, Judith A, Taverna, Pietro, Wierda, William G, Kornblau, Steven M, Gandhi, Varsha

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The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer by Fang, Fang, Munck, Joanne, Tang, Jessica, Taverna, Pietro, Wang, Yinu, Miller, David F B, Pilrose, Jay, Choy, Gavin, Azab, Mohammad, Pawelczak, Katherine S, VanderVere-Carozza, Pamela, Wagner, Michael, Lyons, John, Matei, Daniela, Turchi, John J, Nephew, Kenneth P

“…To investigate SGI-110 as a "chemosensitizer" in ovarian cancer and to assess its effects on tumor suppressor genes (TSG) and chemoresponsiveness-associated…”
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Phase Ib dose-escalation study of the selective, non-covalent, reversible Bruton's tyrosine kinase inhibitor vecabrutinib in B-cell malignancies by Allan, John N, Pinilla-Ibarz, Javier, Gladstone, Douglas E, Patel, Krish, Sharman, Jeff P, Wierda, William G, Choi, Michael Y, O'Brien, Susan M, Shadman, Mazyar, Davids, Matthew S, Pagel, John M, Yimer, Habte A, Ward, Renee, Acton, Gary, Taverna, Pietro, Combs, Daniel L, Fox, Judith A, Furman, Richard R, Brown, Jennifer R

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Immunomodulatory action of the DNA methyltransferase inhibitor SGI-110 in epithelial ovarian cancer cells and xenografts by Srivastava, Pragya, Paluch, Benjamin E, Matsuzaki, Junko, James, Smitha R, Collamat-Lai, Golda, Taverna, Pietro, Karpf, Adam R, Griffiths, Elizabeth A

“…We aimed to determine the effect of SGI-110 on methylation and expression of the cancer testis antigens (CTAs) NY-ESO-1 and MAGE-A in epithelial ovarian cancer…”
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Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine by Albany, Costantine, Hever-Jardine, Mary P, von Herrmann, Katherine M, Yim, Christina Y, Tam, Janice, Warzecha, Joshua M, Shin, Leah, Bock, Sarah E, Curran, Brian S, Chaudhry, Aneeq S, Kim, Fred, Sandusky, George E, Taverna, Pietro, Freemantle, Sarah J, Christensen, Brock C, Einhorn, Lawrence H, Spinella, Michael J

“…Testicular germ cell tumors (TGCTs) are the most common cancers of young males. A substantial portion of TGCT patients are refractory to cisplatin. There are…”
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Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes by Mumenthaler, Shannon M, Ng, Patricia Y B, Hodge, Amanda, Bearss, David, Berk, Gregory, Kanekal, Sarath, Redkar, Sanjeev, Taverna, Pietro, Agus, David B, Jain, Anjali

“…The serine/threonine family of Pim kinases function as oncogenes and have been implicated in prostate cancer progression, particularly in hormone-refractory…”
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Immunomodulatory activity of SGI-110, a 5-aza-2′-deoxycytidine-containing demethylating dinucleotide by Coral, Sandra, Parisi, Giulia, Nicolay, Hugues J. M. G., Colizzi, Francesca, Danielli, Riccardo, Fratta, Elisabetta, Covre, Alessia, Taverna, Pietro, Sigalotti, Luca, Maio, Michele

“…Purpose Pharmacologic DNA hypomethylation holds strong promises in cancer immunotherapy due to its immunomodulatory activity on neoplastic cells. Searching for…”
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Immunomodulatory Properties of DNA Hypomethylating Agents: Selecting the Optimal Epigenetic Partner for Cancer Immunotherapy by Fazio, Carolina, Covre, Alessia, Cutaia, Ornella, Lofiego, Maria Fortunata, Tunici, Patrizia, Chiarucci, Carla, Cannito, Sara, Giacobini, Gianluca, Lowder, James N, Ferraldeschi, Roberta, Taverna, Pietro, Di Giacomo, Anna Maria, Coral, Sandra, Maio, Michele

“…DNA hypomethylating agents (DHAs) play a well-acknowledged role in potentiating the immunogenicity and the immune recognition of neoplastic cells. This…”
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Decitabine Treatment of Glioma-Initiating Cells Enhances Immune Recognition and Killing by Riccadonna, Cristina, Yacoub Maroun, Céline, Vuillefroy de Silly, Romain, Boehler, Margaux, Calvo Tardón, Marta, Jueliger, Simone, Taverna, Pietro, Barba, Leticia, Marinari, Eliana, Pellegatta, Serena, Bassoy, Esen Yonca, Martinvalet, Denis, Dietrich, Pierre-Yves, Walker, Paul R

“…Malignant gliomas are aggressive brain tumours with very poor prognosis. The majority of glioma cells are differentiated (glioma-differentiated cells: GDCs),…”
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The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model by VanderPorten, Erica C, Taverna, Pietro, Hogan, Jennifer N, Ballinger, Marcus D, Flanagan, W Michael, Fucini, Raymond V

“…Aurora kinases play key roles in regulating centrosome maturation, mitotic spindle formation, and cytokinesis during cell division, and are considered…”
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Erratum to: Targeting MET kinase with the small-molecule inhibitor amuvatinib induces cytotoxicity in primary myeloma cells and cell lines by Phillip, Cornel Joseph, Zaman, Shadia, Shentu, Shujun, Balakrishnan, Kumudha, Zhang, Jiexin, Baladandayuthapani, Veera, Taverna, Pietro, Redkar, Sanjeev, Wang, Michael, Stellrecht, Christine Marie, Gandhi, Varsha

“…After the publication of this work [1], it was brought to our attention that two points needed to be explained further. The first point was regarding the GAPDH…”
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Pharmacologic Disruption of Base Excision Repair Sensitizes Mismatch Repair-deficient and -proficient Colon Cancer Cells to Methylating Agents by LIU, L, TAVERNA, P, WHITACRE, C. M, CHATTERJEE, S, GERSON, S. L

“…Previously we showed that a mismatch repair (MMR)-deficient cell line, HCT116 (hMLH1 mut), unlike a MMR wild-type cell line, SW480, was more resistant to the…”
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Abstract 1067: PDK-1 targeting with SNS-510 in sarcoma by Musi, Elgilda, Taverna, Pietro, Schwartz, Gary K.

“…Abstract Soft tissue sarcomas are heterogeneous mesenchymal neoplasms and account for 1% of all cancers in adults. Over 50 sarcomas subtypes have been…”
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Activity of Selinexor As a Single Agent and Synergistic Activity with Approved/Investigational Myelofibrosis Therapies in Vitro by Maloof, Marie E E, Wu, Stephen, Ellero, Andrea, Walker, Christopher J, Kye, Steve, Taverna, Pietro

“…Background: Myelofibrosis (MF) is a myeloproliferative neoplasm (MPN) that commonly harbors acquired somatic gene mutations in JAK2, CALR or MPL leading to…”
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Molecular Pathways: At the Crossroads of Cancer Epigenetics and Immunotherapy by Maio, Michele, Covre, Alessia, Fratta, Elisabetta, Di Giacomo, Anna Maria, Taverna, Pietro, Natali, Pier Giorgio, Coral, Sandra, Sigalotti, Luca

“…Epigenetic regulation allows heritably modulating gene expression profiles without modifying the primary sequence of gDNA. Under physiologic conditions,…”
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Epigenetic Targeting of Ovarian Cancer Stem Cells by YINU WANG, CARDENAS, Horacio, FANG FANG, CONDELLO, Salvatore, TAVERNA, Pietro, SEGAR, Matthew, YUNLONG LIU, NEPHEW, Kenneth P, MATEI, Daniela

“…Emerging results indicate that cancer stem-like cells contribute to chemoresistance and poor clinical outcomes in many cancers, including ovarian cancer. As…”
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Selinexor Plus Ruxolitinib in JAK Inhibitor (JAKi)-Naïve Patients with Myelofibrosis: Long Term Follow up from XPORT-MF-034 Suggestive of Disease Modification by Tantravahi, Srinivas K., Kishtagari, Ashwin, Maher, Keri, Mohan, Sanjay, Prchal, Josef T., Wang, Xulong, Chamoun, Kamal, Walker, Christopher J, Taverna, Pietro, Ali, Haris

“…Background: Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by splenomegaly, constitutional symptoms, and inflammation due to unregulated,…”
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Efficacy of Vecabrutinib Treatment in a Murine Model of Sclerodermatous Graft-Versus-Host-Disease by Maharaj, Kamira, Mediavilla-Varela, Melanie, Uriepero, Angimar, Fox, Judith A., Taverna, Pietro, Gamal, Wael, Sahakian, Eva, Pinilla Ibarz, Javier

“…Introduction. Chronic graft-versus-host disease (cGVHD) can manifest as a complication in patients following allogeneic hematopoietic stem cell transplant…”
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