Search Results - "TAVELIN, Staffan"

Exploring the Role of Different Drug Transport Routes in Permeability Screening by Matsson, Pär, Bergström, Christel A. S, Nagahara, Naoki, Tavelin, Staffan, Norinder, Ulf, Artursson, Per

“…The influence of different drug transport routes in intestinal drug permeability screening assays was studied. Three experimental models were compared:  the…”
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A new principle for tight junction modulation based on occludin peptides by Tavelin, Staffan, Hashimoto, Kei, Malkinson, John, Lazorova, Lucia, Toth, Istvan, Artursson, Per

“…The aim of this study was to investigate whether peptides from the extracellular loops of the tight junction protein occludin could be used as a new principle…”
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Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers by TAVELIN, Staffan, TAIPALENSUU, Jan, SÖDERBERG, Lauri, MORRISON, Rick, SAEHO CHONG, ARTURSSON, Per

“…To characterize the paracellular route of 2/4/A1 monolayers and to compare the permeabilities of incompletely absorbed oral drugs in 2/4/A1 with those in…”
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Applications of epithelial cell culture in studies of drug transport by Tavelin, Staffan, Gråsjö, Johan, Taipalensuu, Jan, Ocklind, Göran, Artursson, Per

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A conditionally immortalized epithelial cell line for studies of intestinal drug transport by Tavelin, S, Milovic, V, Ocklind, G, Olsson, S, Artursson, P

“…A new cell culture model that better mimics the permeability of the human small intestine was developed for studies of passive drug transport. The intestinal…”
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Chitosan in situ gelation for improved drug loading and retention in poloxamer 407 gels by Ur-Rehman, Tofeeq, Tavelin, Staffan, Gröbner, Gerhard

“…Double syringe based in situ ionotropic gelation of chitosan with TPP enhances the drug loading and controlled release profile of P407 gels. A method for the…”
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Effect of DMSO on micellization, gelation and drug release profile of Poloxamer 407 by Ur-Rehman, Tofeeq, Tavelin, Staffan, Gröbner, Gerhard

“…The application of many recently developed or approved drugs and pharmaceuticals is seriously hampered by their low solubility in aqueous media. Hence,…”
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Dissolution and precipitation behavior of ternary solid dispersions of ezetimibe in biorelevant media by Alhayali, Amani, Tavellin, Staffan, Velaga, Sitaram

“…The effects of different formulations and processes on inducing and maintaining the supersaturation of ternary solid dispersions of ezetimibe (EZ) in two…”
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Caco-2 permeability of weakly basic drugs predicted with the double-sink PAMPA pKa(flux) method by Avdeef, Alex, Artursson, Per, Neuhoff, Sibylle, Lazorova, Lucia, Gråsjö, Johan, Tavelin, Staffan

“…The aim of this study was to analyze pH-dependent permeability of cationic drugs in Caco-2 cell monolayers using the pK(a)(flux) method and to correlate the…”
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Interaction of a Poly(acrylic acid) Oligomer with Dimyristoylphosphatidylcholine Bilayers by Filippov, Andrey, Munavirov, Bulat, Sparrman, Tobias, Ishmuhametova, Valentina, Rudakova, Maya, Shriram, Prashant, Tavelin, Staffan

“…We studied the influence of 5 kDa poly(acrylic acid) (PAA) on the phase state, thermal properties, and lateral diffusion in bilayered systems of…”
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A characterisation study on the application of inverted lyotropic phases for subcutaneous drug release by Rosenbaum, Erik, Tavelin, Staffan, Johansson, Lennart B.-Å.

“…An experimental characterisation of lipid mixtures consisting of inverted hexagonal and inverted cubic phases composed of soybean phosphatidylcholine (SPC) and…”
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Contribution of the paracellular route to the pH-dependent epithelial permeability to cationic drugs by Nagahara, Naoki, Tavelin, Staffan, Artursson, Per

“…The aim of this work was to investigate the contribution of the paracellular route to the pH-dependent permeability to cationic drugs in three models…”
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Exploring the quantitative relationship between the level of MDR1 transcript, protein and function using digoxin as a marker of MDR1-dependent drug efflux activity by Taipalensuu, Jan, Tavelin, Staffan, Lazorova, Lucia, Svensson, Ann-Cathrin, Artursson, Per

“…A limited number of gene expression studies have investigated the quantitative relationships between the amount of transcript, level of protein or…”
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An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: Characterization of transport routes by TAVELIN, Staffan, TAIPALENSUU, Jan, HALLBÖÖK, Finn, VELLONEN, Kati-Sisko, MOORE, Vanessa, ARTURSSON, Per

“…To improve the viability of the 2/4/A1 cell culture model and to investigate different routes of drug transport in this cell line. Two approaches were taken to…”
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Interaction of a Poly(acrylic acid) Oligomer with Dimyristoylphosphatidylcholine Bilayers by FLLIPPOV, Mdrey, MUNAVIROV, Bulat, SPARRMAN, Tobias, ISHMUHAMETOVA, Valentina, RUDAKOVA, Maya, SHRIRAM, Prashant, TAVELIN, Staffan

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Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA method by Avdeef, Alex, Artursson, Per, Neuhoff, Sibylle, Lazorova, Lucia, Gråsjö, Johan, Tavelin, Staffan

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Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA p K a flux method by Avdeef, Alex, Artursson, Per, Neuhoff, Sibylle, Lazorova, Lucia, Gråsjö, Johan, Tavelin, Staffan

“…The aim of this study was to analyze pH-dependent permeability of cationic drugs in Caco-2 cell monolayers using the p K a flux method and to correlate the…”
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Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA pKfluxa method by AVDEEF, Alex, ARTURSSON, Per, NEUHOFF, Sibylle, LAZOROVA, Lucia, GRASJÖ, Johan, TAVELIN, Staffan

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Caco-2 permeability of weakly basic drugs predicted with the Double-Sink PAMPA pK flux a method by Avdeef, Alex, Artursson, Per, Neuhoff, Sibylle, Lazorova, Lucia, Gråsjö, Johan, Tavelin, Staffan

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Exploring the quantitative relationship between the level of MDR1 transcript, protein and function using digoxin as a marker of MDR1-dependent drug efflux activity: Membrane transporters by TAIPALENSUU, Jan, TAVELIN, Staffan, LAZOROVA, Lucia, SVENSSON, Ann-Cathrin, ARTURSSON, Per

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