Search Results - "TAUNTON, Jack"

Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes by Shao, Sichen, Murray, Jason, Brown, Alan, Taunton, Jack, Ramakrishnan, V., Hegde, Ramanujan S.

“…In eukaryotes, accurate protein synthesis relies on a family of translational GTPases that pair with specific decoding factors to decipher the mRNA code on…”
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Gait modifications to change lower extremity gait biomechanics in runners: a systematic review by Napier, Christopher, Cochrane, Christopher K, Taunton, Jack E, Hunt, Michael A

“…Abnormal biomechanics have been cited as a potential risk factor for running-related injury. Many modifiable biomechanical risk factors have also been proposed…”
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Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90 by Cuesta, Adolfo, Wan, Xiaobo, Burlingame, Alma L, Taunton, Jack

“…Targeted covalent modification of surface-exposed lysines is challenging due to their low intrinsic reactivity and high prevalence throughout the proteome…”
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Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis by Shah, Priya S., Link, Nichole, Jang, Gwendolyn M., Sharp, Phillip P., Zhu, Tongtong, Swaney, Danielle L., Johnson, Jeffrey R., Von Dollen, John, Ramage, Holly R., Satkamp, Laura, Newton, Billy, Hüttenhain, Ruth, Petit, Marine J., Baum, Tierney, Everitt, Amanda, Laufman, Orly, Tassetto, Michel, Shales, Michael, Stevenson, Erica, Iglesias, Gabriel N., Shokat, Leila, Tripathi, Shashank, Balasubramaniam, Vinod, Webb, Laurence G., Aguirre, Sebastian, Willsey, A. Jeremy, Garcia-Sastre, Adolfo, Pollard, Katherine S., Cherry, Sara, Gamarnik, Andrea V., Marazzi, Ivan, Taunton, Jack, Fernandez-Sesma, Ana, Bellen, Hugo J., Andino, Raul, Krogan, Nevan J.

“…Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a growing public health concern. Systems-level analysis of how…”
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Functional knee brace use for 21 h leads to a longer duration to achieve peak vertical ground reaction forces and the removal of the brace after 17.5 h results in faster loading of the knee joint by Rishiraj, Neetu, Taunton, Jack E., Lloyd‐Smith, Rob, Regan, William, Niven, Brian, Woollard, Robert

“…Purpose To investigate the landing strategies used after discontinuing and continuing the use of a functional knee brace (FKB) while performing a drop jump…”
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Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking by Wan, Xiaobo, Yang, Tangpo, Cuesta, Adolfo, Pang, Xiaming, Balius, Trent E, Irwin, John J, Shoichet, Brian K, Taunton, Jack

“…Eukaryotic translation initiation factor 4E (eIF4E) binds the m7GTP cap structure at the 5′-end of mRNAs, stimulating the translation of proteins implicated in…”
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What are the perceptions about running and knee joint health among the public and healthcare practitioners in Canada? by Esculier, Jean-Francois, Krowchuk, Natasha M, Li, Linda C, Taunton, Jack E, Hunt, Michael A

“…To evaluate the perceptions of the general public and healthcare practitioners (HCP) in Canada about the relationship between running and knee joint health,…”
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Mycolactone subverts immunity by selectively blocking the Sec61 translocon by Baron, Ludivine, Paatero, Anja Onerva, Morel, Jean-David, Impens, Francis, Guenin-Macé, Laure, Saint-Auret, Sarah, Blanchard, Nicolas, Dillmann, Rabea, Niang, Fatoumata, Pellegrini, Sandra, Taunton, Jack, Paavilainen, Ville O, Demangel, Caroline

“…Mycolactone, an immunosuppressive macrolide released by the human pathogen Mycobacterium ulcerans, was previously shown to impair Sec61-dependent protein…”
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Selective Targeting of Distinct Active Site Nucleophiles by Irreversible Src-Family Kinase Inhibitors by Gushwa, Nathan N, Kang, Sumin, Chen, Jing, Taunton, Jack

“…Src-family tyrosine kinases play pivotal roles in human physiology and disease, and several drugs that target members of this family are in clinical use. None…”
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Iliotibial band syndrome rehabilitation in female runners: a pilot randomized study by McKay, Janine, Maffulli, Nicola, Aicale, Rocco, Taunton, Jack

“…Iliotibial band syndrome (ITBS) carries marked morbidity in runners. Its management is not standardized and lacks evidence base. We evaluated the effectiveness…”
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RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation by Roux, Philippe P., Shahbazian, David, Vu, Hieu, Holz, Marina K., Cohen, Michael S., Taunton, Jack, Sonenberg, Nahum, Blenis, John

“…Converging signals from the mammalian target of rapamycin (mTOR) and phosphoinositide 3-kinase (PI3K) pathways are well established to modulate translation…”
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Real-Time Biofeedback of Performance to Reduce Braking Forces Associated With Running-Related Injury: An Exploratory Study by Napier, Christopher, MacLean, Christopher L, Maurer, Jessica, Taunton, Jack E, Hunt, Michael A

“…The high rate of running-related injury may be associated with increased peak braking forces (PBFs) and vertical loading rates. Gait retraining has been…”
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Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel by Paatero, Anja O, Kellosalo, Juho, Dunyak, Bryan M, Almaliti, Jehad, Gestwicki, Jason E, Gerwick, William H, Taunton, Jack, Paavilainen, Ville O

“…Apratoxin A is a cytotoxic natural product that prevents the biogenesis of secretory and membrane proteins. Biochemically, apratoxin A inhibits cotranslational…”
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Myelin Water Fraction Is Transiently Reduced after a Single Mild Traumatic Brain Injury--A Prospective Cohort Study in Collegiate Hockey Players by Wright, Alexander D, Jarrett, Michael, Vavasour, Irene, Shahinfard, Elham, Kolind, Shannon, van Donkelaar, Paul, Taunton, Jack, Li, David, Rauscher, Alexander

“…Impact-related mild traumatic brain injuries (mTBI) are a major public health concern, and remain as one of the most poorly understood injuries in the field of…”
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Using the VERT wearable device to monitor jumping loads in elite volleyball athletes by Damji, Faraz, MacDonald, Kerry, Hunt, Michael A, Taunton, Jack, Scott, Alex

“…Sport is becoming increasingly competitive and athletes are being exposed to greater physical demands, leaving them prone to injuries. Monitoring athletes with…”
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Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization by Rodríguez-Molina, Juan B., Tseng, Sandra C., Simonett, Shane P., Taunton, Jack, Ansari, Aseem Z.

“…During transcription initiation, the TFIIH-kinase Kin28/Cdk7 marks RNA polymerase II (Pol II) by phosphorylating the C-terminal domain (CTD) of its largest…”
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Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors by Cohen, Michael S, Zhang, Chao, Shokat, Kevan M, Taunton, Jack

“…The active sites of 491 human protein kinase domains are highly conserved, which makes the design of selective inhibitors a formidable challenge. We used a…”
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The effect of three different levels of footwear stability on pain outcomes in women runners: a randomised control trial by Ryan, Michael B, Valiant, Gordon A, McDonald, Kymberly, Taunton, Jack E

“…The present study examines the injury status in women runners who are randomised to receive a neutral, stability or motion control running shoe. 81 female…”
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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity by Shahbazian, David, Roux, Philippe P, Mieulet, Virginie, Cohen, Michael S, Raught, Brian, Taunton, Jack, Hershey, John WB, Blenis, John, Pende, Mario, Sonenberg, Nahum

“…The eukaryotic translation initiation factor 4B (eIF4B) plays a critical role in recruiting the 40S ribosomal subunit to the mRNA. In response to insulin,…”
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Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4 by Ogbechi, Joy, Hall, Belinda S., Sbarrato, Thomas, Taunton, Jack, Willis, Anne E., Wek, Ronald C., Simmonds, Rachel E.

“…Mycolactone is the exotoxin virulence factor of Mycobacterium ulcerans that causes the neglected tropical disease Buruli ulcer. We recently showed it to be a…”
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