Clinical and molecular correlates of the ASPECTS in the acute phase of stroke

Clinical and molecular correlates of the ASPECTS in the acute phase of stroke

ABSTRACT Background: The Alberta Stroke Program Early CT Score (ASPECTS) scale was developed for monitoring early ischemic changes on CT, being associated with clinical outcomes. The ASPECTS can also associate with peripheral biomarkers that reflect the pathophysiological response of the brain to th...

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Published in:Arquivos de neuro-psiquiatria Vol. 78; no. 5; pp. 262 - 268
Main Authors: MOURÃO, Aline Mansueto, VICENTE, Laélia Cristina Caseiro, ABREU, Mery Natali Silva, SANT’ANNA, Romeu Vale, DE MEIRA, Fidel Castro Alves, XAVIER, Rodrigo Menezes de Brito, TANURE, Marco Túlio de Azevedo, VIEIRA, Erica Leandro Marciano, DE SOUZA, Leonardo Cruz, MIRANDA, Aline Silva de, RACHID, Milene Alvarenga, TEIXEIRA, Antônio Lucio
Format: Journal Article
Language:English
Published: Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil Thieme Revinter Publicações Ltda 01-05-2020
Arquivos de Neuro-Psiquiatria
Academia Brasileira de Neurologia - ABNEURO
Academia Brasileira de Neurologia (ABNEURO)
Subjects:
Adiponectin
Biomarkers
brain ischemia
Brain-derived neurotrophic factor
Cognitive ability
IL-1β
Ischemia
neurologic examination
Neurological complications
neurology
NEUROSCIENCES
Plasma levels
prognosis
PSYCHIATRY
Stroke
Thrombolysis
Vascular cell adhesion molecule 1
Vascular endothelial growth factor
Neurology
Neurologia
Brain Ischemia
Neurologic Examination
Prognosis
Exame Neurológico
Isquemia Encefálica
Prognóstico
Biomarkers
Biomarcadores
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Summary:ABSTRACT Background: The Alberta Stroke Program Early CT Score (ASPECTS) scale was developed for monitoring early ischemic changes on CT, being associated with clinical outcomes. The ASPECTS can also associate with peripheral biomarkers that reflect the pathophysiological response of the brain to the ischemic stroke. Objective: To investigate the association between peripheral biomarkers with the Alberta Stroke Program Early CT Score (ASPECTS) in individuals after ischemic stroke. Methods: Patients over 18 years old with acute ischemic stroke were enrolled in this study. No patient was eligible for thrombolysis. The patients were submitted to non-contrast CT in the first 24 hours of admission, being the Alberta Stroke Program Early CT Score and clinical and molecular evaluations applied on the same day. The National Institutes of Health Stroke Scale (NIHSS), modified Rankin scale and the Mini-Mental State Examination for clinical evaluation were also applied to all subjects. Plasma levels of BDNF, VCAM-1, VEGF, IL-1β, sTNFRs and adiponectin were determined by ELISA. Results: Worse neurological impairment (NIHSS), cognitive (MEEM) and functional (Rankin) performance was observed in the group with changes in the NCTT. Patients with NCTT changes also exhibited higher levels of IL-1β and adiponectin. In the linear multivariate regression, an adjusted R coefficient of 0.515 was found, indicating adiponectin and NIHSS as independent predictors of ASPECTS. Conclusion: Plasma levels of adiponectin are associated with the ASPECTS scores.
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ISSN:0004-282X
1678-4227
1678-4227
DOI:10.1590/0004-282X20200001