Search Results - "TANSWELL, Paul"

Brain penetration of WEB 2086 (Apafant) and dantrolene in Mdr1a (P-glycoprotein) and Bcrp knockout rats by Fuchs, Holger, Kishimoto, Wataru, Gansser, Dietmar, Tanswell, Paul, Ishiguro, Naoki

“…Transporter gene knockout rat models are attracting increasing interest for mechanistic studies of new drugs as transporter substrates or inhibitors in vivo…”
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Pharmacokinetics and pharmacodynamics of tenecteplase in fibrinolytic therapy of acute myocardial infarction by TANSWELL, Paul, MODI, Nishit, COMBS, Dan, DANAYS, Thierry

“…Tenecteplase is a novel fibrinolytic protein bioengineered from human tissue plasminogen activator (alteplase) for the therapy of acute ST-segment elevation…”
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A Phase I Dose-Escalation Study of Sibrotuzumab in Patients with Advanced or Metastatic Fibroblast Activation Protein-positive Cancer by SCOTT, Andrew M, WISEMAN, Greg, LARSON, Steven M, INGLE, James N, HOFFMAN, Eric W, TANSWELL, Paul, RITTER, Gerd, COHEN, Leonard S, BETTE, Peter, ARVAY, Lisa, AMELSBERG, Andree, VLOCK, Dan, WELT, Sydney, RETTIG, Wolfgang J, OLD, Lloyd J, ADJEI, Alex, LEE, Fook-Thean, HOPKINS, Wendie, DIVGI, Chaitan R, HANSON, Lorelei H, MITCHELL, Paul, GANSEN, Denise N

“…Purpose: The purpose of this research was to determine the safety, immunogenicity, pharmacokinetics, biodistribution, and tumor uptake of repeat infusions of a…”
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Pharmacokinetics and pharmacodynamics of terbogrel, a combined thromboxane A2 receptor and synthase inhibitor, in healthy subjects by Guth, Brian D., Narjes, Hans, Schubert, Hans‐Dieter, Tanswell, Paul, Riedel, Axel, Nehmiz, Gerhard

“…Aims To characterize the pharmacokinetics of terbogrel, a new combined thromboxane A2 (TxA2) receptor and synthase inhibitor, in healthy human subjects after…”
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Single-bolus injection of recombinant tissue-type plasminogen activator in acute myocardial infarction by Tebbe, Ulrich, Tanswell, Paul, Seifried, Erhard, Feuerer, Werner, Scholz, Karl-Heinz, Herrmann, Karlheinz S.

“…Recombinant tissue-type plasminogen activator (rt-PA) has hitherto been administered in acute myocardial infarction as an intravenous infusion with an initial…”
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Nonlinear pharmacokinetics of tissue-type plasminogen activator in three animal species: a comparison of mathematical models by Godfrey, Keith R., Tanswell, Paul, Bates, Ronald A., Chappell, Michael J., Madden, Francis N.

“…A recent study presented plasma concentrations of tissue‐type plasminogen activator in three different animal species and at several different dose levels. A…”
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Pharmacokinetics and pharmacodynamics of terbogrel, a combined thromboxane A 2 receptor and synthase inhibitor, in healthy subjects by Guth, Brian D., Narjes, Hans, Schubert, Hans‐Dieter, Tanswell, Paul, Riedel, Axel, Nehmiz, Gerhard

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Population pharmacokinetics of antifibroblast activation protein monoclonal antibody F19 in cancer patients by Tanswell, Paul, Garin‐Chesa, Pilar, Rettig, Wolfgang J., Welt, Sydney, Divgi, Chaitanya R., Casper, Ephraim S., Finn, Ronald D., Larson, Steven M., Old, Lloyd J., Scott, Andrew M.

“…Aims  The population pharmacokinetics of 131I‐mAbF19, a radiolabelled murine monoclonal antibody against fibroblast activation protein and a potential…”
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Pharmacokinetics and Pharmacodynamics of Tenecteplase: Results from a Phase II Study in Patients with Acute Myocardial Infarction by Modi, Nishit B., Fox, Norma Lynn, Clow, Fong-Wong, Tanswell, Paul, Cannon, Christopher P, Van de Werf, Frans, Braunwald, Eugene

“…Tenecteplase is a site‐specific engineered tissue plasminogen activator (t‐PA) variant that can be administered as a single intravenous bolus injection because…”
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Pharmacokinetics and fibrin specificity of alteplase during accelerated infusions in acute myocardial infarction by Tanswell, Paul, Tebbe, Ulrich, Neuhaus, Karl-Ludwig, Gläsle-Schwarz, Liane, Wojcik, Jaroslaw, Seifried, Erhard

“…Pharmacokinetics and fibrin specificity of alteplase (recombinant tissue-type plasminogen activator) were determined in 10 patients with acute myocardiol…”
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Sixty-Minute Alteplase Protocol: A New Accelerated Recombinant Tissue-Type Plasminogen Activator Regimen for Thrombolysis in Acute Myocardial Infarction by Gulba, Dietrich C, Tanswell, Paul, Dechend, Ralf, Sosada, Markus, Weis, Angelika, Waigand, Jürgen, Uhlich, Frank, Hauck, Sven, Jost, Stefan, Rafflenbeul, Wolf, Lichtlen, Paul R, Dietz, Rainer

“…Objectives. Our aim was to design and evaluate a new and easily administered recombinant tissue-type plasminogen activator (rt-PA) regimen for thrombolysis in…”
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Pharmacokinetics and systemic effects of tissue-type plasminogen activator in normal subjects by Tanswell, P, Seifried, E, Su, P C, Feuerer, W, Rijken, D C

“…Pharmacokinetics and systemic effects of recombinant tissue-type plasminogen activator (rt-PA) were studied in 18 healthy male volunteers after 30-minute…”
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A selective radioimmunoassay for the determination of pirenzepine in plasma and urine by Homon, C A, Esber, H J, Zavorskas, P, Tanswell, P, Farina, P R

“…A radioimmunoassay procedure for the determination of pirenzepine in either plasma or urine was demonstrated to be both sensitive and specific as well as…”
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Nuclear-magnetic-resonance study of the active-site structure of yeast phosphoglycerate kinase by Tanswell, P, Westhead, E.W, Williams, R.J.P

“…The enzyme 3‐phosphoglycerate kinase from yeast has been studied by observation of the proton nuclear magnetic resonance spectrum at 270 MHz using Fourier…”
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Immunological approaches to the structure of fibrinogen by Tanswell, P, Gollwitzer, R, Stan-Lotter, H, Timpl, R

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Structure of antigenic determinants in the amino-terminal region of bovine fibrinogen alpha chain by TANSWELL, Paul, Hildegard, Hildegard, TIMPL, Rupert

“…A radioimmunoassay was developed for peptide F‐CB1α from the amino end of bovine fibrinogen Aα chain, isolated after reduction and carboxymethylation of the…”
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Quantitative Determination of the Conformation of ATP in Aqueous Solution Using the Lanthanide Cations as Nuclear‐Magnetic‐Resonance Probes by TANSWELL, Paul, THORNTON, Janet M., KORDA, Alexander V., WILLIAMS, Robert J. P.

“…Chemical shift perturbations of the eight 1H resonances and of the three 31P resonances in the nuclear magnetic resonance spectra of ATP in 2H2O, pH 6.0, have…”
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Immunochemistry of bovine fibrinogen--III. Localization of two antigenic determinants in fibrinopeptide B by Tanswell, P, Stan-Lotter, H, Gollwitzer, R, Timpl, R

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