Search Results - "TANNENBAUM, S. R"

Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens by Fox, J G, Feng, Y, Theve, E J, Raczynski, A R, Fiala, J L A, Doernte, A L, Williams, M, McFaline, J L, Essigmann, J M, Schauer, D B, Tannenbaum, S R, Dedon, P C, Weinman, S A, Lemon, S M, Fry, R C, Rogers, A B

“…Hepatocellular carcinoma (HCC) frequently results from synergism between chemical and infectious liver carcinogens. Worldwide, the highest incidence of HCC is…”
Get more information

Nitric oxide and TNF-α trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice by Erdman, S.E, Rao, V.P, Poutahidis, T, Rogers, A.B, Taylor, C.L, Jackson, E.A, Ge, Z, Lee, C.W, Schauer, D.B, Wogan, G.N, Tannenbaum, S.R, Fox, J.G

“…Recombinase-activating gene-2-deficient (Rag2⁻/⁻) mice lacking functional lymphocytes provide a useful model of chronic inflammatory bowel disease-emulating…”
Get full text

Chemistry meets biology in colitis-associated carcinogenesis by Mangerich, A, Dedon, P C, Fox, J G, Tannenbaum, S R, Wogan, G N

“…The intestine comprises an exceptional venue for a dynamic and complex interplay of numerous chemical and biological processes. Here, multiple chemical and…”
Get more information

Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer by Wang, C, Gong, G, Sheh, A, Muthupalani, S, Bryant, E M, Puglisi, D A, Holcombe, H, Conaway, E A, Parry, N A P, Bakthavatchalu, V, Short, S P, Williams, C S, Wogan, G N, Tannenbaum, S R, Fox, J G, Horwitz, B H

“…The risk of colon cancer is increased in patients with Crohn’s disease and ulcerative colitis. Inflammation-induced DNA damage could be an important link…”
Get full text

A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction by Sivaraman, A, Leach, J K, Townsend, S, Iida, T, Hogan, B J, Stolz, D B, Fry, R, Samson, L D, Tannenbaum, S R, Griffith, L G

“…In vitro models of the liver using isolated primary hepatocytes have been used as screens for measuring the metabolism, toxicity and efficacy of xenobiotics,…”
Get more information

The Chemistry of the S-Nitrosoglutathione/Glutathione System by Singh, S. P., Wishnok, J. S., Keshive, M., Deen, W. M., Tannenbaum, S. R.

“…S-Nitrosothiols have generated considerable interest due to their ability to act as nitric oxide (NO) donors and due to their possible involvement in…”
Get full text

Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi‐MPS Integration by Yu, J, Cilfone, NA, Large, EM, Sarkar, U, Wishnok, JS, Tannenbaum, SR, Hughes, DJ, Lauffenburger, DA, Griffith, LG, Stokes, CL, Cirit, M

“…Our goal in developing Microphysiological Systems (MPS) technology is to provide an improved approach for more predictive preclinical drug discovery via a…”
Get full text

DNA Damage and Mutation in Human Cells Exposed to Nitric Oxide in vitro by Nguyen, T., Brunson, D., Crespi, C. L., Penman, B. W., Wishnok, J. S., Tannenbaum, S. R.

“…Nitric oxide (NO·) is a physiological messenger formed by several cell types. Reaction with O2forms oxides that nitrosate amines at pH values near 7. We now…”
Get full text

Roles of nitric oxide in inducible resistance of Escherichia coli to activated murine macrophages by NUNOSHIBA, T, DEROJAS-WALKER, T, TANNENBAUM, S. R, DEMPLE, B

“…Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
Get full text

Monocyclic aromatic amines as potential human carcinogens: old is new again by Skipper, Paul L., Kim, Min Young, Sun, H.-L. Patty, Wogan, Gerald N., Tannenbaum, Steven R.

“…Alkylanilines are a group of chemicals whose ubiquitous presence in the environment is a result of the multitude of sources from which they originate. Exposure…”
Get full text

Protein adducts in the molecular dosimetry of chemical carcinogens by Skipper, P L, Tannenbaum, S R

“…Genotoxic carcinogens form covalent bonds with proteins as well as with DNA. The adducts which result are useful for assessing exposure to the carcinogen,…”
Get more information

Activation by Nitric Oxide of an Oxidative-Stress Response that Defends Escherichia coli Against Activated Macrophages by Nunoshiba, Tatsuo, DeRojas-Walker, Teresa, Wishnok, John S., Tannenbaum, Steven R., Demple, Bruce

“…Nitric oxide is a free radical (NO.) formed biologically through the oxidation of L-arginine by nitric oxide synthases. NO.is produced transiently in mammalian…”
Get full text

Oxidation of 2,6-Dimethylaniline by Recombinant Human Cytochrome P450s and Human Liver Microsomes by Gan, Jinping, Skipper, Paul L, Tannenbaum, Steven R

“…2,6-Dimethylaniline (2,6-DMA) is classified as a rodent nasal cavity carcinogen and a possible human carcinogen. The major metabolite of 2,6-DMA in rats and…”
Get full text

Inhibition of nitrosamine formation by ascorbic acid by Tannenbaum, SR, Wishnok, JS, Leaf, CD

“…Nitrosation occurs under a wide variety of conditions by reaction of most types of amines with any of a large number of nitrosating species. Nitrite can be…”
Get full text

Hemoglobin Adducts of Aromatic Amines: Associations with Smoking Status and Type of Tobacco by Bryant, Matthew S., Vineis, Paolo, Skipper, Paul L., Tannenbaum, Steven R.

“…Hemoglobin adducts of 15 aromatic amines were determined in nonsmokers and smokers of blond- or black-tobacco cigarettes living in Turin, Italy. The subjects…”
Get full text

Acetylator phenotype, aminobiphenyl-hemoglobin adduct levels, and bladder cancer risk in white, black, and Asian men in Los Angeles, California by Yu, M C, Skipper, P L, Taghizadeh, K, Tannenbaum, S R, Chan, K K, Henderson, B E, Ross, R K

“…There is a large body of epidemiologic and experimental data that have identified a number of arylamines as human bladder carcinogens. Metabolic activation is…”
Get more information

Etheno adducts in spleen DNA of SJL mice stimulated to overproduce nitric oxide by NAIR, J, GAL, A, TAMIR, S, TANNENBAUM, S. R, WOGAN, G. N, BARTSCH, H

“…In order to investigate specific DNA damage caused by nitric oxide (NO) induced lipid peroxidation, levels of promutagenic etheno adducts…”
Get full text

Recombinational repair is critical for survival of Escherichia coli exposed to nitric oxide by Spek, E J, Wright, T L, Stitt, M S, Taghizadeh, N R, Tannenbaum, S R, Marinus, M G, Engelward, B P

“…Nitric oxide (NO(.)) is critical to numerous biological processes, including signal transduction and macrophage-mediated immunity. In this study, we have…”
Get full text

Plasma arginine, citrulline, and ornithine kinetics in adults, with observations on nitric oxide synthesis by Castillo, L, Sánchez, M, Vogt, J, Chapman, T E, DeRojas-Walker, T C, Tannenbaum, S R, Ajami, A M, Young, V R

“…The plasma fluxes of ornithine (Orn), arginine (Arg), and citrulline (Cit) and rate of conversion of labeled ornithine-to-citrulline (QOrn-->Cit) were…”
Get full text

Splanchnic metabolism of dietary arginine in relation to nitric oxide synthesis in normal adult man by Castillo, L. (Massachusetts Institute of Technology, Cambridge, MA), DeRojas, T.C, Chapman, T.E, Vogt, J, Burke, J.F, Tannenbaum, S.R, Young, V.R

“…Urinary nitrate (NO3) is the stable end product of nitric oxide, which is formed, in turn, from a guanidino nitrogen of arginine. We have conducted two…”
Get full text