Fibromucinous T-cell lymphoma: A new clinicopathologic variant of mycosis fungoides?

Fibromucinous T-cell lymphoma: A new clinicopathologic variant of mycosis fungoides?

We report a case of mycosis fungoides associated with extensive dermal fibrosis and mucin deposition. The patient developed indurated plaques with diffuse tightening of the skin reminiscent of the sclerosing disorder scleromyxedema, which was later associated with nodules and lymphadenopathy. Skin b...

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Bibliographic Details
Published in:The American journal of dermatopathology Vol. 22; no. 6; pp. 515 - 518
Main Authors: FAIRBEE, Sharon I, MORGAN, Michael B, TANNENBAUM, Myron T, GLASS, L. Frank
Format: Journal Article
Language:English
Published: Hagerstown, MD Lippincott Williams & Wilkins 01-12-2000
Subjects:
Antigens, Neoplasm - analysis
Biological and medical sciences
Biomarkers, Tumor - analysis
Dermatology
Diagnosis, Differential
Fibrosis
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Mucins - analysis
Mycosis Fungoides - chemistry
Mycosis Fungoides - pathology
Skin - pathology
Skin Neoplasms - chemistry
Skin Neoplasms - pathology
Tumors of the skin and soft tissue. Premalignant lesions
Human
Immunohistochemistry
Skin disease
Process variant
Mycosis fungoides
Male
Malignant hemopathy
Non Hodgkin lymphoma
Peripheral T cell lymphoma
Case study
Pathology
Cutaneous hematologic disease
Mucin
Lymphoproliferative syndrome
Fibrosis
T-Lymphocyte
Adult
Clinical investigation
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Description
Summary:We report a case of mycosis fungoides associated with extensive dermal fibrosis and mucin deposition. The patient developed indurated plaques with diffuse tightening of the skin reminiscent of the sclerosing disorder scleromyxedema, which was later associated with nodules and lymphadenopathy. Skin biopsies showed diffusely thickened collagen bundles in the dermis and mucin deposition with a dense infiltrate of atypical lymphocytes with an immunophenotypic pattern indicative of mycosis fungoides. In our opinion, these clinical and histopathologic features are unusual for mycosis fungoides and can be construed as a distinct fibromucinous variant. Alternatively, this may represent a fibrosing reaction pattern similar to that described with systemic T- and B-cell lymphomas or a variety of inflammatory disorders.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ISSN:0193-1091
1533-0311
DOI:10.1097/00000372-200012000-00006