Search Results - "TANKE, H. J"
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Array-CGH detection of micro rearrangements in mentally retarded individuals: clinical significance of imbalances present both in affected children and normal parents
Published in Journal of medical genetics (01-02-2006)“…Background: The underlying causes of mental retardation remain unknown in about half the cases. Recent array-CGH studies demonstrated cryptic imbalances in…”
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2
A homozygous deletion of a normal variation locus in a patient with hearing loss from non-consanguineous parents
Published in Journal of medical genetics (01-06-2009)“…International databases with information on copy number variation of the human genome are an important reference for laboratories using high resolution whole…”
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3
Detection of Cell and Tissue Surface Antigens Using Up-Converting Phosphors: A New Reporter Technology
Published in Analytical biochemistry (01-02-1999)“…A novel luminescent reporter for the sensitive detection of antigens in tissue sections or on cell membranes is described. It consists of submicron-size…”
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4
Heterogeneity in Telomere Length of Human Chromosomes
Published in Human molecular genetics (01-05-1996)“…Vertebrate chromosomes terminate in variable numbers of T2AG3 nucleotide repeats. In order to study telomere repeats at individual chromosomes, we developed…”
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Linear 2' O-Methyl RNA probes for the visualization of RNA in living cells
Published in Nucleic acids research (01-09-2001)“…U1snRNA, U3snRNA, 28 S ribosomal RNA, poly(A) RNA and a specific messenger RNA were visualized in living cells with microinjected fluorochrome-labeled 2'…”
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6
Photobleaching kinetics of fluorescein in quantitative fluorescence microscopy
Published in Biophysical journal (01-06-1995)“…An investigation on the photobleaching behavior of fluorescein in microscopy was carried out through a systematic analysis of photobleaching mechanisms. The…”
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7
Identification of Genetic Markers for Prostatic Cancer Progression
Published in Laboratory investigation (01-06-2000)“…Despite the high incidence of prostate cancer, only limited data are available on genes or chromosomes specifically involved in its initiation and progression…”
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New strategy for multi-colour fluorescence in situ hybridisation: COBRA: COmbined Binary RAtio labelling
Published in European journal of human genetics : EJHG (01-01-1999)“…Multicolour in situ hybridisation (MFISH) is increasingly applied to karyotyping and detection of chromosomal abnormalities. So far 27 colour analyses have…”
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Comparative genomic hybridization of cancer of the gastroesophageal junction : Deletion of 14Q31-32.1 discriminates between esophageal (Barrett's) and gastric cardia adenocarcinomas
Published in Cancer research (Chicago, Ill.) (01-02-1999)“…Incidence rates have risen rapidly for esophageal and gastric cardia adenocarcinomas. These cancers, arising at and around the gastroesophageal junction (GEJ),…”
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Molecular and clinical characterization of de novo and familial cases with microduplication 3q29: guidelines for copy number variation case reporting
Published in Cytogenetic and genome research (01-01-2008)“…Microdeletions of 3q29 have previously been reported, but the postulated reciprocal microduplication has only recently been observed. Here, cases from four…”
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COmbined Binary RAtio fluorescence in situ hybridiziation (COBRA-FISH): development and applications
Published in Cytogenetic and genome research (01-08-2006)“…The ability to probe for the location of DNA sequences in morphologically preserved chromosomes and nuclei by fluorescence in situ hybridization (FISH)…”
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Platinum(II)-Based Coordination Compounds as Nucleic Acid Labeling Reagents: Synthesis, Reactivity, and Applications in Hybridization Assays
Published in Chembiochem : a European journal of chemical biology (07-07-2003)“…The synthesis, characterization, and molecular interactions of platinum(II) coordination compounds, which contain a distal nonradioactive reporter molecule,…”
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13
High-resolution DNA Fiber-FISH for genomic DNA mapping and colour bar-coding of large genes
Published in Human molecular genetics (01-05-1995)“…We have applied two-colour fluorescence in situ hybridization (FISH) to DNA fibers and combined it with digital imaging microscopy for the mapping of large…”
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14
Clonal analysis of a case of multifocal oesophageal (Barrett's) adenocarcinoma by comparative genomic hybridization
Published in The Journal of pathology (01-07-1999)“…Oesophageal adenocarcinomas arising in Barrett's epithelium occasionally present as multiple lesions. This could be due to either a multifocal presentation of…”
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15
The feasibility and reliability of sentinel node mapping in colorectal cancer
Published in European journal of surgical oncology (01-10-2005)“…Sentinel node mapping (SNM) has been introduced in colorectal cancer (CRC) to improve staging by facilitating occult tumour cell (OTC) assessment in lymph…”
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16
Characteristics of A spermatogonia and preleptotene spermatocytes in the vitamin A-deficient rat testis
Published in Biology of reproduction (01-09-1995)“…The proliferative activity and other characteristics of germ cells in the vitamin A-deficient (VAD) rat testis were investigated. In the VAD testis, A…”
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17
Prognostic relevance of occult tumour cells in lymph nodes in colorectal cancer
Published in European journal of surgical oncology (01-04-2006)“…Presently, in Europe the treatment of node-negative colorectal cancer (CRC) patients consists of surgical resection of the primary tumour without adjuvant…”
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Ultra-sensitive FISH using peroxidase-mediated deposition of biotin- or fluorochrome tyramides
Published in Human molecular genetics (01-04-1995)“…We describe a detection principle for indirect fluorescence in situ hybridization (FISH) methods that with only one or two antibody layers dramatically…”
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Supervised automated microscopy increases sensitivity and efficiency of detection of sentinel node micrometastases in patients with breast cancer
Published in Journal of clinical pathology (01-09-2004)“…Aims: To investigate the practicality and sensitivity of supervised automated microscopy (AM) for the detection of micrometastasis in sentinel lymph nodes…”
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Cryptic terminal chromosome rearrangements in colorectal carcinoma cell lines detected by subtelomeric FISH analysis
Published in Cytogenetic and genome research (01-08-2006)“…Epithelial tumour karyotypes are often difficult to study by standard cytogenetic methods because of poor chromosome preparation quality and the high…”
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