Search Results - "TANIMOTO, AKIHIDE"

Phenotypic Changes in Macrophage Activation in a Model of Nonalcoholic Fatty Liver Disease using Microminipigs by Yoshii, Daiki, Nakagawa, Takenobu, Komohara, Yoshihiro, Kawaguchi, Hiroaki, Yamada, Sohsuke, Tanimoto, Akihide

“…Aim: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders associated with metabolic syndrome, and its prevalence has…”
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A tailored next‐generation sequencing panel identified distinct subtypes of wildtype IDH and TERT promoter glioblastomas by Higa, Nayuta, Akahane, Toshiaki, Yokoyama, Seiya, Yonezawa, Hajime, Uchida, Hiroyuki, Takajo, Tomoko, Kirishima, Mari, Hamada, Taiji, Matsuo, Kei, Fujio, Shingo, Hanada, Tomoko, Hosoyama, Hiroshi, Yonenaga, Masanori, Sakamoto, Akihisa, Hiraki, Tsubasa, Tanimoto, Akihide, Yoshimoto, Koji

“…Central nervous system tumors are classified based on an integrated diagnosis combining histology and molecular characteristics, including IDH1/2 and H3‐K27M…”
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Spontaneous pulmonary emphysema in mice lacking all three nitric oxide synthase isoforms by Kato, Kaori, Tsutsui, Masato, Noguchi, Shingo, Iha, Yukitoshi, Naito, Keisuke, Ogoshi, Takaaki, Nishida, Chinatsu, Tahara, Masahiro, Yamashita, Hirotaka, Wang, Ke-Yong, Toyohira, Yumiko, Yanagihara, Nobuyuki, Masuzaki, Hiroaki, Shimokawa, Hiroaki, Tanimoto, Akihide, Yatera, Kazuhiro

“…The roles of endogenous nitric oxide (NO) derived from the entire NO synthases (NOSs) system have yet to be fully elucidated. We addressed this issue in mice…”
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Metabolic reprograming of cancer as a therapeutic target by Furukawa, Tatsuhiko, Tabata, Sho, Minami, Kentaro, Yamamoto, Masatatsu, Kawahara, Kohichi, Tanimoto, Akihide

“…Our understanding of metabolic reprogramming in cancer has tremendously improved along with the technical progression of metabolomic analysis. Metabolic…”
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Genome Editing Using Cas9 Ribonucleoprotein Is Effective for Introducing PDGFRA Variant in Cultured Human Glioblastoma Cell Lines by Hamada, Taiji, Yokoyama, Seiya, Akahane, Toshiaki, Matsuo, Kei, Tanimoto, Akihide

“…Many variants of uncertain significance (VUS) have been detected in clinical cancer cases using next-generation sequencing-based cancer gene panel analysis…”
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An oncogenic splice variant of PDGFRα in adult glioblastoma as a therapeutic target for selective CDK4/6 inhibitors by Hamada, Taiji, Akahane, Toshiaki, Yokoyama, Seiya, Higa, Nayuta, Kirishima, Mari, Matsuo, Kei, Shimokawa, Michiko, Yoshimoto, Koji, Tanimoto, Akihide

“…Understanding human genome alterations is necessary to optimize genome-based cancer therapeutics. However, some newly discovered mutations remain as variants…”
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Diffuse distribution of tumor-infiltrating lymphocytes is a marker for better prognosis and chemotherapeutic effect in triple-negative breast cancer by Hida, Akira I., Watanabe, Takahiro, Sagara, Yasuaki, Kashiwaba, Masahiro, Sagara, Yoshiaki, Aogi, Kenjiro, Ohi, Yasuyo, Tanimoto, Akihide

“…Purpose High-density tumor-infiltrating lymphocytes (TILs) are a prognostic marker for triple-negative breast cancer (TNBC). However, lymphocytic infiltration…”
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Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development by Furukawa, Tatsuhiko, Mimami, Kentaro, Nagata, Toshiyuki, Yamamoto, Masatasu, Sato, Masami, Tanimoto, Akihide

“…The circadian rhythm-related genes and have various functions under different cell and tissue conditions. has been reported to be both a cancer-suppressive and…”
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Molecular Genetic Profile of 300 Japanese Patients with Diffuse Gliomas Using a Glioma-tailored Gene Panel by HIGA, Nayuta, AKAHANE, Toshiaki, YOKOYAMA, Seiya, YONEZAWA, Hajime, UCHIDA, Hiroyuki, FUJIO, Shingo, KIRISHIMA, Mari, TAKIGAWA, Kosuke, HATA, Nobuhiro, TOH, Keita, YAMAMOTO, Junkoh, HANAYA, Ryosuke, TANIMOTO, Akihide, YOSHIMOTO, Koji

“…Rapid technological advances in molecular biology, including next-generation sequencing, have identified key genetic alterations in central nervous system…”
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The physiological response during optogenetic-based cardiac pacing in awake freely moving mice by Kaminosono, Jun, Kambe, Yuki, Tanimoto, Akihide, Kuwaki, Tomoyuki, Yamashita, Akira

“…There are several methods to control a heart rate, such as electrical stimulation and drug administration. However, these methods may be invasive or affect…”
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PCP4/PEP19 downregulates neurite outgrowth via transcriptional regulation of Ascl1 and NeuroD1 expression in human neuroblastoma M17 cells by Kitazono, Ikumi, Hamada, Taiji, Yoshimura, Takuya, Kirishima, Mari, Yokoyama, Seiya, Akahane, Toshiaki, Tanimoto, Akihide

“…Purkinje cell protein 4/peptide 19 (PCP4/PEP19) is 7.6 kDa peptide originally found in Purkinje cells. PCP4/PEP19 is a differentiation maker of Purkinje cells,…”
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Targeted next-generation sequencing assays using triplet samples of normal breast tissue, primary breast cancer, and recurrent/metastatic lesions by Akahane, Toshiaki, Kanomata, Naoki, Harada, Oi, Yamashita, Tetsumasa, Kurebayashi, Junichi, Tanimoto, Akihide, Moriya, Takuya

“…Next-generation sequencing (NGS) has shown that recurrent/metastatic breast cancer lesions may have additional genetic changes compared with the primary tumor…”
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MALAT1 functions as a transcriptional promoter of MALAT1::GLI1 fusion for truncated GLI1 protein expression in cancer by Hamada, Taiji, Higashi, Michiyo, Yokoyama, Seiya, Akahane, Toshiaki, Hisaoka, Masanori, Noguchi, Hirotsugu, Furukawa, Tatsuhiko, Tanimoto, Akihide

“…The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a cancer biomarker. Furthermore, fusion of the MALAT1 gene with…”
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Unknown primary malignant small round cell tumor masquerading as acute leukemia by Iwaizako, Hiroki, Nishikawa, Takuro, Kitazono, Ikumi, Tanimoto, Akihide, Okamoto, Yasuhiro

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Comprehensive validation of liquid-based cytology specimens for next-generation sequencing in cancer genome analysis by Akahane, Toshiaki, Yamaguchi, Tomomi, Kato, Yasutaka, Yokoyama, Seiya, Hamada, Taiji, Nishida, Yukari, Higashi, Michiyo, Nishihara, Hiroshi, Suzuki, Shinsuke, Ueno, Shinichi, Tanimoto, Akihide

“…In addition to conventional cytology, liquid-based cytology (LBC) is also used for immunocytochemistry and gene analysis. However, an appropriate method to…”
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Cholic Acid Enhances Visceral Adiposity, Atherosclerosis and Nonalcoholic Fatty Liver Disease in Microminipigs by Yamada, Sohsuke, Kawaguchi, Hiroaki, Yamada, Tomonobu, Guo, Xin, Matsuo, Kei, Hamada, Taiji, Miura, Naoki, Tasaki, Takashi, Tanimoto, Akihide

“…Aim: We have recently established a novel swine model for studies of atherosclerosis using MicrominipigsTM (µMPs) fed a high-fat/high-cholesterol diet (HcD)…”
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Prognosis prediction via histological evaluation of cellular heterogeneity in glioblastoma by Kirishima, Mari, Yokoyama, Seiya, Akahane, Toshiaki, Higa, Nayuta, Uchida, Hiroyuki, Yonezawa, Hajime, Matsuo, Kei, Yamamoto, Junkoh, Yoshimoto, Koji, Hanaya, Ryosuke, Tanimoto, Akihide

“…Glioblastomas (GBMs) are the most aggressive types of central nervous system tumors. Although certain genomic alterations have been identified as prognostic…”
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Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice by Kina-Tanada, Mika, Sakanashi, Mayuko, Tanimoto, Akihide, Kaname, Tadashi, Matsuzaki, Toshihiro, Noguchi, Katsuhiko, Uchida, Taro, Nakasone, Junko, Kozuka, Chisayo, Ishida, Masayoshi, Kubota, Haruaki, Taira, Yuji, Totsuka, Yuichi, Kina, Shin-ichiro, Sunakawa, Hajime, Omura, Junichi, Satoh, Kimio, Shimokawa, Hiroaki, Yanagihara, Nobuyuki, Maeda, Shiro, Ohya, Yusuke, Matsushita, Masayuki, Masuzaki, Hiroaki, Arasaki, Akira, Tsutsui, Masato

“…Aims/hypothesis Nitric oxide (NO) is synthesised not only from l -arginine by NO synthases (NOSs), but also from its inert metabolites, nitrite and nitrate…”
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Eruptive squamous cell carcinoma in a patient treated with concomitant pembrolizumab and imiquimod by Kanekura, Takuro, Arimura, Akiko, Kirishima, Mari, Tanimoto, Akihide

“…Pembrolizumab, a humanized monoclonal antibody against programmed cell death 1, is used for various malignant neoplasms. Toll‐like receptor (TLR) agonists,…”
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Critical in vivo roles of histamine and histamine receptor signaling in animal models of metabolic syndrome by Yamada, Sohsuke, Tanimoto, Akihide, Sasaguri, Yasuyuki

“…Histamine, a classic low‐molecular‐weight amine, is synthesized from L‐histidine by histidine decarboxylase (HDC), and histamine‐specific receptors (HRs) are…”
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