Search Results - "TANAKA, TETSUAKI"

Medicinal chemistry of Annonaceous acetogenins: design, synthesis, and biological evaluation of novel analogues by Kojima, Naoto, Tanaka, Tetsuaki

“…Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty…”
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Asymmetric Total Synthesis of (+)-Danicalipin A by Yoshimitsu, Takehiko, Nakatani, Ryo, Kobayashi, Akihiro, Tanaka, Tetsuaki

“…A convergent asymmetric total synthesis of (+)-danicalipin A is accomplished, in which two chlorinated fragments are stereoselectively joined by 1,3-dipolar…”
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Asymmetric Total Synthesis of (+)-Hexachlorosulfolipid, a Cytotoxin Isolated from Adriatic Mussels by Yoshimitsu, Takehiko, Fukumoto, Naoya, Nakatani, Ryo, Kojima, Naoto, Tanaka, Tetsuaki

“…The enantioselective total synthesis of (+)-hexachlorosulfolipid, a cytotoxin found in the Adriatic mussel Mytilus galloprovincialis, is described. The unique…”
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Total Synthesis of (±)-Kainic Acid: A Photochemical C–H Carbamoylation Approach by Kamon, Takuma, Irifune, Yayoi, Tanaka, Tetsuaki, Yoshimitsu, Takehiko

“…A novel photochemical C–H carbamoylation of an octahydroisoindole derivative with PhNCO has allowed the authors to provide a unique access to a highly…”
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Enantiocontrolled Synthesis of Polychlorinated Hydrocarbon Motifs: A Nucleophilic Multiple Chlorination Process Revisited by Yoshimitsu, Takehiko, Fukumoto, Naoya, Tanaka, Tetsuaki

“…Polychlorinated hydrocarbon motifs have been synthesized in enantiomerically pure forms by means of nucleophilic multiple chlorinations of chiral epoxides,…”
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Double CH Functionalization in Sequential Order: Direct Synthesis of Polycyclic Compounds by a Palladium-Catalyzed CH Alkenylation-Arylation Cascade by Ohno, Hiroaki, Iuchi, Mutsumi, Kojima, Naoto, Yoshimitsu, Takehiko, Fujii, Nobutaka, Tanaka, Tetsuaki

“…Palladium‐catalyzed cascade CH alkenylation and arylation provides convenient access to polycyclic aromatic compounds. Treatment of 3‐bromoaniline derivatives…”
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A Highly Regio- and Stereoselective Formation of Bicyclo[4.2.0]oct-5-ene Derivatives through Thermal Intramolecular [2 + 2] Cycloaddition of Allenes by Ohno, Hiroaki, Mizutani, Tsuyoshi, Kadoh, Yoichi, Aso, Akimasa, Miyamura, Kumiko, Fujii, Nobutaka, Tanaka, Tetsuaki

“…Thermal [2 + 2] cycloaddition of allenes with an additional multiple bond is described. By simply heating the allenenes or allenynes having a three-atom tether…”
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Palladium(0)-Catalyzed Synthesis of Medium-Sized Heterocycles by Using Bromoallenes as an Allyl Dication Equivalent by Ohno, Hiroaki, Hamaguchi, Hisao, Ohata, Miyo, Kosaka, Shohei, Tanaka, Tetsuaki

“…We have developed a highly regio- and stereoselective synthesis of medium-sized heterocycles containing one or two heteroatoms via cyclization of bromoallenes…”
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Thermal Intramolecular [2+2] Cycloaddition of Allenenes and Allenynes: Diastereoselective Access to Bicyclic Nitrogen Heterocycles by Ohno, Hiroaki, Mizutani, Tsuyoshi, Kadoh, Yoichi, Miyamura, Kumiko, Tanaka, Tetsuaki

“…Squaring the circle: A route to bicyclo[4.2.0]octane derivatives has been developed by the [2+2] cycloaddition of allenenes or allenynes. The thermal…”
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Bromoallenes as Allyl Dication Equivalents in the Presence or Absence of Palladium(0): Direct Construction of Bicyclic Sulfamides Containing Five- to Eight-membered Rings by Tandem Cyclization of Bromoallenes by Hamaguchi, Hisao, Kosaka, Shohei, Ohno, Hiroaki, Fujii, Nobutaka, Tanaka, Tetsuaki

“…A highly regioselective synthesis of bicyclic sulfamides is described. Based on our recent discovery that bromoallenes can act as allyl dication equivalents in…”
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Potassium Carbonate-Promoted Stereospecific 5-Endo-Trig Cyclization of Unactivated Allenes in the Absence of Any Transition Metals by Ohno, Hiroaki, Kadoh, Yoichi, Fujii, Nobutaka, Tanaka, Tetsuaki

“…Formation of 3-pyrrolines from simple unactivated allenes bearing a protected amino group under basic conditions is described. Treatment of α-amino allenes…”
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Stereoconvergent route to chiral cyclohexenone building blocks: formal synthesis of (-)-dysidiolide by Moustafa, Gamal A I, Kamada, Yasumasa, Tanaka, Tetsuaki, Yoshimitsu, Takehiko

“…A stereoconvergent access to chiral carbocyclic building blocks is reported. 6-(3'-Hydroxy-4'-methylpent-4'-enyl)-3-methoxy cyclohex-2-enone () that consists…”
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Synthesis of Fused and Linked Bicyclic Nitrogen Heterocycles by Palladium-Catalyzed Domino Cyclization of Propargyl Bromides by Okano, Akinori, Tsukamoto, Koji, Kosaka, Shohei, Maeda, Hatsuo, Oishi, Shinya, Tanaka, Tetsuaki, Fujii, Nobutaka, Ohno, Hiroaki

“…The palladium(0)‐catalyzed direct construction of bicyclic heterocycles is described. Treatment of propargyl bromides that have nucleophilic functional groups…”
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Direct Construction of Bicyclic Heterocycles by Palladium-Catalyzed Domino Cyclization of Propargyl Bromides by Ohno, Hiroaki, Okano, Akinori, Kosaka, Shohei, Tsukamoto, Koji, Ohata, Miyo, Ishihara, Kotaro, Maeda, Hatsuo, Tanaka, Tetsuaki, Fujii, Nobutaka

“…The palladium-catalyzed domino cyclization of propargyl bromides having two nucleophilic functional groups is described. Treatment of…”
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Bromoallenes as Allyl Dication Equivalents in the Absence of Palladium(0): Synthesis of Bicyclic Sulfamides by Tandem Cyclization of Bromoallenes by Hamaguchi, Hisao, Kosaka, Shohei, Ohno, Hiroaki, Tanaka, Tetsuaki

“…Who needs a metal? A highly regioselective synthesis of cyclic sulfamides containing a bicyclo[3.3.0]octane skeleton has been developed (see scheme). The first…”
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Synthesis of (±)-aphanorphine: a new approach to tricyclic 3-benzazepine scaffold using two radical C–C bond-forming reactions by Yoshimitsu, Takehiko, Atsumi, Chie, Iimori, Emiko, Nagaoka, Hiroto, Tanaka, Tetsuaki

“…An expeditious approach to (±)-aphanorphine has been established using readily available starting materials. The present synthesis relies on the direct…”
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Bromoallenes as Synthetic Equivalents of Allyl Dications: Synthesis of Medium-Sized Nitrogen Heterocycles through the Cyclization of Bromoallenes in the Presence of a Palladium(0) Catalyst and an Alcohol by Ohno, Hiroaki, Hamaguchi, Hisao, Ohata, Miyo, Tanaka, Tetsuaki

“…A highly regio‐ and stereoselective synthesis of medium‐sized nitrogen heterocycles has been developed (see scheme), based on the discovery that bromoallenes…”
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Palladium(0)-Catalyzed Tandem Cyclization of Allenenes: Direct Construction of Tricyclic Heterocycles through Aromatic CH Activation by Ohno, Hiroaki, Miyamura, Kumiko, Mizutani, Tsuyoshi, Kadoh, Yoichi, Takeoka, Yusuke, Hamaguchi, Hisao, Tanaka, Tetsuaki

“…Palladium(0)‐catalyzed tandem cyclization of allenenes is described. Treatment of allenenes with an aryl halide, potassium carbonate, and catalytic [Pd(PPh3)4]…”
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Samarium(II)-Promoted Radical Spirocyclization onto an Aromatic Ring by Ohno, Hiroaki, Okumura, Mitsuaki, Maeda, Shin-ichiro, Iwasaki, Hiroki, Wakayama, Ryutaro, Tanaka, Tetsuaki

“…Samarium(II)-mediated spirocyclization onto an aromatic ring was achieved by the reaction of methyl 4-(4-oxoalkyl)benzoates with SmI2 in the presence of i-PrOH…”
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Highly Stereoselective and Stereodivergent Synthesis of Four Types of THF Cores in Acetogenins Using a C4-Chiral Building Block by Maezaki, Naoyoshi, Kojima, Naoto, Asai, Mikito, Tominaga, Hiroaki, Tanaka, Tetsuaki

“…Four stereoisomers of the THF cores, synthetic intermediates of acetogenins, have been synthesized with high diastereoselectivity by asymmetric alkynylation…”
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