Search Results - "TAMANINI, ANNA"
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SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation
Published in Nature communications (10-01-2023)“…As an inherited disorder characterized by severe pulmonary disease, cystic fibrosis could be considered a comorbidity for coronavirus disease 2019. Instead,…”
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2
Mapping the transcriptional machinery of the IL-8 gene in human bronchial epithelial cells
Published in The Journal of immunology (1950) (01-12-2011)“…IL-8 released from bronchial epithelial cells infected with Pseudomonas aeruginosa plays a crucial role in the chronic lung pathology of patients affected by…”
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3
Synthesis and Therapeutic Applications of Iminosugars in Cystic Fibrosis
Published in International journal of molecular sciences (09-05-2020)“…Iminosugars are sugar analogues endowed with a high pharmacological potential. The wide range of biological activities exhibited by these glycomimetics…”
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4
A Peptide Nucleic Acid against MicroRNA miR-145-5p Enhances the Expression of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Calu-3 Cells
Published in Molecules (Basel, Switzerland) (01-01-2018)“…Peptide nucleic acids (PNAs) are very useful tools for gene regulation at different levels, but in particular in the last years their use for targeting…”
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5
Sphingolipids role in the regulation of inflammatory response: From leukocyte biology to bacterial infection
Published in Journal of leukocyte biology (01-03-2018)“…Sphingolipids (SLs) are amphiphilic molecules mainly associated with the external leaflet of eukaryotic plasma membrane, and are structural membrane components…”
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Cross‐talk between CFTR and sphingolipids in cystic fibrosis
Published in FEBS open bio (01-09-2023)“…Cystic fibrosis (CF) is the most common inherited, life‐limiting disorder in Caucasian populations. It is caused by mutations in the gene encoding the cystic…”
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7
Improved Trimethylangelicin Analogs for Cystic Fibrosis: Design, Synthesis and Preliminary Screening
Published in International journal of molecular sciences (01-10-2022)“…A small library of new angelicin derivatives was designed and synthesized with the aim of bypassing the side effects of trimethylangelicin (TMA), a promising…”
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New TMA (4,6,4'-Trimethyl angelicin) Analogues as Anti-Inflammatory Agents in the Treatment of Cystic Fibrosis Lung Disease
Published in International journal of molecular sciences (21-11-2022)“…A series of new-generation TMA (4,6,4'-trimethyl angelicin) analogues was projected and synthetized in order to ameliorate anti-inflammatory activity, with…”
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9
GM1 as Adjuvant of Innovative Therapies for Cystic Fibrosis Disease
Published in International journal of molecular sciences (24-06-2020)“…Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein is expressed at the apical plasma membrane (PM) of different epithelial cells. The most…”
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10
Molecular Mechanism of Action of Trimethylangelicin Derivatives as CFTR Modulators
Published in Frontiers in pharmacology (04-07-2018)“…The psoralen-related compound, 4,6,4'-trimethylangelicin (TMA) potentiates the cAMP/PKA-dependent activation of WT-CFTR and rescues F508del-CFTR-dependent…”
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11
Early diagnosis from newborn screening maximises survival in severe cystic fibrosis
Published in ERJ open research (01-04-2018)“…Newborn screening (NBS) for cystic fibrosis (CF) has been gradually established in several countries, but scant data are available on its long-term effects on…”
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12
β-Sitosterol Reduces the Expression of Chemotactic Cytokine Genes in Cystic Fibrosis Bronchial Epithelial Cells
Published in Frontiers in pharmacology (12-05-2017)“…Extracts from L. seeds, which are widely used as anti-inflammatory remedies in traditional medicine of Northern Africa, were able to inhibit the expression of…”
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13
Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases in Pseudomonas aeruginosa Infection of Cystic Fibrosis Bronchial Epithelial Cells
Published in Mediators of Inflammation (01-01-2017)“…Cystic fibrosis (CF) is the most common autosomal genetic recessive disease caused by mutations of gene encoding for the cystic fibrosis transmembrane…”
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14
A Peptide-Nucleic Acid Targeting miR-335-5p Enhances Expression of Cystic Fibrosis Transmembrane Conductance Regulator ( CFTR ) Gene with the Possible Involvement of the CFTR Scaffolding Protein NHERF1
Published in Biomedicines (26-01-2021)“…(1) Background: Up-regulation of the Cystic Fibrosis Transmembrane Conductance Regulator gene ( ) might be of great relevance for the development of…”
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15
Interaction of Adenovirus Type 5 Fiber with the Coxsackievirus and Adenovirus Receptor Activates Inflammatory Response in Human Respiratory Cells
Published in Journal of Virology (01-11-2006)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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16
Pyrogallol, an active compound from the medicinal plant Emblica officinalis, regulates expression of pro-inflammatory genes in bronchial epithelial cells
Published in International immunopharmacology (10-12-2008)“…The most relevant cause of morbidity and mortality in cystic fibrosis (CF) patients is the lung pathology characterized by chronic infection and inflammation…”
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17
Time Trends in Birth Incidence of Cystic Fibrosis in Two European Areas: Data from Newborn Screening Programs
Published in The Journal of pediatrics (2008)“…Objective To determine the incidence of cystic fibrosis (CF) and its time trends over a 16-year period (1990 to 2005) in 2 European regions with a long history…”
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18
Molecular basis of cystic fibrosis: from bench to bedside
Published in Annals of translational medicine (01-09-2018)“…Cystic fibrosis (CF), is an autosomal recessive disease affecting different organs. The lung disease, characterized by recurrent and chronic bacterial…”
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19
A microRNA signature from serum exosomes of patients with glioma as complementary diagnostic biomarker
Published in Journal of neuro-oncology (2018)“…Malignant gliomas, the most frequent primary brain tumors, are characterized by a dismal prognosis. Reliable biomarkers complementary to neuroradiology in the…”
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20
Treatment of human airway epithelial Calu-3 cells with a peptide-nucleic acid (PNA) targeting the microRNA miR-101-3p is associated with increased expression of the cystic fibrosis Transmembrane Conductance Regulator () gene
Published in European journal of medicinal chemistry (01-01-2021)“…Since the identification of microRNAs (miRNAs) involved in the regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, miRNAs known to…”
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