Search Results - "TAM, Beatrice M"

An interaction network between the SNARE VAMP7 and Rab GTPases within a ciliary membrane-targeting complex by Kandachar, Vasundhara, Tam, Beatrice M, Moritz, Orson L, Deretic, Dusanka

“…The Arf4-rhodopsin complex (mediated by the VxPx motif in rhodopsin) initiates expansion of vertebrate rod photoreceptor cilia-derived light-sensing organelles…”
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Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4 by Mazelova, Jana, Astuto-Gribble, Lisa, Inoue, Hiroki, Tam, Beatrice M, Schonteich, Eric, Prekeris, Rytis, Moritz, Orson L, Randazzo, Paul A, Deretic, Dusanka

“…Dysfunctions of primary cilia and cilia‐derived sensory organelles underlie a multitude of human disorders, including retinal degeneration, yet membrane…”
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The Role of Rhodopsin Glycosylation in Protein Folding, Trafficking, and Light-Sensitive Retinal Degeneration by Tam, Beatrice M, Moritz, Orson L

“…Several mutations in the N terminus of the G-protein-coupled receptor rhodopsin disrupt NXS/T consensus sequences for N-linked glycosylation (located at N2 and…”
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Kinesin family 17 (osmotic avoidance abnormal‐3) is dispensable for photoreceptor morphology and function by Jiang, Li, Tam, Beatrice M., Ying, Guoxing, Wu, Sen, Hauswirth, William W., Frederick, Jeanne M., Moritz, Orson L., Baehr, Wolfgang

“…ABSTRACT In Caenorhabditis elegans, homodimeric [kinesin family (KIF) 17, osmotic avoidance abnormal‐3 (OSM‐3)] and heterotrimeric (KIF3) kinesin‐2 motors are…”
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Modeling Dominant and Recessive Forms of Retinitis Pigmentosa by Editing Three Rhodopsin-Encoding Genes in Xenopus Laevis Using Crispr/Cas9 by Feehan, Joanna M., Chiu, Colette N., Stanar, Paloma, Tam, Beatrice M., Ahmed, Sheikh N., Moritz, Orson L.

“…The utility of Xenopus laevis , a common research subject for developmental biology, retinal physiology, cell biology, and other investigations, has been…”
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Germline CRISPR/Cas9-Mediated Gene Editing Prevents Vision Loss in a Novel Mouse Model of Aniridia by Mirjalili Mohanna, Seyedeh Zeinab, Hickmott, Jack W., Lam, Siu Ling, Chiu, Nina Y., Lengyell, Tess C., Tam, Beatrice M., Moritz, Orson L., Simpson, Elizabeth M.

“…Aniridia is a rare eye disorder, which is caused by mutations in the paired box 6 (PAX6) gene and results in vision loss due to the lack of a long-term…”
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Synchronized Photoactivation of T4K Rhodopsin Causes a Chromophore-Dependent Retinal Degeneration That Is Moderated by Interaction with Phototransduction Cascade Components by Tam, Beatrice M, Burns, Paloma, Chiu, Colette N, Moritz, Orson L

“…Multiple mutations in the gene cause sector retinitis pigmentosa in humans and a corresponding light-exacerbated retinal degeneration (RD) in animal models…”
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Identification of an Outer Segment Targeting Signal in the COOH Terminus of Rhodopsin Using Transgenic Xenopus laevis by Tam, Beatrice M., Moritz, Orson L., Hurd, Lawrence B., Papermaster, David S.

“…Mislocalization of the photopigment rhodopsin may be involved in the pathology of certain inherited retinal degenerative diseases. Here, we have elucidated…”
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Identification and cellular localization in Xenopus laevis photoreceptors of three Peripherin-2 family members, Prph2, Rom1 and Gp2l, which arose from gene duplication events in the common ancestors of jawed vertebrates by Tam, Beatrice M., Taylor, John S., Moritz, Orson L.

“…Rod and cone photoreceptors are named for the distinct morphologies of their outer segment organelles, which are either cylindrical or conical, respectively…”
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Electrophysiological Changes During Early Steps of Retinitis Pigmentosa by Bocchero, Ulisse, Tam, Beatrice M, Chiu, Colette N, Torre, Vincent, Moritz, Orson L

“…The rhodopsin mutation P23H is responsible for a significant portion of autosomal-dominant retinitis pigmentosa, a disorder characterized by rod photoreceptor…”
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The role of subunit assembly in peripherin-2 targeting to rod photoreceptor disk membranes and retinitis pigmentosa by Loewen, Christopher J R, Moritz, Orson L, Tam, Beatrice M, Papermaster, David S, Molday, Robert S

“…Peripherin-2 is a member of the tetraspanin family of membrane proteins that plays a critical role in photoreceptor outer segment disk morphogenesis. Mutations…”
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Photoactivation-induced instability of rhodopsin mutants T4K and T17M in rod outer segments underlies retinal degeneration in X. laevis transgenic models of retinitis pigmentosa by Tam, Beatrice M, Noorwez, Syed M, Kaushal, Shalesh, Kono, Masahiro, Moritz, Orson L

“…Retinitis pigmentosa (RP) is an inherited neurodegenerative disease involving progressive vision loss, and is often linked to mutations in the rhodopsin gene…”
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Dark Rearing Rescues P23H Rhodopsin-Induced Retinal Degeneration in a Transgenic Xenopus laevis Model of Retinitis Pigmentosa: A Chromophore-Dependent Mechanism Characterized by Production of N-Terminally Truncated Mutant Rhodopsin by Tam, Beatrice M, Moritz, Orson L

“…To elucidate the molecular mechanisms underlying the light-sensitive retinal degeneration caused by the rhodopsin mutation P23H, which causes retinitis…”
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Generation and Analysis of Xenopus laevis Models of Retinal Degeneration Using CRISPR/Cas9 by Feehan, Joanna M, Stanar, Paloma, Tam, Beatrice M, Chiu, Colette, Moritz, Orson L

“…Xenopus laevis have proven to be a useful system for rapid generation and analysis of transgenic models of human retinal disease. However, experimental…”
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Opposing Effects of Valproic Acid Treatment Mediated by Histone Deacetylase Inhibitor Activity in Four Transgenic X. laevis Models of Retinitis Pigmentosa by Vent-Schmidt, Ruanne Y J, Wen, Runxia H, Zong, Zusheng, Chiu, Colette N, Tam, Beatrice M, May, Christopher G, Moritz, Orson L

“…Retinitis pigmentosa (RP) is an inherited retinal degeneration (RD) that leads to blindness for which no treatment is available. RP is frequently caused by…”
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Characterization of Rhodopsin P23H-Induced Retinal Degeneration in a Xenopus laevis Model of Retinitis Pigmentosa by Tam, Beatrice M, Moritz, Orson L

“…To investigate the pathogenic mechanisms that underlie retinal degeneration induced by the rhodopsin mutation P23H in a Xenopus laevis model of RP. Transgenic…”
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Dual Role of Lys206−Lys296 Interaction in Human Transferrin N-Lobe:  Iron-Release Trigger and Anion-Binding Site by He, Qing-Yu, Mason, Anne B, Tam, Beatrice M, MacGillivray, Ross T. A, Woodworth, Robert C

“…The unique structural feature of the dilysine (Lys206−Lys296) pair in the transferrin N-lobe (hTF/2N) has been postulated to serve a special function in the…”
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Mutant ELOVL4 that causes autosomal dominant stargardt-3 macular dystrophy is misrouted to rod outer segment disks by Agbaga, Martin-Paul, Tam, Beatrice M, Wong, Jenny S, Yang, Lee Ling, Anderson, Robert E, Moritz, Orson L

“…Autosomal dominant Stargardt macular dystrophy caused by mutations in the Elongation of Very Long Chain fatty acids (ELOVL4) gene results in macular…”
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Targeting of mouse guanylate cyclase 1 ( Gucy2e) to Xenopus laevis rod outer segments by Karan, Sukanya, Tam, Beatrice M., Moritz, Orson L., Baehr, Wolfgang

“…► GFP fused to the entire cytoplasmic region of GC1 targets to rod outer segments. ► This fusion localizes specifically to outer segment disk rims. ► Smaller…”
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Preparation of Xenopus laevis retinal cryosections for electron microscopy by Tam, Beatrice M., Yang, Lee Ling, Bogėa, Tami H., Ross, Bradford, Martens, Garnet, Moritz, Orson L.

“…Transmission electron microscopy is the gold standard for examination of photoreceptor outer segment morphology and photoreceptor outer segment abnormalities…”
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