Search Results - "TALPOS, John C"

Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier? by Burks, Susan M., Rosas-Hernandez, Hector, Alejandro Ramirez-Lee, Manuel, Cuevas, Elvis, Talpos, John C.

“…•SARS-CoV-2 may infect immature olfactory sensory neurons.•Olfactory sensory neurons and the blood brain barrier may allow infection of the brain.•The…”
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A comparison of multiple 5-HT receptors in two tasks measuring impulsivity by Talpos, John C., Wilkinson, Lawrence S., Robbins, Trevor W.

“…Impulsivity has often been assumed to be a unitary construct. However dissociable forms of impulsive behaviour may exist, each with distinct neurochemical…”
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Symptomatic thinking: the current state of Phase III and IV clinical trials for cognition in schizophrenia by Talpos, John C.

“…•Currently there are no novel compounds undergoing PIII or PIV clinical trials for cognition in schizophrenia.•Most clinical research aimed at developing…”
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Early life exposure to extended general anesthesia with isoflurane and nitrous oxide reduces responsivity on a cognitive test battery in the nonhuman primate by Talpos, John C., Chelonis, John J., Li, Mi, Hanig, Joseph P., Paule, Merle G.

“…•Perinatal anesthesia exposure altered performance on a progressive ratio responding task.•Perinatal anesthesia may have altered motivation or motor control in…”
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The effects of long-term methylphenidate administration and withdrawal on progressive ratio responding and T2 MRI in the male rhesus monkey by Liachenko, Serguei, Chelonis, John, Paule, Merle G., Li, Mi, Sadovova, Natalya, Talpos, John C.

“…Methylphenidate is a frequently prescribed drug treatment for Attention-Deficit/Hyperactivity Disorder. However, methylphenidate has a mode of action similar…”
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Evaluating aged mice in three touchscreen tests that differ in visual demands: Impaired cognitive function and impaired visual abilities by Buscher, Nathalie, van Dorsselaer, Pascal, Steckler, Thomas, Talpos, John C.

“…•Age-related impairments in the performance of three touchscreen-based behavioral assays were demonstrated in mice.•Neither Visual Discrimination nor Automated…”
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A touch-screen based paired-associates learning (PAL) task for the rat may provide a translatable pharmacological model of human cognitive impairment by Talpos, John C., Aerts, Nancy, Fellini, Laetitia, Steckler, Thomas

“…The use of touch-screen equipped operant boxes is an increasingly popular approach for modeling human cognition in the rodent. However little data is currently…”
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Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain by Wang, Cheng, Bhutta, Adnan, Zhang, Xuan, Liu, Fang, Liu, Shuliang, Latham, Leah E, Talpos, John C, Patterson, Tucker A, Slikker, William

“…With advances in pediatric and obstetric surgery, pediatric patients are subject to complex procedures under general anesthesia. The effects of anesthetic…”
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Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing by Latham, Leah E, Dobrovolsky, Vasily N, Liu, Shuliang, Talpos, John C, Hanig, Joseph P, Slikker, William, Wang, Cheng, Liu, Fang

“…Neurotoxicity assessments are generally performed using laboratory animals. However, as in vitro neurotoxicity models are continuously refined to reach…”
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Sevoflurane exposure has minimal effect on cognitive function and does not alter microglial activation in adult monkeys by Walters, Jennifer L., Zhang, Xuan, Talpos, John C., Fogle, Charles M., Li, Mi, Chelonis, John J., Paule, Merle G.

“…•An 8-hour exposure to sevoflurane did not cause an increase in neuroinflammation as measured by [18F]-FEPPA in aged monkeys.•Extended exposure to sevoflurane…”
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Opposing effects of glutamatergic and GABAergic pharmacological manipulations on a visual perception task with relevance to schizophrenia by Talpos, John C., Riordan, John, Olley, Joseph, Waddell, Jason, Steckler, Thomas

“…Rationale Numerous psychiatric disorders and neurodegenerative diseases have been associated with differences in visual perception, and it has been proposed…”
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Regions of the basal ganglia and primary olfactory system are most sensitive to neurodegeneration after extended sevoflurane anesthesia in the perinatal rat by Burks, Susan M., Bowyer, John F., Walters, Jennifer L., Talpos, John C.

“…Extended general anesthesia early in life is neurotoxic in multiple species. However, little is known about the temporal progression of neurodegeneration after…”
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Animal models and measures of perceptual processing in Schizophrenia by Siegel, Steven J., Talpos, John C., Geyer, Mark A.

“…•Discusses animal paradigms for assessing perception.•CNTRICS breakout group addressed candidate tests of perception.•Concepts included gain control and visual…”
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Severe Cross-Modal Object Recognition Deficits in Rats Treated Sub-Chronically with NMDA Receptor Antagonists are Reversed by Systemic Nicotine: Implications for Abnormal Multisensory Integration in Schizophrenia by JACKLIN, Derek L, GOEL, Amit, CLEMENTINO, Kyle J, HALL, Alexander W. M, TALPOS, John C, WINTERS, Boyer D

“…Schizophrenia is a complex and debilitating disorder, characterized by positive, negative, and cognitive symptoms. Among the cognitive deficits observed in…”
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Acetyl-l-carnitine does not prevent neurodegeneration in a rodent model of prolonged neonatal anesthesia by Walters, Jennifer L., Chelonis, John J., Fogle, Charles M., Ferguson, Sherry A., Sarkar, Sumit, Paule, Merle G., Talpos, John C.

“…Many studies have shown that prolonged or repeated use of general anesthesia early in life can cause an increase in neurodegeneration and lasting changes in…”
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Animal models and measures of perceptual processing in Schizophrenia : CNTRICS: Modeling psychosis related cognition in animal systems to enhance translational research by SIEGEL, Steven J, TALPOS, John C, GEYER, Mark A

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Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5Modulation of NMDAR Currents by Rook, Jerri M, Xiang, Zixiu, Lv, Xiaohui, Ghoshal, Ayan, Dickerson, Jonathan W, Bridges, Thomas M, Johnson, Kari A, Foster, Daniel J, Gregory, Karen J, Vinson, Paige N, Thompson, Analisa D, Byun, Nellie, Collier, Rebekah L, Bubser, Michael, Nedelcovych, Michael T, Gould, Robert W, Stauffer, Shaun R, Daniels, J Scott, Niswender, Colleen M, Lavreysen, Hilde, Mackie, Claire, Conde-Ceide, Susana, Alcazar, Jesus, Bartolomé-Nebreda, José M, Macdonald, Gregor J, Talpos, John C, Steckler, Thomas, Jones, Carrie K, Lindsley, Craig W, Conn, P Jeffrey

“…Schizophrenia is associated with disruptions inN-methyl-D-aspartate glutamate receptor subtype (NMDAR)-mediated excitatory synaptic signaling. The metabotropic…”
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Biased mGlu 5 -Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu 5 Modulation of NMDAR Currents by Rook, Jerri M., Xiang, Zixiu, Lv, Xiaohui, Ghoshal, Ayan, Dickerson, Jonathan W., Bridges, Thomas M., Johnson, Kari A., Foster, Daniel J., Gregory, Karen J., Vinson, Paige N., Thompson, Analisa D., Byun, Nellie, Collier, Rebekah L., Bubser, Michael, Nedelcovych, Michael T., Gould, Robert W., Stauffer, Shaun R., Daniels, J. Scott, Niswender, Colleen M., Lavreysen, Hilde, Mackie, Claire, Conde-Ceide, Susana, Alcazar, Jesus, Bartolomé-Nebreda, José M., Macdonald, Gregor J., Talpos, John C., Steckler, Thomas, Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey

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Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents by Rook, Jerri M., Xiang, Zixiu, Lv, Xiaohui, Ghoshal, Ayan, Dickerson, Jonathan W., Bridges, Thomas M., Johnson, Kari A., Foster, Daniel J., Gregory, Karen J., Vinson, Paige N., Thompson, Analisa D., Byun, Nellie, Collier, Rebekah L., Bubser, Michael, Nedelcovych, Michael T., Gould, Robert W., Stauffer, Shaun R., Daniels, J. Scott, Niswender, Colleen M., Lavreysen, Hilde, Mackie, Claire, Conde-Ceide, Susana, Alcazar, Jesus, Bartolomé-Nebreda, José M., Macdonald, Gregor J., Talpos, John C., Steckler, Thomas, Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey

“…Schizophrenia is associated with disruptions in N-methyl-D-aspartate glutamate receptor subtype (NMDAR)-mediated excitatory synaptic signaling. The…”
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