Search Results - "TALOS, Flaminia"

Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells by Li, Dun, Marchenko, Natalia D, Schulz, Ramona, Fischer, Victoria, Velasco-Hernandez, Talia, Talos, Flaminia, Moll, Ute M

“…The tight control of wild-type p53 by mainly MDM2 in normal cells is permanently lost in tumors harboring mutant p53, which exhibit dramatic constitutive p53…”
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A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue by Talos, Flaminia, Mitrofanova, Antonina, Bergren, Sarah K., Califano, Andrea, Shen, Michael M.

“…To date, reprogramming strategies for generating cell types of interest have been facilitated by detailed understanding of relevant developmental regulatory…”
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Cortical hypoplasia and ventriculomegaly of p73-deficient mice: Developmental and adult analysis by Medina-Bolívar, Carolina, González-Arnay, Emilio, Talos, Flaminia, González-Gómez, Miriam, Moll, Ute M., Meyer, Gundela

“…ABSTRACT Trp73, a member of the p53 gene family, plays a crucial role in neural development. We describe two main phenotypic variants of p73 deficiency in the…”
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Mitochondrially targeted p53 has tumor suppressor activities in vivo by TALOS, Flaminia, PETRENKO, Oleksi, MENA, Patricio, MOLL, Ute M

“…Complex proapoptotic functions are essential for the tumor suppressor activity of p53. We recently described a novel transcription-independent mechanism that…”
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While p73 is essential, p63 is completely dispensable for the development of the central nervous system by Holembowski, Lena, Schulz, Ramona, Talos, Flaminia, Scheel, Andreas, Wolff, Sonja, Dobbelstein, Matthias, Moll, Ute

“…The ancient p53 paralogs p63 and p73 regulate specific tissue formation, cell survival and cell death via their TA and ΔN isoforms. Targeted disruption of the…”
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Role of the p53 family in stabilizing the genome and preventing polyploidization by Talos, Flaminia, Moll, Ute M

“…Cellular defects resulting in chromosomal instability and aneuploidy are the most common features of human cancers. As a major tumor suppressor and intrinsic…”
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E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression by Palacios, Gustavo, Talos, Flaminia, Nemajerova, Alice, Moll, Ute M, Petrenko, Oleksi

“…To better understand the role of E2F1 in tumor formation, we analyzed spontaneous tumorigenesis in p53-/-E2F1+/+ and p53-/-E2F1-/- mice. We show that the…”
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ECMarker: interpretable machine learning model identifies gene expression biomarkers predicting clinical outcomes and reveals molecular mechanisms of human disease in early stages by Jin, Ting, Nguyen, Nam D, Talos, Flaminia, Wang, Daifeng

“…Abstract Motivation Gene expression and regulation, a key molecular mechanism driving human disease development, remains elusive, especially at early stages…”
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Identification of Causal Genetic Drivers of Human Disease through Systems-Level Analysis of Regulatory Networks by Chen, James C., Alvarez, Mariano J., Talos, Flaminia, Dhruv, Harshil, Rieckhof, Gabrielle E., Iyer, Archana, Diefes, Kristin L., Aldape, Kenneth, Berens, Michael, Shen, Michael M., Califano, Andrea

“…Identification of driver mutations in human diseases is often limited by cohort size and availability of appropriate statistical models. We propose a framework…”
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Abstract 3126: Intratumor heterogeneity and clonal dynamics underlying treatment resistance in prostate cancer by Tshering, Lara F, Luo, Fu, Nguyen, Nam D., Rail, James G., Jin, Ting, Wang, Daifeng, Talos, Flaminia

“…Prostate cancer (PCa) is one of the most common cancers in men worldwide and a leading cause of cancer-related mortality. Though PCa is known to be…”
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Abstract 3076: Clonal dynamics and single cell transcriptomics of prostate luminal epithelial cells in aging and cancer by Luo, Fu, Tshering, Lara F., Tutuska, Karis, Szenk, Mariola, Rubel, Diana, Rail, James, Russ, Savanah, Balázsi, Gábor, Talos, Flaminia

“…Age-related prostate diseases are among the most frequently encountered conditions in the male population and age remains a major risk for prostate cancer…”
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Immune mechanisms shape the clonal landscape during early progression of prostate cancer by Tshering, Lara F., Luo, Fu, Russ, Savanah, Szenk, Mariola, Rubel, Diana, Tutuska, Karis, Rail, James G., Balázsi, Gábor, Shen, Michael M., Talos, Flaminia

“…Understanding the role of the immune microenvironment in modulating intratumor heterogeneity is essential for effective cancer therapies. Using multicolor…”
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Abstract A085: A luminal intermediate cell state maintains long-term prostate homeostasis and contributes to tumorigenesis by Luo, Fu, Tshering, Lara F., Tutuska, Karis, Szenk, Mariola, Rubel, Diana, Rail, James G., Russ, Savanah, Liu, Jingxuan, Nemajerova, Alice, Balázsi, Gábor, Talos, Flaminia

“…Cellular heterogeneity poses tremendous challenges for developing cell-targeted therapies and biomarkers of clinically significant prostate cancer. The origins…”
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Epithelial cell lineage specification during prostate organogenesis and regeneration (210.4) by Shen, Michael, Wang, Zhu, Shibata, Maho, Talos, Flaminia, Chua, Chee Wai, Lei, Ming, Bergren, Sarah

“…The prostate gland is a particularly interesting system for the investigation of cell lineage specification given the central role of androgen signaling in all…”
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Identification of Causal Genetic Drivers of Human Disease through Systems-Level Analysis of Regulatory Networks by Chen, James C., Alvarez, Mariano J., Talos, Flaminia, Dhruv, Harshil, Rieckhof, Gabrielle E., Iyer, Archana, Diefes, Kristin L., Aldape, Kenneth, Berens, Michael, Shen, Michael M., Califano, Andrea

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p63 and canonical Wnt signaling by Talos, Flaminia, Schulz, Ramona, Moll, Ute M

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p63 and canonical Wnt signaling by Talos, Flaminia, Schulz, Ramona, Moll, Ute

“…Comment on: Drewelus I, et al. Cell Cycle 2010; 9(3); In press…”
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p73 Suppresses Polyploidy and Aneuploidy in the Absence of Functional p53 by Talos, Flaminia, Nemajerova, Alice, Flores, Elsa R., Petrenko, Oleksi, Moll, Ute M.

“…Previous studies showed that p53 plays a central role in G1 and DNA damage checkpoints, thus contributing to genomic stability. We show here that p73 also…”
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The alpha/beta carboxyterminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins by Wolff, Sonja, Talos, Flaminia, Palacios, Gustavo, Beyer, Ulrike, Dobbelstein, Matthias, Moll, Ute M.

“…p63, an ancestral transcription factor of the p53 family, has three C-terminal isoforms whose relative in vivo functions are elusive. The p63 gene is essential…”
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Brdm2-an aberrant hypomorphic p63 allele by Talos, F, Wolff, S, Beyer, U, Dobbelstein, M, Moll, U M

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