Search Results - "TALCOTT, Michael"
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1
Feasibility and safety of focused ultrasound-enabled liquid biopsy in the brain of a porcine model
Published in Scientific reports (04-05-2020)“…Although blood-based liquid biopsy is a promising noninvasive technique to acquire a comprehensive molecular tumor profile by detecting cancer-specific…”
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2
Reduction of cell surface attachment in experimental hydrocephalus using a novel ventricular catheter with modified tethered liquid perfluorocarbon
Published in Journal of neurosurgery (01-03-2024)“…Ventriculoperitoneal shunting, the most common treatment for the neurological disorder hydrocephalus, has a failure rate of up to 98% within 10 years of…”
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3
Sonobiopsy for minimally invasive, spatiotemporally-controlled, and sensitive detection of glioblastoma-derived circulating tumor DNA
Published in Theranostics (2022)“…Though surgical biopsies provide direct access to tissue for genomic characterization of brain cancer, they are invasive and pose significant clinical risks…”
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4
Impaired neurogenesis with reactive astrocytosis in the hippocampus in a porcine model of acquired hydrocephalus
Published in Experimental neurology (01-05-2023)“…Hydrocephalus is a neurological disease with an incidence of 0.3–0.7 per 1000 live births in the United States. Ventriculomegaly, periventricular white matter…”
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5
Feasibility and safety assessment of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model
Published in International journal of hyperthermia (01-01-2019)“…Purpose: To evaluate the feasibility and assess safety parameters of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated…”
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6
A novel model of acquired hydrocephalus for evaluation of neurosurgical treatments
Published in Fluids and barriers of the CNS (08-11-2021)“…Many animal models have been used to study the pathophysiology of hydrocephalus; most of these have been rodent models whose lissencephalic cerebral cortex may…”
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Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter
Published in Fluids and barriers of the CNS (22-02-2022)“…Hydrocephalus is a neurological disease with an incidence of 80-125 per 100,000 births in the United States. Neuropathology comprises ventriculomegaly,…”
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Characterization of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-induced large-volume hyperthermia in deep and superficial targets in a porcine model
Published in International journal of hyperthermia (01-01-2020)“…To characterize temperature fields and tissue damage profiles of large-volume hyperthermia (HT) induced by magnetic resonance-guided high-intensity focused…”
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9
Comparison of four energy-based vascular sealing and cutting instruments: A porcine model
Published in Surgical endoscopy (01-02-2008)“…Aim To compare the safety and efficacy of four energy-based vascular sealing and cutting instruments. Methods Blood vessels of various types and diameters were…”
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10
Perils of Intravascular Methylprednisolone Injection into the Vertebral Artery: An Animal Study
Published in Journal of bone and joint surgery. American volume (01-09-2008)“…BackgroundIntravascular injection of particulate steroids during cervical nerve root blocks has been postulated to be a source of catastrophic neurologic…”
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11
Measurement of gut permeability using fluorescent tracer agent technology
Published in Scientific reports (07-09-2017)“…The healthy gut restricts macromolecular and bacterial movement across tight junctions, while increased intestinal permeability accompanies many intestinal…”
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12
Novel spinal instrumentation to enhance osteogenesis and fusion: a preliminary study
Published in Journal of neurosurgery. Spine (01-09-2016)“…OBJECTIVE Instrumented spinal fusion continues to exhibit high failure rates in patients undergoing multilevel lumbar fusion or pseudarthrosis revision; with…”
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13
An autonomous implantable device for the prevention of death from opioid overdose
Published in Science advances (25-10-2024)“…Opioid overdose accounts for nearly 75,000 deaths per year in the United States, now a leading cause of mortality among young people aged 18 to 45 years. At…”
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14
Translational design for limited resource settings as demonstrated by Vent-Lock, a 3D-printed ventilator multiplexer
Published in 3D printing in medicine (14-09-2022)“…Background Mechanical ventilators are essential to patients who become critically ill with acute respiratory distress syndrome (ARDS), and shortages have been…”
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15
Selective versus nonselective arterial clamping during laparoscopic partial nephrectomy: impact upon renal function in the setting of a solitary kidney in a porcine model
Published in Journal of endourology (01-07-2009)“…Laparoscopic partial nephrectomy has emerged as a standard of care for small renal masses. Nevertheless, there remains concern over the potential for…”
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Bronchoscopic Implantation of a Novel Wireless Electromagnetic Transponder in the Canine Lung: A Feasibility Study
Published in International journal of radiation oncology, biology, physics (01-09-2008)“…Purpose The success of targeted radiation therapy for lung cancer treatment is limited by tumor motion during breathing. A real-time, objective, nonionizing,…”
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17
Supplemental Oxygen and Carbon Dioxide Each Increase Subcutaneous and Intestinal Intramural Oxygenation
Published in Anesthesia and analgesia (01-07-2004)“…Oxidative killing by neutrophils, a primary defense against surgical pathogens, is directly related to tissue oxygenation. We tested the hypothesis that…”
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Engraftment of cells from porcine islets of Langerhans following transplantation of pig pancreatic primordia in non-immunosuppressed diabetic rhesus macaques
Published in Organogenesis (01-07-2011)“…Transplantation therapy for human diabetes is limited by the toxicity of immunosuppressive drugs. If toxicity can be minimized, there will still be a shortage…”
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The effects of cavernous nerve grafting following surgically induced loss of erectile function in a large-animal model
Published in Plastic and reconstructive surgery (1963) (01-07-2006)“…Prostate cancer is the second most common cause of cancer deaths in men in the United States. Many patients experience partial or complete loss of erectile…”
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1010-P: In Vivo Evaluation of Novel Long-Term Intravascular Implantable Continuous Blood Glucose Monitor in a Chronic Ovine Model-A Glucotrack Inc. Investigation
Published in Diabetes (New York, N.Y.) (01-06-2024)“…Introduction & Objective: This study provides the first in vivo assessment of Glucotrack's long-term implantable Continuous Blood Glucose Monitor (CBGM) in an…”
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