Search Results - "TALALAY, Paul"

Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention by Liu, Hua, Talalay, Paul

“…Exemestane (6-methyleneandrosta-1,4-diene-3,17-dione) is a synthetic steroidal inhibitor of the aromatase reaction that catalyzes the terminal and…”
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Direct and indirect antioxidant properties of inducers of cytoprotective proteins by Dinkova-Kostova, Albena T, Talalay, Paul

“…Cellular protection against oxidative and electrophile toxicities is provided by two types of small-molecule antioxidants: (i) direct antioxidants, which are…”
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Sulforaphane treatment of autism spectrum disorder (ASD) by Singh, Kanwaljit, Connors, Susan L., Macklin, Eric A., Smith, Kirby D., Fahey, Jed W., Talalay, Paul, Zimmerman, Andrew W.

“…Significance Autism spectrum disorder (ASD), encompassing impaired communication and social interaction, and repetitive stereotypic behavior and language,…”
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Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase by Fahey, Jed W, Holtzclaw, W David, Wehage, Scott L, Wade, Kristina L, Stephenson, Katherine K, Talalay, Paul

“…Glucoraphanin from broccoli and its sprouts and seeds is a water soluble and relatively inert precursor of sulforaphane, the reactive isothiocyanate that…”
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Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways by Brown, Robert H, Reynolds, Curt, Brooker, Allison, Talalay, Paul, Fahey, Jed W

“…It is widely recognized that deep inspiration (DI), either before methacholine (MCh) challenge (Bronchoprotection, BP) or after MCh challenge (Bronchodilation,…”
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Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles by Liu, Hua, Dinkova-Kostova, Albena T, Talalay, Paul

“…An elaborate network of highly inducible phase 2 proteins protects aerobic cells against the cumulative damaging effects of reactive oxygen intermediates and…”
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Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates by Fahey, Jed W., Stephenson, Katherine K., Wade, Kristina L., Talalay, Paul

“…•Sulforaphane, which is bactericidal to Helicobacter pylori, also inactivates its urease.•Kinetic and spectral evidence consistent with cysteine thiol covalent…”
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Induction of Phase 2 Genes by Sulforaphane Protects Retinal Pigment Epithelial Cells against Photooxidative Damage by Gao, Xiangqun, Talalay, Paul

“…The retinal pigment epithelial cell (RPE cell) layer protects the photoreceptors of the retina against oxidative stress. The decline of this capacity is…”
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Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency by Fahey, Jed W., Wade, Kristina L., Wehage, Scott L., Holtzclaw, Walter David, Liu, Hua, Talalay, Paul, Fuchs, Edward, Stephenson, Katherine K.

“…Scope The isothiocyanate sulforaphane (SF) from broccoli is one of the most potent known inducers of the cytoprotective phase 2 response. Its role in a host of…”
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Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice by Cho, Hye-Youn, Miller-DeGraff, Laura, Blankenship-Paris, Terry, Wang, Xuting, Bell, Douglas A., Lih, Fred, Deterding, Leesa, Panduri, Vijayalakshmi, Morgan, Daniel L., Yamamoto, Masayuki, Reddy, Anita J., Talalay, Paul, Kleeberger, Steven R.

“…Nrf2 is essential to antioxidant response element (ARE)-mediated host defense. Sulforaphane (SFN) is a phytochemical antioxidant known to affect multiple…”
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Biomarker-Guided Strategy for Treatment of Autism Spectrum Disorder (ASD) by Liu, Hua, Talalay, Paul, Fahey, Jed W

“…Autism spectrum disorder (ASD) is a complex, life-long neurodevelopmental disorder currently affecting an estimated 1 out of 68 among children aged 8 y in the…”
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Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora by Fahey, Jed W, Wehage, Scott L, Holtzclaw, W David, Kensler, Thomas W, Egner, Patricia A, Shapiro, Theresa A, Talalay, Paul

“…Plant-based diets rich in crucifers are effective in preventing cancer and other chronic diseases. Crucifers contain very high concentrations of glucosinolates…”
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Rapid and Sustainable Detoxication of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China by EGNER, Patricia A, CHEN, Jian-Guo, FAHEY, Jed W, TALALAY, Paul, JIAN ZHU, CHEN, Tao-Yang, QIAN, Geng-Sun, CARMELLA, Steven G, HECHT, Stephen S, KENSLER, Thomas W, ZARTH, Adam T, NG, Derek K, WANG, Jin-Bing, KENSLER, Kevin H, JACOBSON, Lisa P, MUNOZ, Alvaro, JOHNSON, Jamie L, GROOPMAN, John D

“…Broccoli sprouts are a convenient and rich source of the glucosinolate, glucoraphanin, which can generate the chemopreventive agent, sulforaphane, an inducer…”
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Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism by Talalay, P, Fahey, J W

“…Several epidemiologic studies suggest that consumption of cruciferous vegetables may be particularly effective (compared with total fruit and vegetable…”
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Electrophilic tuning of the chemoprotective natural product sulforaphane by Ahn, Young-Hoon, Hwang, Yousang, Liu, Hua, Wang, Xiu Jun, Zhang, Ying, Stephenson, Katherine K, Boronina, Tatiana N, Cole, Robert N, Dinkova-Kostova, Albena T, Talalay, Paul, Cole, Philip A

“…Sulforaphane [1-isothiocyanato-4-(methylsulfinyl)butane], a naturally occurring isothiocyanate derived from cruciferous vegetables, is a highly potent inducer…”
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Chemoprotection against cancer by induction of Phase 2 enzymes by Talalay, Paul

“…Induction of Phase 2 enzymes is an effective and sufficient strategy for achieving protection against the toxic and neoplastic effects of many carcinogens. It…”
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Direct Evidence That Sulfhydryl Groups of Keap1 Are the Sensors Regulating Induction of Phase 2 Enzymes That Protect against Carcinogens and Oxidants by Dinkova-Kostova, Albena T., Holtzclaw, W. David, Cole, Robert N., Itoh, Ken, Wakabayashi, Nobunao, Katoh, Yasutake, Yamamoto, Masayuki, Talalay, Paul

“…Coordinate induction of phase 2 proteins and elevation of glutathione protect cells against the toxic and carcinogenic effects of electrophiles and oxidants…”
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Reply to Scahill: Behavioral outcome measures in autism by Talalay, Paul, Zimmerman, Andrew W.

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Protection against Electrophile and Oxidant Stress by Induction of the Phase 2 Response: Fate of Cysteines of the Keap1 Sensor Modified by Inducers by Wakabayashi, Nobunao, Dinkova-Kostova, Albena T., Holtzclaw, W. David, Kang, Moon-Il, Kobayashi, Akira, Yamamoto, Masayuki, Kensler, Thomas W., Talalay, Paul

“…Induction of a family of phase 2 genes encoding for proteins that protect against the damage of electrophiles and reactive oxygen intermediates is potentially…”
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Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation by Talalay, Paul, Fahey, Jed W, Healy, Zachary R, Wehage, Scott L, Benedict, Andrea L, Min, Christine, Dinkova-Kostova, Albena T

“…UV radiation (UVR) is a complete carcinogen that elicits a constellation of pathological events, including direct DNA damage, generation of reactive oxidants…”
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