Search Results - "TALALAY, P"

Perspectives for development of ice drilling technology: continuation of the discussion by Talalay, P. G., Hong, J.

“…Recently, innovations in ice drilling have yielded considerable improvements to existing drilling techniques, as well as innovative drilling technologies that…”
Get full text

The SUBGLACIOR drilling probe: hydraulic considerations by Alemany, O., Talalay, P., Boissonneau, P., Chappellaz, J., Chemin, J. F., Duphil, R., Lefebvre, E., Piard, L., Possenti, P., Triest, J.

“…Using significant technological breakthroughs and unconventional approaches, the goal of the in situ probing of glacier ice for a better understanding of the…”
Get full text

Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism by Talalay, P, Fahey, J W

“…Several epidemiologic studies suggest that consumption of cruciferous vegetables may be particularly effective (compared with total fruit and vegetable…”
Get more information

Chemoprotection against cancer by induction of Phase 2 enzymes by Talalay, Paul

“…Induction of Phase 2 enzymes is an effective and sufficient strategy for achieving protection against the toxic and neoplastic effects of many carcinogens. It…”
Get full text

Antioxidant Functions of Sulforaphane: a Potent Inducer of Phase II Detoxication Enzymes by Fahey, J.W, Talalay, P

“…The widespread belief that oxidative damage plays a major role in cancer, ageing, and in a number of chronic diseases has focused scientific and public…”
Get full text

Quantification of skin erythema response to topical alcohol in alcohol-intolerant East Asians by Aoki, Y, Wehage, S L, Talalay, P

“…Severe alcohol intolerance characterized by flushing, headache, nausea, and tachycardia even after very modest oral alcohol consumption, is common among East…”
Get more information

The chemical diversity and distribution of glucosinolates and isothiocyanates among plants by FAHEY, Jed W, ZALCMANN, Amy T, TALALAY, Paul

“…Glucosinolates (beta-thioglucoside-N-hydroxysulfates), the precursors of isothiocyanates, are present in sixteen families of dicotyledonous angiosperms…”
Get full text

Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts : Metabolism and excretion in humans by SHAPIRO, Theresa A, FAHEY, Jed W, WADE, Kristina L, STEPHENSON, Katherine K, TALALAY, Paul

“…Broccoli sprouts are a rich source of glucosinolates and isothiocyanates that induce phase 2 detoxication enzymes, boost antioxidant status, and protect…”
Get full text

Powerful and Prolonged Protection of Human Retinal Pigment Epithelial Cells, Keratinocytes, and Mouse Leukemia Cells against Oxidative Damage: The Indirect Antioxidant Effects of Sulforaphane by Gao, Xiangqun, Dinkova-Kostova, Albena T., Talalay, Paul

“…Mammalian cells are equipped with elaborate systems for protection against the toxicity of reactive oxygen and nitrogen species and electrophiles that are…”
Get full text

Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables by Shapiro, T A, Fahey, J W, Wade, K L, Stephenson, K K, Talalay, P

“…Isothiocyanates and their naturally occurring glucosinolate precursors are widely consumed as part of a diet rich in cruciferous vegetables. When plant cells…”
Get full text

Electrophile and Antioxidant Regulation of Enzymes that Detoxify Carcinogens by Prestera, Tory, Talalay, Paul

“…Detoxication (phase 2) enzymes, such as glutathione S-transferases (GSTs), NAD(P)H:(quinone-acceptor) oxidoreductase (QR), and UDP-glucuronosyltransferase, are…”
Get full text

Isothiocyanates as substrates for human glutathione transferases: structure-activity studies by Kolm, R H, Danielson, U H, Zhang, Y, Talalay, P, Mannervik, B

“…The catalytic properties of four human glutathione transferases (GSTs), A1-1, M1-1, M4-4 and P1-1, were examined with 14 isothiocyanate (R-NCS) substrates. The…”
Get full text

The Three-Dimensional Structure of NAD(P)H:Quinone Reductase, a Flavoprotein Involved in Cancer Chemoprotection and Chemotherapy: Mechanism of the Two-Electron Reduction by Li, Rongbao, Bianchet, Mario A., Talalay, Paul, Amzel, L. Mario

“…Quinone reductase [NAD(P)H:(quinone acceptor) oxidoreductase, EC 1.6.99.2], also called DT diaphorase, is a homodimeric FAD-containing enzyme that catalyzes…”
Get full text

Chemical and Molecular Regulation of Enzymes that Detoxify Carcinogens by Prestera, Tory, Holtzclaw, W. David, Zhang, Yuesheng, Talalay, Paul

“…Inductions of detoxication (phase 2) enzymes, such as glutathione transferases and NAD(P)H:(quinoneacceptor) oxidoreductase, are a major mechanism for…”
Get full text

Phenolic Michael reaction acceptors: combined direct and indirect antioxidant defenses against electrophiles and oxidants by Dinkova-Kostova, A T, Cheah, J, Samouilov, A, Zweier, J L, Bozak, R E, Hicks, R J, Talalay, P

“…The implications of oxidative stress in the pathogenesis of many chronic human diseases has led to the widely accepted view that low molecular weight…”
Get more information

Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates by Zhang, Y.S, Kensler, T.W, Cho, C.G, Posner, G.H, Talalay, P

“…Sulforaphane [1-isothiocyanato-4-(methyl-sulfinyl) butane] was recently isolated from one variety of broccoli as the major add very potent inducer of phase 2…”
Get full text

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure by Zhang, Y. (The Johns Hopkins University School of Medicine, Baltimore, MD), Talalay, P, Cho, C.G, Posner, G.H

“…Consumption of vegetables, especially crucifers, reduces the risk of developing cancer. Although the mechanisms of this protection are unclear, feeding of…”
Get full text

Chemoprotection against cancer by isothiocyanates and glucosinolates by Talalay, P, Zhang, Y

Get more information

Removal of cuttings in deep ice electromechanical drills by Talalay, P.G.

“…The thorough removal of cuttings is one of the key requirements for successful drilling in ice. Otherwise cuttings can form packed ice rings above and near the…”
Get full text

Reversible Conjugation of Isothiocyanates with Glutathione Catalyzed by Human Glutathione Transferases by Zhang, Y.S., Kolm, R.H., Mannervik, B., Talalay, P.

“…Rates were determined for the nonenzymatic (second order rate constants) and enzyme-catalyzed conjugations with glutathione of four isothiocyanates that are…”
Get full text