Search Results - "TAKUWA, Yoh"

Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4 by Yasuda, Daisuke, Kobayashi, Daiki, Akahoshi, Noriyuki, Ohto-Nakanishi, Takayo, Yoshioka, Kazuaki, Takuwa, Yoh, Mizuno, Seiya, Takahashi, Satoru, Ishii, Satoshi

“…Lysophosphatidic acid (LPA) is a potent lipid mediator with various biological functions mediated through six G protein-coupled receptors (GPCRs), LPA1-6…”
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Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells by Shimizu, Shota, Yoshioka, Kazuaki, Aki, Sho, Takuwa, Yoh

“…The class II α-isoform of phosphatidylinositol 3-kinase (PI3K-C2α) plays a crucial role in angiogenesis at least in part through participating in endocytosis…”
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Sphingosine-1-phosphate signaling in physiology and diseases by Takuwa, Yoh, Okamoto, Yasuo, Yoshioka, Kazuaki, Takuwa, Noriko

“…Sphingosine‐1‐phosphate (S1P), which acts as both the extracellular and intracellular messenger, exerts pleiotropic biological activities including regulation…”
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Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice by Cui, Hong, MD, PhD, Okamoto, Yasuo, MD, PhD, Yoshioka, Kazuaki, PhD, Du, Wa, MD, PhD, Takuwa, Noriko, MD, PhD, Zhang, Wei, MD, PhD, Asano, Masahide, PhD, Shibamoto, Toshishige, MD, PhD, Takuwa, Yoh, MD, PhD

“…Background Sphingosine-1-phosphate receptor 2 (S1P2 ) is expressed in vascular endothelial cells (ECs). However, the role of S1P2 in vascular barrier integrity…”
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Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease by Lee, Ju Youn, Han, Seung Hoon, Park, Min Hee, Baek, Bosung, Song, Im-Sook, Choi, Min-Koo, Takuwa, Yoh, Ryu, Hoon, Kim, Seung Hyun, He, Xingxuan, Schuchman, Edward H., Bae, Jae-Sung, Jin, Hee Kyung

“…Although many reports have revealed the importance of defective microglia-mediated amyloid β phagocytosis in Alzheimer’s disease (AD), the underlying mechanism…”
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Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system by Takuwa, Yoh, Okamoto, Yasuo, Yoshioka, Kazuaki, Takuwa, Noriko

“…The plasma lysophospholipid mediator sphingosine-1-phosphate (S1P) is produced exclusively by sphingosine kinase (SPHK) 1 and SPHK2 in vivo, and plays diverse…”
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Sphingosine kinase 1 is involved in triglyceride breakdown by maintaining lysosomal integrity in brown adipocytes by Morishige, Jun-ichi, Yoshioka, Kazuaki, Nakata, Hiroki, Ishimaru, Kazuhiro, Nagata, Naoto, Tanaka, Tamotsu, Takuwa, Yoh, Ando, Hitoshi

“…Sphingosine 1-phosphate (S1P) has been implicated in brown adipose tissue (BAT) formation and energy consumption; however, the mechanistic role of…”
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Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6 by Ohkura, Sei-Ichiro, Usui, Soichiro, Takashima, Shin-Ichiro, Takuwa, Noriko, Yoshioka, Kazuaki, Okamoto, Yasuo, Inagaki, Yutaka, Sugimoto, Naotoshi, Kitano, Teppei, Takamura, Masayuki, Wada, Takashi, Kaneko, Shuichi, Takuwa, Yoh

“…Cardiac fibroblasts, together with cardiomyocytes, occupy the majority of cells in the myocardium and are involved in myocardial remodeling. The…”
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Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation by Ishimaru, Kazuhiro, Yoshioka, Kazuaki, Kano, Kuniyuki, Kurano, Makoto, Saigusa, Daisuke, Aoki, Junken, Yatomi, Yutaka, Takuwa, Noriko, Okamoto, Yasuo, Proia, Richard L., Takuwa, Yoh

“…Atherosclerosis is the major cause of ischemic coronary heart diseases and characterized by the infiltration of cholesterol-accumulating macrophages in the…”
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Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages by Zhao, Juanjuan, Okamoto, Yasuo, Asano, Yuya, Ishimaru, Kazuhiro, Aki, Sho, Yoshioka, Kazuaki, Takuwa, Noriko, Wada, Takashi, Inagaki, Yutaka, Takahashi, Chiaki, Nishiuchi, Takumi, Takuwa, Yoh

“…Idiopathic pulmonary fibrosis is a devastating disease with poor prognosis. The pathogenic role of the lysophospholipid mediator sphingosine-1-phosphate and…”
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Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet―Fed Mice by BRUCE, Clinton R, RISIS, Steve, MEIKLE, Peter J, PITSON, Stuart M, FEBBRAIO, Mark A, BABB, Joanne R, YANG, Christine, KOWALSKI, Greg M, SELATHURAI, Ahrathy, LEE-YOUNG, Robert S, WEIR, Jacquelyn M, YOSHIOKA, Kazuaki, TAKUWA, Yoh

“…The sphingolipids sphingosine-1-phosphate (S1P) and ceramide are important bioactive lipids with many cellular effects. Intracellular ceramide accumulation…”
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Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling by Serafimidis, Ioannis, Rodriguez-Aznar, Eva, Lesche, Mathias, Yoshioka, Kazuaki, Takuwa, Yoh, Dahl, Andreas, Pan, Duojia, Gavalas, Anthony

“…During development, progenitor expansion, lineage allocation, and implementation of differentiation programs need to be tightly coordinated so that different…”
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S1P2, the G Protein–Coupled Receptor for Sphingosine-1-Phosphate, Negatively Regulates Tumor Angiogenesis and Tumor Growth In vivo in Mice by Du, Wa, Takuwa, Noriko, Yoshioka, Kazuaki, Okamoto, Yasuo, Gonda, Koichi, Sugihara, Kazushi, Fukamizu, Akiyoshi, Asano, Masahide, Takuwa, Yoh

“…Sphingosine-1-phosphate (S1P) has been implicated in tumor angiogenesis by acting through the Gi-coupled chemotactic receptor S1P1. Here, we report that the…”
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Inhibitory and Stimulatory Regulation of Rac and Cell Motility by the G12/13-Rho and Gi Pathways Integrated Downstream of a Single G Protein-Coupled Sphingosine-1-Phosphate Receptor Isoform by Sugimoto, Naotoshi, Takuwa, Noriko, Okamoto, Hiroyuki, Sakurada, Sotaro, Takuwa, Yoh

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo by Funaki, Masaya, Kitabayashi, Juria, Shimakami, Tetsuro, Nagata, Naoto, Sakai, Yuriko, Takegoshi, Kai, Okada, Hikari, Murai, Kazuhisa, Shirasaki, Takayoshi, Oyama, Takeru, Yamashita, Taro, Ota, Tsuguhito, Takuwa, Yoh, Honda, Masao, Kaneko, Shuichi

“…Sphingosine-1-phospate is a potent bioactive lipid metabolite that regulates cancer progression. Because sphingosine kinase 1 and sphingosine kinase 2 (SPHK…”
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Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice by Islam, Shahidul, Yoshioka, Kazuaki, Aki, Sho, Ishimaru, Kazuhiro, Yamada, Hiroki, Takuwa, Noriko, Takuwa, Yoh

“…Class II phosphatidylinositol 3-kinases (PI3K), PI3K-C2α and PI3K-C2β, are involved in cellular processes including endocytosis, cilia formation and autophagy…”
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Sphigosine-1-phosphate receptor 1 promotes neointimal hyperplasia in a mouse model of carotid artery injury by Kitano, Teppei, Usui, Soichiro, Takashima, Shin-ichiro, Inoue, Oto, Goten, Chiaki, Nomura, Ayano, Yoshioka, Kazuaki, Okajima, Masaki, Kaneko, Shuichi, Takuwa, Yoh, Takamura, Masayuki

“…Vascular remodeling, resulting from proliferation and migration of vascular smooth muscle cells (VSMCs), is a major cause of atherosclerosis and restenosis…”
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Receptor for advanced glycation end products - membrane type1 matrix metalloproteinase axis regulates tissue factor expression via RhoA and Rac1 activation in high-mobility group box-1 stimulated endothelial cells by Sugimoto, Koichi, Ohkawara, Hiroshi, Nakamura, Yuichi, Takuwa, Yoh, Ishibashi, Toshiyuki, Takeishi, Yasuchika

“…Atherosclerosis is understood to be a blood vessel inflammation. High-mobility group box-1 (HMGB-1) plays a key role in the systemic inflammation. Tissue…”
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LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells by Sugimoto, Koichi, Ishibashi, Toshiyuki, Sawamura, Tatsuya, Inoue, Nobutaka, Kamioka, Masashi, Uekita, Hironori, Ohkawara, Hiroshi, Sakamoto, Takayuki, Sakamoto, Nobuo, Okamoto, Yasuo, Takuwa, Yoh, Kakino, Akemi, Fujita, Yoshiko, Tanaka, Takeshi, Teramoto, Tamio, Maruyama, Yukio, Takeishi, Yasuchika

“…Aims RhoA and Rac1 activation plays a key role in endothelial dysfunction. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a major receptor…”
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MTMR4, a phosphoinositide‐specific 3’‐phosphatase, regulates TFEB activity and the endocytic and autophagic pathways by Pham, Hoa Q., Yoshioka, Kazuaki, Mohri, Hiromi, Nakata, Hiroki, Aki, Sho, Ishimaru, Kazuhiro, Takuwa, Noriko, Takuwa, Yoh

“…Phosphatidylinositol 3‐phosphate (PI(3)P) is the predominant phosphoinositide species in early endosomes and autophagosomes, in which PI(3)P dictates traffic…”
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