Search Results - "TAKIGAHIRA, Misato"

NC‐6300, an epirubicin‐incorporating micelle, extends the antitumor effect and reduces the cardiotoxicity of epirubicin by Takahashi, Amane, Yamamoto, Yoshiyuki, Yasunaga, Masahiro, Koga, Yoshikatsu, Kuroda, Jun‐ichiro, Takigahira, Misato, Harada, Mitsunori, Saito, Hiroyuki, Hayashi, Tatsuyuki, Kato, Yasuki, Kinoshita, Taira, Ohkohchi, Nobuhiro, Hyodo, Ichinosuke, Matsumura, Yasuhiro

“…Epirubicin is widely used to treat various human tumors. However, it is difficult to achieve a sufficient antitumor effect because of dosage limitation to…”
Get full text

The Metastasis-Associated microRNA miR-516a-3p Is a Novel Therapeutic Target for Inhibiting Peritoneal Dissemination of Human Scirrhous Gastric Cancer by TAKEI, Yoshifumi, TAKIGAHIRA, Misato, MIHARA, Keichiro, TARUMI, Yuzo, YANAGIHARA, Kazuyoshi

“…Although aberrant microRNA (miRNA) is expressed in different types of human cancer tissues, its pathophysiologic role and the relevance of tumorigenesis and…”
Get full text

CUB-Domain-Containing Protein 1 Regulates Peritoneal Dissemination of Gastric Scirrhous Carcinoma by Uekita, Takamasa, Tanaka, Masamitsu, Takigahira, Misato, Miyazawa, Yuri, Nakanishi, Yukihiro, Kanai, Yae, Yanagihara, Kazuyoshi, Sakai, Ryuichi

“…CUB-domain-containing protein 1 (CDCP1) is a type-I transmembrane protein that is highly expressed in colon, breast, and lung cancers. We recently revealed…”
Get full text

Inhibitory Effects of Isoflavones on Tumor Growth and Cachexia in Newly Established Cachectic Mouse Models Carrying Human Stomach Cancers by Yanagihara, Kazuyoshi, Takigahira, Misato, Mihara, Keichiro, Kubo, Takanori, Morimoto, Chie, Morita, Yasuhiro, Terawaki, Kiyoshi, Uezono, Yasuhito, Seyama, Toshio

“…Cachexia, a negative prognostic factor, worsens a patient's quality of life. We established 2 novel cachexia models with the human stomach cancer cell line…”
Get full text

Intraperitoneal delivery of a small interfering RNA targeting NEDD1 prolongs the survival of scirrhous gastric cancer model mice by Fujita, Takeshi, Yanagihara, Kazuyoshi, Takeshita, Fumitaka, Aoyagi, Kazuhiko, Nishimura, Takao, Takigahira, Misato, Chiwaki, Fumiko, Fukagawa, Takeo, Katai, Hitoshi, Ochiya, Takahiro, Sakamoto, Hiromi, Konno, Hiroyuki, Yoshida, Teruhiko, Sasaki, Hiroki

“…The prognosis of patients with advanced diffuse‐type gastric cancer (GC), especially scirrhous gastric cancer (SGC) remains extremely poor. Peritoneal…”
Get full text

Development and biological analysis of peritoneal metastasis mouse models for human scirrhous stomach cancer by Yanagihara, Kazuyoshi, Takigahira, Misato, Tanaka, Hiromi, Komatsu, Teruo, Fukumoto, Hisao, Koizumi, Fumiaki, Nishio, Kazuto, Ochiya, Takahiro, Ino, Yoshinori, Hirohashi, Setsuo

“…The number of published studies on peritoneal dissemination of scirrhous gastric carcinoma is very small as a result of the unavailability of highly…”
Get full text

A photon counting technique for quantitatively evaluating progression of peritoneal tumor dissemination by YANAGIHARA, Kazuyoshi, TAKIGAHIRA, Misato, TAKESHITA, Fumitaka, KOMATSU, Teruo, NISHIO, Kazuto, HASEGAWA, Fumio, OCHIYA, Takahiro

“…We recently established a mouse model of peritoneal dissemination of human gastric carcinoma, including the formation of ascites, by orthotopic transplantation…”
Get full text

Establishment of two cell lines from human gastric scirrhous carcinoma that possess the potential to metastasize spontaneously in nude mice by Yanagihara, Kazuyoshi, Tanaka, Hiromi, Takigahira, Misato, Ino, Yoshinori, Yamaguchi, Yoshiyuki, Toge, Tetsuya, Sugano, Kokichi, Hirohashi, Setsuo

“…Few experimental studies have been conducted to clarify the mechanism of development of metastasis in scirrhous carcinoma of the stomach. In the present study,…”
Get full text

Phosphorylation of Ephrin-B1 Regulates Dissemination of Gastric Scirrhous Carcinoma by Tanaka, Masamitsu, Kamata, Reiko, Takigahira, Misato, Yanagihara, Kazuyoshi, Sakai, Ryuichi

“…Interaction of the Eph family of receptor protein tyrosine kinase and its ligand ephrin family induces bidirectional signaling via cell-cell contacts. High…”
Get full text

Establishment and molecular profiling of a novel human pancreatic cancer panel for 5‐FU by Yanagihara, Kazuyoshi, Takigahira, Misato, Tanaka, Hiromi, Arao, Tokuzo, Aoyagi, Yasuyuki, Oda, Tatsuya, Ochiai, Atsushi, Nishio, Kazuto

“…Ten novel human pancreatic carcinoma cell lines (Sui65 through Sui74) were established from a transplantable pancreatic carcinoma cell line. All the cell lines…”
Get full text

Marked antitumor effect of NK012, a SN-38-incorporating micelle formulation, in a newly developed mouse model of liver metastasis resulting from gastric cancer by Yanagihara, Kazuyoshi, Takigahira, Misato, Kubo, Takanori, Ochiya, Takahiro, Hamaguchi, Tetsuya, Matsumura, Yasuhiro

“…Gastric cancer with liver metastasis (LM) is associated with poor prognosis due to rapid progression. It is, therefore, important to develop a quantitative and…”
Get more information

ZD6474 inhibits tumor growth and intraperitoneal dissemination in a highly metastatic orthotopic gastric cancer model by Arao, Tokuzo, Yanagihara, Kazuyoshi, Takigahira, Misato, Takeda, Masayuki, Koizumi, Fumiaki, Shiratori, Yasushi, Nishio, Kazuto

“…Angiogenesis inhibitors have been used to treat some cancers, but the therapeutic potential of these agents for gastric cancer has remained unclear. To…”
Get full text

Effect of combined treatment with the epirubicin‐incorporating micelles (NC‐6300) and 1,2‐diaminocyclohexane platinum (II)‐incorporating micelles (NC‐4016) on a human gastric cancer model by Yamamoto, Yoshiyuki, Hyodo, Ichinosuke, Takigahira, Misato, Koga, Yoshikatsu, Yasunaga, Masahiro, Harada, Mitsunori, Hayashi, Tatsuyuki, Kato, Yasuki, Matsumura, Yasuhiro

“…Anticancer agent‐incorporating polymeric micelles accumulate effectively in tumors via the enhanced permeability and retention effect to exert potent antitumor…”
Get full text

The significance of microscopic mass spectrometry with high resolution in the visualisation of drug distribution by Yasunaga, Masahiro, Furuta, Masaru, Ogata, Koretsugu, Koga, Yoshikatsu, Yamamoto, Yoshiyuki, Takigahira, Misato, Matsumura, Yasuhiro

“…The visualisation and quantitative analysis of the native drug distribution in a pre-clinical or clinical setting are desirable for evaluating drug effects and…”
Get full text

Synergistic and persistent effect of T‐cell immunotherapy with anti‐CD19 or anti‐CD38 chimeric receptor in conjunction with rituximab on B‐cell non‐Hodgkin lymphoma by Mihara, Keichiro, Yanagihara, Kazuyoshi, Takigahira, Misato, Kitanaka, Akira, Imai, Chihaya, Bhattacharyya, Joyeeta, Kubo, Takanori, Takei, Yoshifumi, Yasunaga, Shin’ichiro, Takihara, Yoshihiro, Kimura, Akiro

“…Summary Using artificial receptors, it is possible to redirect the specificity of immune cells to tumour‐associated antigens, which is expected to provide a…”
Get full text

Tumor Environment Changed by Combretastatin Derivative (Cderiv) Pretreatment That Leads to Effective Tumor Targeting, MRI Studies, and Antitumor Activity of Polymeric Micelle Carrier Systems by Shiraishi, Kouichi, Harada, Yoshiko, Kawano, Kumi, Maitani, Yoshie, Hori, Katsuyoshi, Yanagihara, Kazuyoshi, Takigahira, Misato, Yokoyama, Masayuki

“…ABSTRACT Purpose To evaluate effect of a vascular disrupting agent, a combretastatin derivative (Cderiv), on tumor targeting for polymeric micelle carrier…”
Get full text

Antitumor effect of SN-38-releasing polymeric micelles, NK012, on spontaneous peritoneal metastases from orthotopic gastric cancer in mice compared with irinotecan by Nakajima, Takako Eguchi, Yanagihara, Kazuyoshi, Takigahira, Misato, Yasunaga, Masahiro, Kato, Ken, Hamaguchi, Tetsuya, Yamada, Yasuhide, Shimada, Yasuhiro, Mihara, Keichiro, Ochiya, Takahiro, Matsumura, Yasuhiro

“…7-Ethyl-10-hydroxy-camptothecin (SN-38), an active metabolite of irinotecan hydrochloride (CPT-11), has potent antitumor activity. Moreover, we have reported…”
Get full text

An orthotopic implantation mouse model of human malignant pleural mesothelioma for in vivo photon counting analysis and evaluation of the effect of S‐1 therapy by Yanagihara, Kazuyoshi, Tsumuraya, Masaru, Takigahira, Misato, Mihara, Keichiro, Kubo, Takanori, Ohuchi, Kazuo, Seyama, Toshio

“…Human malignant pleural mesothelioma (HMPM) is an aggressive neoplasm that is highly resistant to conventional therapies. We established 3 HMPM cell lines…”
Get full text

Activated T-cell-mediated Immunotherapy With a Chimeric Receptor Against CD38 in B-cell Non-Hodgkin Lymphoma by MIHARA, Keichiro, YANAGIHARA, Kazuyoshi, TAKIGAHIRA, Misato, IMAI, Chihaya, KITANAKA, Akira, TAKIHARA, Yoshihiro, KIMURA, Akiro

“…T-cell-mediated immunotherapy with a chimeric antigen receptor (CAR) is expected to become a powerful treatment for cancer. CD38, highly expressed in B-cell…”
Get full text

Abstract 4525: Combined antitumor activity of the epirubicin-incorporating polymeric micelle NC-6300 and the DACHPt-incorporating polymeric micelle NC-4016 in mice bearing human gastric cancer xenografts by Yamamoto, Yoshiyuki, Hyodo, Ichinosuke, Takigahira, Misato, Koga, Yoshikatsu, Yasunaga, Masahiro, Harada, Mitsunori, Hayashi, Tatsuyuki, Kato, Yasuki, Matsumura, Yasuhiro

“…Background: Several anticancer agent (ACA)-incorporating polymeric micelles are known to accumulate effectively in tumors and exert sufficient antitumor…”
Get full text