Search Results - "TAKEYA, MOTOHIRO"

Clinical significance of macrophage heterogeneity in human malignant tumors by Komohara, Yoshihiro, Jinushi, Masahisa, Takeya, Motohiro

“…The fact that various immune cells, including macrophages, can be found in tumor tissue has long been known. With the recent introduction of the novel concept…”
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Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy by Komohara, Yoshihiro, Fujiwara, Yukio, Ohnishi, Koji, Takeya, Motohiro

“…The macrophage is known to be a multifunctional antigen presenting cells and playing a central role in inflammation. Macrophages infiltrate into malignant…”
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Role of tumor-associated macrophages in human malignancies: friend or foe? by Takeya, Motohiro, Komohara, Yoshihiro

“…Tumor‐associated macrophages (TAMs) play a pivotal role in tumor growth in human malignancies. Published studies have analyzed the relationship between TAM…”
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Possible functions of CD169‐positive sinus macrophages in lymph nodes in anti‐tumor immune responses by Komohara, Yoshihiro, Ohnishi, Koji, Takeya, Motohiro

“…The lymph node (LN) is an important immune system in which a number of antigen‐presenting cells are present that induce rapid immune responses to foreign…”
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Macrophage infiltration and its prognostic relevance in clear cell renal cell carcinoma by Komohara, Yoshihiro, Hasita, Horlad, Ohnishi, Koji, Fujiwara, Yukio, Suzu, Shinya, Eto, Masatoshi, Takeya, Motohiro

“…Most malignant tumors evidence infiltration of many macrophages. In this study, we investigated an anti‐inflammatory macrophage phenotype (M2) in clear cell…”
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Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription‐3 and nuclear factor‐kappa B in tumor cells and tumor‐associated macrophages by Fujiwara, Yukio, Komohara, Yoshihiro, Ikeda, Tsuyoshi, Takeya, Motohiro

“…Tumor‐associated macrophages (TAM) of M2 phenotype promote tumor proliferation and are associated with a poor prognosis in patients with glioblastoma. We…”
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CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma by Shiraishi, Daisuke, Fujiwara, Yukio, Horlad, Hasita, Saito, Yoichi, Iriki, Toyohisa, Tsuboki, Junko, Cheng, Pan, Nakagata, Naomi, Mizuta, Hiroshi, Bekki, Hirofumi, Nakashima, Yasuharu, Oda, Yoshinao, Takeya, Motohiro, Komohara, Yoshihiro

“…Recent findings have shown the significance of CD163-positive macrophages in tumor progression, yet there have been few studies on the function of CD163 in…”
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An IL‐27/Stat3 axis induces expression of programmed cell death 1 ligands (PD‐L1/2) on infiltrating macrophages in lymphoma by Horlad, Hasita, Ma, Chaoya, Yano, Hiromu, Pan, Cheng, Ohnishi, Koji, Fujiwara, Yukio, Endo, Shinya, Kikukawa, Yoshitaka, Okuno, Yutaka, Matsuoka, Masao, Takeya, Motohiro, Komohara, Yoshihiro

“…Immune escape and tolerance in the tumor microenvironment are closely involved in tumor progression, and are caused by T‐cell exhaustion and mediated by the…”
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Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors by Kawamura, Kyoko, Komohara, Yoshihiro, Takaishi, Kiyomi, Katabuchi, Hidetaka, Takeya, Motohiro

“…Tumor‐associated macrophages (TAM) are known to possess the immunosuppressive M2 macrophage phenotype. They contribute to tumor growth, invasion, and…”
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Contribution of Macrophage Polarization to Metabolic Diseases by Komohara, Yoshihiro, Fujiwara, Yukio, Ohnishi, Koji, Shiraishi, Daisuke, Takeya, Motohiro

“…Macrophage activation is one of the major immunological events in the pathogenesis of various diseases. Recent studies have disclosed that complicated…”
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Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma by Hasita, Horlad, Komohara, Yoshihiro, Okabe, Hirohisa, Masuda, Toshiro, Ohnishi, Koji, Lei, Xiao F., Beppu, Toru, Baba, Hideo, Takeya, Motohiro

“…Many studies have shown that tumor‐associated macrophages (TAMs) contribute to tumor development and poor prognosis in various cancers. In this study, we…”
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CD169‐positive macrophages in regional lymph nodes are associated with a favorable prognosis in patients with colorectal carcinoma by Ohnishi, Koji, Komohara, Yoshihiro, Saito, Yoichi, Miyamoto, Yuji, Watanabe, Masayuki, Baba, Hideo, Takeya, Motohiro

“…CD169 (sialoadhesin) is a sialic acid receptor that is expressed on specific macrophages such as lymph node sinus macrophages. Animal studies have suggested…”
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High density of CD204‐positive macrophages predicts worse clinical prognosis in patients with breast cancer by Miyasato, Yuko, Shiota, Takuya, Ohnishi, Koji, Pan, Cheng, Yano, Hiromu, Horlad, Hasita, Yamamoto, Yutaka, Yamamoto‐Ibusuki, Mutsuko, Iwase, Hirotaka, Takeya, Motohiro, Komohara, Yoshihiro

“…Recent studies have indicated the clinical significance of tumor‐associated macrophages (TAM) in several malignant tumors including breast cancer. Although…”
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Role of tumor-associated macrophages in hematological malignancies by Komohara, Yoshihiro, Niino, Daisuke, Ohnishi, Koji, Ohshima, Koichi, Takeya, Motohiro

“…The tumor microenvironment consists of many non‐tumor cells such as leukocytes, endothelial cells, and fibroblasts, and phenotypic changes in a tumor…”
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Hepatic crown-like structure: a unique histological feature in non-alcoholic steatohepatitis in mice and humans by Itoh, Michiko, Kato, Hideaki, Suganami, Takayoshi, Konuma, Kuniha, Marumoto, Yoshio, Terai, Shuji, Sakugawa, Hiroshi, Kanai, Sayaka, Hamaguchi, Miho, Fukaishi, Takahiro, Aoe, Seiichiro, Akiyoshi, Kazunari, Komohara, Yoshihiro, Takeya, Motohiro, Sakaida, Isao, Ogawa, Yoshihiro

“…Although macrophages are thought to be crucial for the pathogenesis of chronic inflammatory diseases, how they are involved in disease progression from simple…”
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Clinical significance of CD163+ tumor‐associated macrophages in patients with adult T‐cell leukemia/lymphoma by Komohara, Yoshihiro, Niino, Daisuke, Saito, Yoichi, Ohnishi, Koji, Horlad, Hasita, Ohshima, Koichi, Takeya, Motohiro

“…In several malignant tumors including lymphoma, macrophages that infiltrate tumor tissues are called tumor‐associated macrophages (TAMs). We discovered that…”
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Importance of direct macrophage ‐ Tumor cell interaction on progression of human glioma by Komohara, Yoshihiro, Horlad, Hasita, Ohnishi, Koji, Fujiwara, Yukio, Bai, Bing, Nakagawa, Takenobu, Suzu, Shinya, Nakamura, Hideo, Kuratsu, Jun‐ichi, Takeya, Motohiro

“…We previously showed tumor‐associated macrophages/microglia (TAMs) polarized to the M2 phenotype were significantly involved in tumor cell proliferation and…”
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The Clinical Significance of CD169-Positive Lymph Node Macrophage in Patients with Breast Cancer by Shiota, Takuya, Miyasato, Yuko, Ohnishi, Koji, Yamamoto-Ibusuki, Mutsuko, Yamamoto, Yutaka, Iwase, Hirotaka, Takeya, Motohiro, Komohara, Yoshihiro

“…The immune status of patients can impact on the clinical course of cancer. Lymph node (LN) macrophages play critical roles in anti-cancer immunity via the…”
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Prognostic significance of CD169‐positive lymph node sinus macrophages in patients with endometrial carcinoma by Ohnishi, Koji, Yamaguchi, Munekage, Erdenebaatar, Chimeddulam, Saito, Fumitaka, Tashiro, Hironori, Katabuchi, Hidetaka, Takeya, Motohiro, Komohara, Yoshihiro

“…Lymph node (LN) macrophages play critical roles in anti‐tumor immunity, which develops via the activation of cytotoxic T cells (CTL) and NK cells. The present…”
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Overexpression of CD163, CD204 and CD206 on alveolar macrophages in the lungs of patients with severe chronic obstructive pulmonary disease by Kaku, Yoichiro, Imaoka, Haruki, Morimatsu, Yoshitaka, Komohara, Yoshihiro, Ohnishi, Koji, Oda, Hanako, Takenaka, Shinichi, Matsuoka, Masanobu, Kawayama, Tomotaka, Takeya, Motohiro, Hoshino, Tomoaki

“…We have previously reported that the lungs of patients with very severe chronic obstructive pulmonary disease (COPD) contain significantly higher numbers of…”
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