Search Results - "TAKENOUCHI, Takato"

An immortalized porcine macrophage cell line competent for the isolation of African swine fever virus by Masujin, Kentaro, Kitamura, Tomoya, Kameyama, Ken -ichiro, Okadera, Kota, Nishi, Tatsuya, Takenouchi, Takato, Kitani, Hiroshi, Kokuho, Takehiro

“…African swine fever virus (ASFV) is the etiological agent of African swine fever (ASF), a fatal hemorrhagic disease of domestic pigs and wild boar. The virus…”
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Stress-induced microglial activation occurs through β-adrenergic receptor: noradrenaline as a key neurotransmitter in microglial activation by Sugama, Shuei, Takenouchi, Takato, Hashimoto, Makoto, Ohata, Hisayuki, Takenaka, Yasuhiro, Kakinuma, Yoshihiko

“…The involvement of microglia in neuroinflammatory responses has been extensively demonstrated. Recent animal studies have shown that exposure to either acute…”
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Chronic restraint stress triggers dopaminergic and noradrenergic neurodegeneration: Possible role of chronic stress in the onset of Parkinson’s disease by Sugama, Shuei, Sekiyama, Kazunari, Kodama, Tohru, Takamatsu, Yoshiki, Takenouchi, Takato, Hashimoto, Makoto, Bruno, Conti, Kakinuma, Yoshihiko

“…Highlights • The present study investigated the effects of chronic stress on dopaminergic neurodegeneration. • The chronic stress significantly triggered the…”
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Establishment and characterization of an immortalized red river hog blood-derived macrophage cell line by Takenouchi, Takato, Masujin, Kentaro, Ikeda, Rina, Haraguchi, Seiki, Suzuki, Shunichi, Uenishi, Hirohide, Onda, Eiji, Kokuho, Takehiro

“…Red river hogs (RRHs) ( ), a wild species of living in Africa with a major distribution in the Guinean and Congolian forests, are natural reservoirs of African…”
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Dexamethasone enhances CD163 expression in porcine IPKM immortalized macrophages by Takenouchi, Takato, Morozumi, Takeya, Wada, Emi, Suzuki, Shunichi, Nishiyama, Yasutaka, Sukegawa, Shin, Uenishi, Hirohide

“…In our previous study, we established a unique porcine macrophage cell line, immortalized porcine kidney-derived macrophages (IPKM). The purpose of the present…”
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Possible Role of Activin in the Adiponectin Paradox-Induced Progress of Alzheimer's Disease by Hashimoto, Makoto, Ho, Gilbert, Sugama, Shuei, Takenouchi, Takato, Waragai, Masaaki, Sugino, Hiromu, Inoue, Satoshi, Masliah, Eliezer

“…Accumulating evidence suggests that the adiponectin (APN) paradox might be involved in promoting aging-associated chronic diseases such as Alzheimer's disease…”
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Ligilactobacillus salivarius Strains Isolated From the Porcine Gut Modulate Innate Immune Responses in Epithelial Cells and Improve Protection Against Intestinal Viral-Bacterial Superinfection by Indo, Yuhki, Kitahara, Shugo, Tomokiyo, Mikado, Araki, Shota, Islam, Md Aminul, Zhou, Binghui, Albarracin, Leonardo, Miyazaki, Ayako, Ikeda-Ohtsubo, Wakako, Nochi, Tomonori, Takenouchi, Takato, Uenishi, Hirohide, Aso, Hisashi, Takahashi, Hideki, Kurata, Shoichiro, Villena, Julio, Kitazawa, Haruki

“…Previously, we constructed a library of strains from the intestine of wakame-fed pigs and reported a strain-dependent capacity to modulate IFN-β expression in…”
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Adiponectin Paradox in Alzheimer's Disease; Relevance to Amyloidogenic Evolvability? by Waragai, Masaaki, Ho, Gilbert, Takamatsu, Yoshiki, Wada, Ryoko, Sugama, Shuei, Takenouchi, Takato, Masliah, Eliezer, Hashimoto, Makoto

“…Adiponectin (APN) is a multi-functional adipokine which sensitizes the insulin signals, stimulates mitochondria biogenesis, and suppresses inflammation. By…”
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A specific promoter-type in ribonuclease L gene is associated with phagocytic activity in pigs by SHINKAI, Hiroki, TAKAHAGI, Yoichi, MATSUMOTO, Toshimi, TOKI, Daisuke, TAKENOUCHI, Takato, KITANI, Hiroshi, SUKEGAWA, Shin, SUZUKI, Keiichi, UENISHI, Hirohide

“…We have previously generated Large White pigs with high immune competence using a selection strategy based on phagocytic activity (PA), capacity of alternative…”
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Synergistic induction of drug-metabolizing enzymes in co-cultures of bovine hepatocytic and sinusoidal cell lines by Yoshioka, Miyako, Takenouchi, Takato, Kitani, Hiroshi, Guruge, Keerthi S., Yamanaka, Noriko

“…Hepatocyte-derived cell lines provide useful experimental systems for studying liver metabolism. Unlike human and rodents, few hepatocyte-derived cell lines…”
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Establishment and characterization of the immortalized porcine lung-derived mononuclear phagocyte cell line by Takenouchi, Takato, Masujin, Kentaro, Suzuki, Shunichi, Haraguchi, Seiki, Hiramatsu, Kanae, Kokuho, Takehiro, Uenishi, Hirohide

“…Mononuclear phagocytes (MNP), including monocytes, dendritic cells (DC), and macrophages, play critical roles in innate immunity. MNP are abundant in the lungs…”
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The Activation of P2X7 Receptor Impairs Lysosomal Functions and Stimulates the Release of Autophagolysosomes in Microglial Cells by Takenouchi, Takato, Nakai, Masaaki, Iwamaru, Yoshifumi, Sugama, Shuei, Tsukimoto, Mitsutoshi, Fujita, Masayo, Wei, Jianshe, Sekigawa, Akio, Sato, Mitsuru, Kojima, Shuji, Kitani, Hiroshi, Hashimoto, Makoto

“…Recently, autophagy has been associated with the TLR signaling pathway to eliminate intracellular pathogens in the innate immune system. However, it is unknown…”
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Isolation and immortalization of macrophages derived from fetal porcine small intestine and their susceptibility to porcine viral pathogen infections by Takenouchi, Takato, Masujin, Kentaro, Miyazaki, Ayako, Suzuki, Shunichi, Takagi, Michihiro, Kokuho, Takehiro, Uenishi, Hirohide

“…Macrophages are a heterogeneous population of cells that are present in all vertebrate tissues. They play a key role in the innate immune system, and thus, in…”
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Polymorphisms in Pattern Recognition Receptor Genes Are Associated with Respiratory Disease Severity in Pig Farms by Suzuki, Kasumi, Shinkai, Hiroki, Yoshioka, Gou, Matsumoto, Toshimi, Takenouchi, Takato, Tanaka, Junji, Shimizu, Masanori, Kitazawa, Haruki, Uenishi, Hirohide

“…Reduced productivity caused by infections, particularly respiratory diseases, is a serious problem in pig farming. We have previously reported polymorphisms in…”
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Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia by Yanagitai, Mika, Itoh, Sayaka, Kitagawa, Tomomi, Takenouchi, Takato, Kitani, Hiroshi, Satoh, Takumi

“…► Carnosic acid inhibited LPS-induced inflammation of microglial MG6 cells. ► CA induced phase 2 enzymes both in the absence and presence of LPS. ► Phase 2…”
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Connecting Alzheimer’s Disease With Diabetes Mellitus Through Amyloidogenic Evolvability by Ho, Gilbert, Takamatsu, Yoshiki, Wada, Ryoko, Sugama, Shuei, Waragai, Masaaki, Takenouchi, Takato, Masliah, Eliezer, Hashimoto, Makoto

“…Type 2 diabetes mellitus (T2DM) has been clearly linked to oxidative stress and amylin amyloidosis in pancreatic β-cells. Yet, despite extensive investigation,…”
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Feasibility study of B16 melanoma therapy using oxidized ATP to target purinergic receptor P2X7 by Hattori, Fumie, Ohshima, Yasuhiro, Seki, Shizuka, Tsukimoto, Mitsutoshi, Sato, Mitsuru, Takenouchi, Takato, Suzuki, Akina, Takai, Erina, Kitani, Hiroshi, Harada, Hitoshi, Kojima, Shuji

“…The P2X7 receptor is not only involved in cell proliferation, but also acts as an adenosine 5′-triphosphate (ATP)-gated non-selective channel, and its…”
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Critical roles of the WASP N-terminal domain and Btk in LPS-induced inflammatory response in macrophages by Sakuma, Chisato, Sato, Mitsuru, Takenouchi, Takato, Chiba, Joe, Kitani, Hiroshi

“…While Wiskott-Aldrich syndrome protein (WASP) plays critical roles in TCR signaling as an adaptor molecule, how it transduces innate immune signals remains to…”
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P2X7 Receptor Signaling Pathway as a Therapeutic Target for Neurodegenerative Diseases by Takenouchi, Takato, Sekiyama, Kazunari, Sekigawa, Akio, Fujita, Masayo, Waragai, Masaaki, Sugama, Shuei, Iwamaru, Yoshifumi, Kitani, Hiroshi, Hashimoto, Makoto

“…A recent study suggested that neuroinflammation plays a major role in the pathogenesis of a number of neurodegenerative diseases such as Alzheimer’s disease…”
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Purinergic signaling via P2Y receptors up-mediates IL-6 production by liver macrophages/Kupffer cells by Ishimaru, Makiko, Yusuke, Negishi, Tsukimoto, Mitsutoshi, Harada, Hitoshi, Takenouchi, Takato, Kitani, Hiroshi, Kojima, Shuji

“…Resident macrophages in the liver (Kupffer cells) produce various cytokines and chemokines, and have important roles in hepatitis and liver fibrosis. The cells…”
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