POEMS syndrome complicated by follicular lymphoma

A 59-year-old woman presented with ascites and intraperitoneal lymph node swelling. Pathological examination of the lymph node revealed follicular lymphoma. After a lymph node biopsy, she developed atypical genital bleeding, multiple endocrine disorders, polyneuropathy with a high plasma level of va...

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Bibliographic Details
Published in:	Rinshō ketsueki Vol. 50; no. 11; p. 1621
Main Authors:	SASAKI, Takahide, OHNISHI, Shunsuke, ONISHI, Reizo, TAKEMURA, Ryou, KOBAYASHI, Yoshimitsu, SUZUKI, Mio, DAZAI, Masayoshi, HATA, Tamotsu, YAMAMOTO, Junji, ODA, Hisashi, TAKAHASHI, Tatsuro, OGASAWARA, Kazuhiro, MIYAGISHIMA, Takuto
Format:	Journal Article
Language:	English
Published:	Japan 01-11-2009
Subjects:	Biomarkers - blood Biopsy Fatal Outcome Female Humans Lymph Nodes - pathology Lymphoma, Follicular - complications Lymphoma, Follicular - diagnosis Lymphoma, Follicular - pathology Middle Aged POEMS Syndrome - complications POEMS Syndrome - diagnosis POEMS Syndrome - drug therapy POEMS Syndrome - pathology Prednisolone - administration & dosage Vascular Endothelial Growth Factor A - blood
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Summary:	A 59-year-old woman presented with ascites and intraperitoneal lymph node swelling. Pathological examination of the lymph node revealed follicular lymphoma. After a lymph node biopsy, she developed atypical genital bleeding, multiple endocrine disorders, polyneuropathy with a high plasma level of vascular endothelial growth factor (VEGF), and was diagnosed with POEMS syndrome. Following administration of methyl prednisolone, ascites immediately decreased and her performance status improved; however, about 18 months later, renal failure occurred, and she died despite increased steroid dosage. Lymph node swelling is often found in POEMS syndrome; however, its histological appearance is not well known, and it is very rare to be concomitant with malignant lymphoma. Therefore, it is important to perform a lymph node biopsy and investigate it in relation with VEGF.
ISSN:	0485-1439