Search Results - "TAKEI, Yoshinori"

Age-dependent decline in neurogenesis of the hippocampus and extracellular nucleotides by Takei, Yoshinori

“…New neurons are continuously generated in the adult brain. This generation primarily occurs in the subventricular zone (SVZ) of the lateral ventricles and the…”
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Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve by Amagase, Yoko, Kambayashi, Ryuichi, Sugiyama, Atsushi, Takei, Yoshinori

“…The brain-derived neurotrophic factor (BDNF) is an extensively studied neurotrophin es sential for both developing the brain and maintaining adult brain…”
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Soft x-ray nanobeam formed by an ellipsoidal mirror by Takeo, Yoko, Suzuki, Akihiro, Motoyama, Hiroto, Takei, Yoshinori, Kume, Takehiro, Matsuzawa, Yusuke, Senba, Yasunori, Kishimoto, Hikaru, Ohashi, Haruhiko, Mimura, Hidekazu

“…Ellipsoidal mirrors are promising optical devices for soft x-ray focusing. A fabrication process consisting of master fabrication and replication has been…”
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Highly efficient capture of cancer cells expressing EGFR by microfluidic methods based on antigen-antibody association by Ohnaga, Takashi, Takei, Yoshinori, Nagata, Takuya, Shimada, Yutaka

“…Epidermal growth factor receptor (EGFR) was evaluated as a target antigen for cancer cell capture by microfluidic methods based on antigen-antibody…”
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Uncertainty evaluation of the static expansion system and its long-term stability at NMIJ by Takei, Yoshinori, Yoshida, Hajime, Komatsu, Eiichi, Arai, Kenta

“…A pressure standard based on the static expansion of gases has been made available at the National Metrology Institute of Japan (NMIJ) for gauge calibrations…”
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Characterization of electropharmacological profile of an anti-atrial fibrillatory drug vernakalant along with potential risk toward torsade de pointes: Translational studies using isoflurane-anesthetized dogs and isolated rat aortic preparations by Goto, Ai, Kambayashi, Ryuichi, Izumi-Nakaseko, Hiroko, Shinozaki, Makoto, Takei, Yoshinori, Sugiyama, Atsushi

“…We simultaneously assessed electropharmacological effects of anti-atrial fibrillatory drug vernakalant and its potential risk toward torsade de pointes…”
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Characterization of cardiovascular profile of anti-influenza drug peramivir: A reverse-translational study using the isoflurane-anesthetized dog by Kambayashi, Ryuichi, Goto, Ai, Izumi-Nakaseko, Hiroko, Takei, Yoshinori, Sugiyama, Atsushi

“…An injectable anti-influenza drug peramivir has been reported to induce QT-interval prolongation in some phase III studies, although its thorough QT/QTc study…”
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Impact of head-up tilt on expiratory negative airway pressure ventilation-induced cardiovascular hemodynamics in the halothane-anesthetized intact microminipigs by Goto, Ai, Kambayashi, Ryuichi, Hagiwara-Nagasawa, Mihoko, Izumi-Nakaseko, Hiroko, Takei, Yoshinori, Kawai, Shinichi, Matsumoto, Akio, Lurie, Keith G., Sugiyama, Atsushi

“…Elevation of the head and expiratory negative airway pressure (ENAP) ventilation can both significantly alter cardiovascular hemodynamics. The impact of…”
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Appraisal of ICH E14/S7B Q&As adopted in February 2022 using thorough QT/QTc study data for α4-integrin antagonist carotegrast methyl in Japanese healthy subjects by Kambayashi, Ryuichi, Goto, Ai, Izumi-Nakaseko, Hiroko, Oikawa, Ichiro, Ikeda, Naoki, Matsuda, Kazuki, Takei, Yoshinori, Matsumoto, Akio, Kumagai, Yuji, Sugiyama, Atsushi

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Analysis of clinically-reported, memantine-induced cardiovascular adverse responses using the halothane-anesthetized dogs: Reverse translational study by Kambayashi, Ryuichi, Goto, Ai, Hagiwara-Nagasawa, Mihoko, Izumi-Nakaseko, Hiroko, Shinozaki, Makoto, Kawai, Shinichi, Matsumoto, Akio, Takei, Yoshinori, Sugiyama, Atsushi

“…Although NMDA receptor antagonist memantine is considered to be better tolerated than cholinesterase inhibitors on treating Alzheimer's disease, several types…”
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In vivo analysis of acute eletropharmacological effects of proton pump inhibitors using halothane-anesthetized dogs: a translational study of cardiovascular adverse events by Kambayashi, Ryuichi, Goto, Ai, Izumi-Nakaseko, Hiroko, Takei, Yoshinori, Sugiyama, Atsushi

“…Long-term use of proton pump inhibitors (PPIs) is known to clinically induce hypomagnesemia, increasing the risk toward QT-interval prolongation and lethal…”
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Phosphorylation of Nogo receptors suppresses Nogo signaling, allowing neurite regeneration by Takei, Yoshinori

“…The myelin-associated proteins Nogo-A, MAG, and OMgp transmit signals from oligodendrocytes into neurons through binding to Nogo receptors. Nogo signaling has…”
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Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones by Hagiwara-Nagasawa, Mihoko, Kambayashi, Ryuichi, Goto, Ai, Nunoi, Yoshio, Izumi-Nakaseko, Hiroko, Chiba, Koki, Wada, Takeshi, Takei, Yoshinori, Matsumoto, Akio, Sugiyama, Atsushi

“…Donepezil, an inhibitor for acetylcholinesterase used for patients with Alzheimer’s disease, has been shown to inhibit I Kr , occasionally inducing torsade de…”
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Roles of IK,ACh for perpetuating atrial fibrillation: Effects of atrial-selective K+ channel inhibitor AVE0118 and class I drugs on the persistent atrial fibrillation canine model by Kambayashi, Ryuichi, Goto, Ai, Izumi-Nakaseko, Hiroko, Takei, Yoshinori, Matsumoto, Akio, Kawai, Shinichi, Sugiyama, Atsushi

“…Since information is still limited whether atrial IK,ACh may become a potential therapeutic target to terminate persistent atrial fibrillation (AF), we…”
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Simultaneous analyses of hemodynamic and electrophysiological effects of oseltamivir along with its pharmacokinetic profile using the canine paroxysmal atrial fibrillation model by Kambayashi, Ryuichi, Goto, Ai, Onozato, Mayu, Izumi-Nakaseko, Hiroko, Takei, Yoshinori, Matsumoto, Akio, Kawai, Shinichi, Fukushima, Takeshi, Sugiyama, Atsushi

“…Since information of antiviral drug oseltamivir on the anti-atrial fibrillation (AF) property is still limited, we assessed it using the canine paroxysmal AF…”
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Imatinib induces diastolic dysfunction and ventricular early-repolarization delay in the halothane-anesthetized dogs: Class effects of tyrosine kinase inhibitors by Chiba, Koki, Kambayashi, Ryuichi, Onozato, Mayu, Goto, Ai, Izumi-Nakaseko, Hiroko, Takei, Yoshinori, Matsumoto, Akio, Tanaka, Koichiro, Kanda, Yasunari, Fukushima, Takeshi, Sugiyama, Atsushi

“…Imatinib has been reported to induce heart failure and/or QTc prolongation. To better understand their underlying mechanisms, we assessed its effects on…”
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Characterization of the electrocardiogram of microminipig in comparison with that of Clawn miniature swine: impacts of miniaturization of body size on electrocardiographic indices by GOTO, Ai, KAMBAYASHI, Ryuichi, SAITO, Hiroyuki, AKIE, Yasuki, IZUMI-NAKASEKO, Hiroko, TAKEI, Yoshinori, SUGIYAMA, Atsushi

“…Effects of body size reduction on electrocardiographic indices were examined using microminipigs in comparison with Clawn miniature swine (Clawn)…”
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Reverse translational analysis of clinically reported, lamotrigine-induced cardiovascular adverse events using the halothane-anesthetized dogs by Goto, Ai, Hagiwara-Nagasawa, Mihoko, Kambayashi, Ryuichi, Nunoi, Yoshio, Izumi-Nakaseko, Hiroko, Kawai, Shinichi, Takei, Yoshinori, Matsumoto, Akio, Sugiyama, Atsushi

“…Lamotrigine has been used for patients with epilepsy and/or bipolar disorder, overdose of which induced the hypotension, elevation of the atrial pacing…”
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Urinary Activin A is a novel biomarker reflecting renal inflammation and tubular damage in ANCA-associated vasculitis by Takei, Yoshinori, Takahashi, Shunsuke, Nakasatomi, Masao, Sakairi, Toru, Ikeuchi, Hidekazu, Kaneko, Yoriaki, Hiromura, Keiju, Nojima, Yoshihisa, Maeshima, Akito

“…Activin A, a member of the transforming growth factor-beta superfamily, is a critical modulator of inflammation and plays a key role in controlling the…”
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Identification of Urinary Activin A as a Novel Biomarker Reflecting the Severity of Acute Kidney Injury by Takahashi, Shunsuke, Nakasatomi, Masao, Takei, Yoshinori, Ikeuchi, Hidekazu, Sakairi, Toru, Kaneko, Yoriaki, Hiromura, Keiju, Nojima, Yoshihisa, Maeshima, Akito

“…Acute kidney injury (AKI) is a common but complex condition that is associated with increased morbidity and mortality. In the present study, we examined…”
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