Search Results - "TAKEI, Fumio"

Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients by Sugita, Kazunari, MD, PhD, Steer, Catherine A., Bsc, Martinez-Gonzalez, Itziar, PhD, Altunbulakli, Can, MSc, Morita, Hideaki, MD, PhD, Castro-Giner, Francesc, PhD, Kubo, Terufumi, MD, PhD, Wawrzyniak, Paulina, PhD, Rückert, Beate, PhD, Sudo, Katsuko, PhD, Nakae, Susumu, PhD, Matsumoto, Kenji, MD, PhD, O'Mahony, Liam, PhD, Akdis, Mübeccel, MD, PhD, Takei, Fumio, PhD, Akdis, Cezmi A., MD

“…Background Bronchial epithelial barrier leakiness and type 2 innate lymphoid cells (ILC2s) have been separately linked to asthma pathogenesis; however, the…”
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Group 2 innate lymphoid cell activation in the neonatal lung drives type 2 immunity and allergen sensitization by Steer, Catherine A., BSc, Martinez-Gonzalez, Itziar, PhD, Ghaedi, Maryam, DVM, Allinger, Patricia, BSc, Mathä, Laura, B.Sc, Takei, Fumio, PhD

“…Neonatal lung immunity is unique due to allergen-independent endogenous IL-33 mediated activation of group 2 innate lymphoid cells (ILC2s) that promote Th2…”
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Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production by Mathä, Laura, Shim, Hanjoo, Steer, Catherine A, Yin, Yi Han, Martinez-Gonzalez, Itziar, Takei, Fumio

“…Epidemiological studies have shown sex differences in prevalence of non-allergic asthma. Recent reports demonstrated negative effects of androgen signaling on…”
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Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation by Halim, Timotheus Y.F., Krauß, Ramona H., Sun, Ann C., Takei, Fumio

“…Overproduction of cytokines by T helper 2 (Th2) cells in the lung is thought to be a cause of asthma. Here we report that innate lymphocytes termed lung…”
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Flow cytometric analysis of innate lymphoid cells: challenges and solutions by Sadeghalvad, Mona, Khijakadze, Davit, Orangi, Mona, Takei, Fumio

“…IntroductionThe three groups of helper innate lymphoid cells (ILCs), namely ILC1, ILC2 and ILC3, have been identified by flow cytometry by combinations of cell…”
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Retinoic-Acid-Receptor-Related Orphan Nuclear Receptor Alpha Is Required for Natural Helper Cell Development and Allergic Inflammation by Halim, Timotheus Y.F., MacLaren, Aric, Romanish, Mark T., Gold, Matthew J., McNagny, Kelly M., Takei, Fumio

“…Natural helper (NH) cells are innate lymphoid cells (ILCs) that produce T helper-2 (Th2)-cell-type cytokines in the lung- and gut-associated lymphoid tissues…”
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Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis by Saranchova, Iryna, Han, Jeffrey, Zaman, Rysa, Arora, Hitesh, Huang, Hui, Fenninger, Franz, Choi, Kyung Bok, Munro, Lonna, Pfeifer, Cheryl G., Welch, Ian, Takei, Fumio, Jefferies, Wilfred A.

“…Type 2 innate lymphoid cells (ILC2) potentiate immune responses, however, their role in mediating adaptive immunity in cancer has not been assessed. Here, we…”
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ILC2 memory: Recollection of previous activation by Martinez‐Gonzalez, Itziar, Ghaedi, Maryam, Steer, Catherine A., Mathä, Laura, Vivier, Eric, Takei, Fumio

“…Summary Immunological memory, traditionally thought to belong to T and B cells, has now been extended to innate lymphocytes, including NK cells and ILC2s,…”
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Tissue Resident and Migratory Group 2 Innate Lymphoid Cells by Mathä, Laura, Takei, Fumio, Martinez-Gonzalez, Itziar

“…Group 2 innate lymphoid cells (ILC2s) are present in both mouse and human mucosal and non-mucosal tissues and implicated in initiating type 2 inflammation…”
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The Fate of Activated Group 2 Innate Lymphoid Cells by Mathä, Laura, Martinez-Gonzalez, Itziar, Steer, Catherine A, Takei, Fumio

“…Group 2 innate lymphoid cells (ILC2s) reside in both mucosal and non-mucosal tissues and play critical roles in the first line of defense against parasites and…”
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Correction: Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production by Mathä, Laura, Shim, Hanjoo, Steer, Catherine A, Yin, Yi Han, Martinez-Gonzalez, Itziar, Takei, Fumio

“…[This corrects the article DOI: 10.1371/journal.pone.0214286.]…”
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Lung group 2 innate lymphoid cells are trained by endogenous IL-33 in the neonatal period by Steer, Catherine A, Mathä, Laura, Shim, Hanjoo, Takei, Fumio

“…Group 2 innate lymphoid cells (ILC2s) in mouse lungs are activated by the epithelium-derived alarmin IL-33. Activated ILC2s proliferate and produce IL-5 and…”
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Common-Lymphoid-Progenitor-Independent Pathways of Innate and T Lymphocyte Development by Ghaedi, Maryam, Steer, Catherine A., Martinez-Gonzalez, Itziar, Halim, Timotheus Y.F., Abraham, Ninan, Takei, Fumio

“…All lymphocytes are thought to develop from common lymphoid progenitors (CLPs). However, lymphoid-primed multipotent progenitors (LMPPs) are more efficient…”
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Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity by Mathä, Laura, Romera-Hernández, Mónica, Steer, Catherine A., Yin, Yi Han, Orangi, Mona, Shim, Hanjoo, Chang, ChihKai, Rossi, Fabio M., Takei, Fumio

“…Group 2 innate lymphoid cells (ILC2s) are tissue resident in the lung and activated by inhaled allergens via epithelial-derived alarmins including IL-33…”
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G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program by Antignano, Frann, Braam, Mitchell, Hughes, Michael R, Chenery, Alistair L, Burrows, Kyle, Gold, Matthew J, Oudhoff, Menno J, Rattray, David, Halim, Timotheus Y, Cait, Alissa, Takei, Fumio, Rossi, Fabio M, McNagny, Kelly M, Zaph, Colby

“…Innate lymphoid cells (ILCs) are emerging as important regulators of homeostatic and disease-associated immune processes. Despite recent advances in defining…”
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UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells by Samudio, Ismael, Rezvani, Katayoun, Shaim, Hila, Hofs, Elyse, Ngom, Mor, Bu, Luke, Liu, Guoyu, Lee, Jason T.C., Imren, Suzan, Lam, Vivian, Poon, Grace F.T., Ghaedi, Maryam, Takei, Fumio, Humphries, Keith, Jia, William, Krystal, Gerald

“…Herein we demonstrate that oncolytic herpes simplex virus-1 (HSV-1) potently activates human peripheral blood mononuclear cells (PBMCs) to lyse leukemic cell…”
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A Dual Role for Talin in NK Cell Cytotoxicity: Activation of LFA-1-Mediated Cell Adhesion and Polarization of NK Cells by Mace, Emily M, Monkley, Susan J, Critchley, David R, Takei, Fumio

“…LFA-1 is critical for NK cell cytotoxicity because it mediates adhesion of NK cells to target cells. Talin is thought to associate with the cytoplasmic tail of…”
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Isolation and characterization of mouse innate lymphoid cells by Halim, Timotheus Y F, Takei, Fumio

“…Innate lymphoid cells (ILCs) are rare populations of cytokine-producing lymphocytes and are divided into three groups, namely ILC1, ILC2, and ILC3, based on…”
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The Rap GTPases Regulate Integrin-mediated Adhesion, Cell Spreading, Actin Polymerization, and Pyk2 Tyrosine Phosphorylation in B Lymphocytes by McLeod, Sarah J., Shum, Andrew J., Lee, Rosaline L., Takei, Fumio, Gold, Michael R.

“…Integrin-mediated adhesion plays an important role in B cell development and activation. Signaling initiated by antigens, chemokines, or phorbol esters can…”
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Innate lymphoid cell development by Ghaedi, Maryam, Takei, Fumio

“…Innate lymphoid cells (ILCs) mainly reside at barrier surfaces and regulate tissue homeostasis and immunity. ILCs are divided into 3 groups, group 1 ILCs,…”
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