Search Results - "TAKEDA, Setsuo"

Pretreatment with S-1, an Oral Derivative of 5-Fluorouracil, Enhances Gemcitabine Effects in Pancreatic Cancer Xenografts by NAKAHIRA, Shin, NAKAMORI, Shoji, NAGANO, Hiroaki, DONO, Keizo, UMESHITA, Koji, SAKON, Masato, MONDEN, Morito, TSUJIE, Masanori, TAKEDA, Setsuo, SUGIMOTO, Keishi, TAKAHASHI, Yuji, OKAMI, Jiro, MARUBASHI, Shigeru, MIYAMOTO, Atsushi, TAKEDA, Yutaka

“…Background: The systemic administration of gemcitabine (GEM) has been accepted as a standard treatment for patients with advanced pancreatic cancer. The major…”
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Preliminary study on the optimal dosage schedule for oral tegafur/uracil (UFT) chemotherapy by Sadahiro, Sotaro, Mukai, Masaya, Tokunaga, Nobuhiro, Tajima, Tomoo, Makuuchi, Hiroyasu, Yoshida, Masahiko, Okabe, Hiroyuki, Uchida, Junji, Takeda, Setsuo, Unemi, Norio

“…We evaluated a new dose-intensive schedule for oral UFT (tegafur and uracil in a molar ratio of 1:4) administered for 5 consecutive days followed by 2…”
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Synthesis and Antitumor Activities of 5'-O-Aminoacyl-3'-O-benzyl Derivatives of 2'-Deoxy-5-fluorouridine and Related Compounds by UEMURA, Atsuhiko, TADA, Yukio, TAKEDA, Setsuo, UCHIDA, Junji, YAMASHITA, Jun-ichi

“…Various O-alkyl derivatives of 2'-deoxy-5-fluorouridine (FUdR) were synthesized and their antitumor activities in mice bearing sarcoma 180 (s.c.-p.o.) were…”
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Antitumor Agents. I. DNA Topoisomerase II Inhibitory Activity and the Structural Relationship of Podophyllotoxin Derivatives as Antitumor Agents by TERADA, Tadafumi, FUJIMOTO, Katsuhiko, NOMURA, Makoto, YAMASHITA, Jun-ichi, KOBUNAI, Takashi, TAKEDA, Setsuo, WIERZBA, Konstanty, YAMADA, Yuji, YAMAGUCHI, Hideo

“…Various podophyllotoxin derivatives from desoxypodophyllotoxin (DPT) were synthesized to examine the structural relationships between the biological…”
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Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats by Shirasaka, T, Nakano, K, Takechi, T, Satake, H, Uchida, J, Fujioka, A, Saito, H, Okabe, H, Oyama, K, Takeda, S, Unemi, N, Fukushima, M

“…The purpose of this study was to establish a nude rat orthotopic (organ-specific) human colorectal cancer model as an in vivo secondary screen for general…”
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Terpenoids. LIII. : Antitumor Activity of Trichorabdals and Related Compounds by FUJI, Kaoru, NODE, Manabu, SAI, Midori, FUJITA, Eiichi, TAKEDA, Setsuo, UNEMI, Norio

“…Among the three types, enmein-, oridonin-, and trichorabdal-type, of diterpenoids from Rabdosia trichocarpa, the latter showed the highest antitumor activity…”
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Antitumor Agents. II : Regio- and Stereospecific Syntheses of 1-β-Alkyl-1-desoxypodophyllotoxin Derivatives and Biological Activity by TERADA, Tadafumi, FUJIMOTO, Katsuhiko, NOMURA, Makoto, YAMASHITA, Jun-ichi, WIERZBA, Konstanty, KOBUNAI, Takashi, TAKEDA, Setsuo, MINAMI, Yoshinori, YOSHIDA, Ken-ichirou, YAMAGUCHI, Hideo, YAMADA, Yuji

“…1-β-Alkyl derivatives of 1-desoxypodophyllotoxin were synthesized, and their cytotoxicity and inhibitory effects on DNA topoisomerase II (Topo-II) and tubulin…”
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Antitumor activity and low intestinal toxicity of S-1, a new formulation of oral tegafur, in experimental tumor models in rats by Takechi, T., Nakano, Koushi, Uchida, Junji, Mita, Akira, Toko, Kisako, Takeda, Setsuo, Unemi, Norio, Shirasaka, Tetsuhiko

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Antitumor activity of FTC-092, a masked 5-trifluoromethyl-2'-deoxyuridine derivative by TAKEDA, S, YAMASHITA, J.-I, SAITO, H, UCHIDA, J, ATAKA, H, YAMADA, Y, UNEMI, N, WATAYA, Y, HAYATSU, H

“…1-(3-O-Benzyl-2-deoxy-beta-D-ribofuranosyl)-5-trifluoromethyl-2,4(1H,3)- pyrimidinedione (FTC-092), a fluorinated pyrimidine derivative, appeared to be…”
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Schedule-dependent therapeutic effects of gemcitabine combined with uracil-tegafur in a human pancreatic cancer xenograft model by Tsujie, Masanori, Nakamori, Shoji, Nakahira, Shin, Takeda, Setsuo, Takahashi, Yuji, Hayashi, Nobuyasu, Okami, Jiro, Nagano, Hiroaki, Dono, Keizo, Umeshita, Koji, Sakon, Masato, Monden, Morito

“…Gemcitabine is taken up by cells mainly via human equilibrative nucleoside transporter 1 (hENT1). Pretreatment of cancer cell lines with 5-fluorouracil (5-FU)…”
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Preclinical antitumor efficacy of S-1: a new oral formulation of 5-fluorouracil on human tumor xenografts by Fukushima, M, Satake, H, Uchida, J, Shimamoto, Y, Kato, T, Takechi, T, Okabe, H, Fujioka, A, Nakano, K, Ohshimo, H, Takeda, S, Shirasaka, T

“…S-1 is a new oral formulation of 5-fluorouracil (5-FU) consisted of 1M tegafur, 0.4M 5-chloro-2,4-dihydroxypyridine that inhibits a degradation of 5-FU, and 1M…”
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Terpenoids. L. Antitumor activity of diterpenoids from Rabdosia shikokiana var. occidentalis by Fuji, K, Node, M, Ito, N, Fujita, E, Takeda, S, Unemi, N

“…In vitro antitumor activity of diterpenoids isolated from Rabdosia shikokiana var. occidentalis was determined against HeLa cells. Some of these compounds…”
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Studies on Antitumor Agents. VII. Antitumor Activities of O-Alkoxyalkyl Derivatives of 2'-Deoxy-5-trifluoromethyluridine by YAMASHITA, JUN-ICHI, TAKEDA, SETSUO, MATSUMOTO, HIROSHI, UNEMI, NORIO, YASUMOTO, MITSUGI

“…Various O-alkoxyalkyl derivatives of 2'-deoxy-5-trifluoromethyluridine (F3Thd) were synthesized, and the antitumor activities of the compounds against sarcoma…”
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Antitumor activity of diterpenoids, trichorabdals A, B, and C, and the related compounds: synergism of two active sites by Node, M, Sai, M, Fuji, K, Fujita, E, Takeda, S

“…Antitumor activity of Rabdosia diterpenoids and the related compounds against Ehrlich ascites carcinoma has been studied. In addition to α-methylene…”
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Studies on Antitumor Agents. VI. Syntheses and Antitumor Activities of Acyl Derivatives of 2'-Deoxy-5-trifluoromethyluridine by YAMASHITA, JUN-ICHI, TAKEDA, SETSUO, MATSUMOTO, HIROSHI, TERADA, TADAFUMI, UNEMI, NORIO, YASUMOTO, MITSUGI

“…Various O-acyl and N-acyl derivatives of 2'-deoxy-5-trifluoromethyluridine (F3Thd) were synthesized; namely 5'-O-acyl, 3', 5'-di-O-acyl, N3-acyl, 3',…”
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STUDIES ON COMBINATION THERAPY WITH 1-(TETRAHYDRO-2-FURANYL)-5-FLUOROURACIL PLUS URACIL. II: Effects of Uracil on In vitro Metabolisms of 1-(Tetrahydro-2-furanyl)-5-fluorouracil and 5-Fluorouracil by UNEMI, NORIO, TAKEDA, SETSUO

“…The effects of uracil on the in vitro metabolisms of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) and 5-fluorouracil (5-UF) were studied. 3H-FT and 3H-uracil…”
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Studies on Antitumor Agents. IV. Syntheses and Antitumor Activities of Compounds related to 1-(Tetrahydro-2-furanyl)-5-fluorouracil Metabolites by UEDA, SHUICHI, TAKEDA, SETSUO, YAMAWAKI, ICHIRO, YAMASHITA, JUNICHI, YASUMOTO, MITSUGI, HASHIMOTO, SADAO

“…A hydroxylated metabolite of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT), 1-(trans-3-hydroxytetrahydro-2-furanyl)-5-fluorouracil (trans-3'-OH-FT, VIII) and…”
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Effect of 1,3,3,5,5-pentaziridino-1-thia-2,4,6-triaza-3,5-diphosphorine-1-oxide, a new antitumor agent with inorganic ring, on various experimental tumors by Kitazato, K, Takeda, S, Unemi, N

“…1,3,3,5,5-Pentaziridino-1-thia-2,4,6-triaza-3,5-diphosphorine-1-oxide (SOAz), a new antitumor agent, was evaluated for antitumor activity against various…”
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Antitumor activities of harringtonine and homoharringtonine, cephalotaxus alkaloids which are active principles from plant by intraperitoneal and oral administration by Takeda, S, Yajima, N, Kitazato, K, Unemi, N

“…Antitumor activities of harringtonine(HA) and homoharringtonine(HO) both belong to cephalotaxus alkaloids were compared with those of vinca alkaloids,…”
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Antitumor agents. 3. Synthesis and biological activity of 4 beta-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents by Terada, T, Fujimoto, K, Nomura, M, Yamashita, J, Wierzba, K, Yamazaki, R, Shibata, J, Sugimoto, Y, Yamada, Y, Kobunai, T

“…A series of 4 beta-alkyl (7-10), 4 beta-aminoalkyl (12a-y), and 4 beta-amidoalkyl derivatives (14a-g) of 4'-O-demethyl-4-desoxypodophyllotoxin have been…”
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