Anti-glomerular basement membrane antibody-mediated glomerulonephritis remarkably improved by pulse therapy with methylprednisolone, plasmapheresis and continuous heparin infusion

The patient, a 28 year-old-man, was admitted to a hospital because of general fatigue and fever. He was pointed out renal dysfunction and was transfered to Nagasaki Uni-versity Hospital. The laboratory data on admission showed moderate azotemia (BUN 43 mg/dl, Cr 5.4 mg/dl). A percutaneous renal biop...

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Published in:	Nihon Jinzo Gakkai shi Vol. 31; no. 11; pp. 1197 - 1204
Main Authors:	TAKASHIMA, KAZUHIKO, SYUKUWA, SABURO, IWANAGA, NOBUAKI, SAKATA, HIDEO, YASUMORI, RYOUKICHI, TADOKORO, MASATO, KOHARA, SUGURU, TANAKA, TAMIO, MATSUO, SHINICHIROU, MURAYA, YOSHIAKI, HIRAI, YOSHINOBU, HARADA, TAKASHI, HARA, KOUHEI, TAGUCHI, TAKASHI, TAKEBAYASI, SHIGEO
Format:	Journal Article
Language:	Japanese
Published:	Japan Japanese Society of Nephrology 01-11-1989
Subjects:	Adult anti-GBM antibody mediated glomerulonephritis Antibodies - immunology Autoantibodies continuous heparin infusion Glomerulonephritis, Membranous - immunology Glomerulonephritis, Membranous - pathology Glomerulonephritis, Membranous - therapy Heparin - administration & dosage Humans Immunoglobulin G - analysis Infusions, Intravenous Kidney - immunology Kidney - pathology Male Methylprednisolone - administration & dosage plasmaphereresis Plasmapheresis pulse therapy
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Summary:	The patient, a 28 year-old-man, was admitted to a hospital because of general fatigue and fever. He was pointed out renal dysfunction and was transfered to Nagasaki Uni-versity Hospital. The laboratory data on admission showed moderate azotemia (BUN 43 mg/dl, Cr 5.4 mg/dl). A percutaneous renal biopsy on admission revealed a diffuse crescentic glomerulonephritis. A direct immunofluorescence of renal biopsy showed a linear pattern for IgG along the glomerular basement membrane. Radioimmunoassay of his serum for circulationg anti-GBM antibody was strongly positive. Aggressive treatment with pulse therapy (methylprednisolone), plasmapheresis, and continuous heparin infusion was performed. He had markedly recovered from renal failure and escaped hemodialysis. The patient is making satisfactory process after 3 years.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Report-3 ObjectType-Case Study-4
ISSN:	0385-2385 1884-0728
DOI:	10.14842/jpnjnephrol1959.31.1197