Search Results - "TAKASHI UZU"

Proximal Renal Tubular Dysfunction Induces Severe Hypocalcemia in the Elderly by Uzu, Takashi

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Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy by Tagawa, Atsuko, Yasuda, Mako, Kume, Shinji, Yamahara, Kosuke, Nakazawa, Jun, Chin-Kanasaki, Masami, Araki, Hisazumi, Araki, Shin-Ichi, Koya, Daisuke, Asanuma, Katsuhiko, Kim, Eun-Hee, Haneda, Masakazu, Kajiwara, Nobuyuki, Hayashi, Kazuyuki, Ohashi, Hiroshi, Ugi, Satoshi, Maegawa, Hiroshi, Uzu, Takashi

“…Overcoming refractory massive proteinuria remains a clinical and research issue in diabetic nephropathy. This study was designed to investigate the…”
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Emerging role of podocyte autophagy in the progression of diabetic nephropathy by Yasuda-Yamahara, Mako, Kume, Shinji, Tagawa, Atsuko, Maegawa, Hiroshi, Uzu, Takashi

“…Glomerular podocytes are pivotal in maintaining glomerular filtration barrier function. As severe podocyte injury results in proteinuria in patients with…”
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Fanconi Syndrome Associated with Long-term Treatment with Zoledronate by Katsunuma, Rinko, Mitsumoto, Kensuke, Mizumoto, Aya, Hirai, Yuri, Nakauchi, Chiaki, Uzu, Takashi

“…Intravenous bisphosphonate therapy is used to prevent fractures in the management of bone metastasis. However, it may induce renal damage. We herein report an…”
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Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney by Kume, Shinji, Uzu, Takashi, Horiike, Kihachiro, Chin-Kanasaki, Masami, Isshiki, Keiji, Araki, Shin-Ichi, Sugimoto, Toshiro, Haneda, Masakazu, Kashiwagi, Atsunori, Koya, Daisuke

“…Mitochondrial oxidative damage is a basic mechanism of aging, and multiple studies demonstrate that this process is attenuated by calorie restriction (CR)…”
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Obesity-Mediated Autophagy Insufficiency Exacerbates Proteinuria-induced Tubulointerstitial Lesions by YAMAHARA, Kosuke, KUME, Shinji, MATSUSAKA, Taiji, KASHIWAGI, Atsunori, MAEGAWA, Hiroshi, UZU, Takashi, KOYA, Daisuke, TANAKA, Yuki, MORITA, Yoshikata, CHIN-KANASAKI, Masami, ARAKI, Hisazumi, ISSHIKI, Keiji, ARAKI, Shin-Ichi, HANEDA, Masakazu

“…Obesity is an independent risk factor for renal dysfunction in patients with CKDs, including diabetic nephropathy, but the mechanism underlying this connection…”
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Reversible hypoglycemic encephalopathy in a nondiabetic patient with end‐stage kidney disease by Hirai, Yuri, Mitsumoto, Kensuke, Uzu, Takashi

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Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy by Kume, Shinji, Koya, Daisuke, Uzu, Takashi, Maegawa, Hiroshi

“…Diabetic nephropathy is the leading cause of end-stage renal disease worldwide. The multipronged drug approach still fails to fully prevent the onset and…”
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Emerging role of mammalian autophagy in ketogenesis to overcome starvation by Takagi, Ayano, Kume, Shinji, Maegawa, Hiroshi, Uzu, Takashi

“…Autophagy is essential for the survival of lower organisms under conditions of nutrient depletion. However, whether autophagy plays a physiological role in…”
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Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes by Yasuda, Mako, Tanaka, Yuki, Kume, Shinji, Morita, Yoshikata, Chin-Kanasaki, Masami, Araki, Hisazumi, Isshiki, Keiji, Araki, Shin-ichi, Koya, Daisuke, Haneda, Masakazu, Kashiwagi, Atsunori, Maegawa, Hiroshi, Uzu, Takashi

“…Podocyte apoptosis is a potent mechanism of proteinuria in diabetic nephropathy. More detailed mechanistic insight into podocyte apoptosis is needed to better…”
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Crystalline Light Chain Casts and Hypercalcemia Induced Acute Kidney Injury: A Rare Presentation of Multiple Myeloma by Nishigaito, Toshiya, Mitsumoto, Kensuke, Katsunuma, Rinko, Hirai, Yuri, Yamashita, Chikako, Mizumoto, Aya, Uzu, Takashi

“…The most common cause of acute kidney injury (AKI) in multiple myeloma is light-chain cast nephropathy (LCCN), which consists of a light chain and…”
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Predictive Effects of Urinary Liver-Type Fatty Acid―Binding Protein for Deteriorating Renal Function and Incidence of Cardiovascular Disease in Type 2 Diabetic Patients Without Advanced Nephropathy by ARAKI, Shin-Ichi, HANEDA, Masakazu, KOYA, Daisuke, SUGAYA, Takeshi, ISSHIKI, Keiji, KUME, Shinji, KASHIWAGI, Atsunori, UZU, Takashi, MAEGAWA, Hiroshi

“…To improve prognosis, it is important to predict the incidence of renal failure and cardiovascular disease in type 2 diabetic patients before the progression…”
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Idiopathic Chyluria with Nephrotic-range Proteinuria and Hypothyroidism by Uzu, Takashi, Takamori, Keisei, Fujino, Yoshihiko, Fukui, Tatsunari

“…The patient was a 75-year-old man who was admitted to our hospital because of fatigue, leg edema and heavy proteinuria. Due to his cloudy urine and elevated…”
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Structural and functional changes in the kidneys of high-fat diet-induced obese mice by Deji, Naoko, Kume, Shinji, Araki, Shin-Ichi, Soumura, Mariko, Sugimoto, Toshiro, Isshiki, Keiji, Chin-Kanasaki, Masami, Sakaguchi, Masayoshi, Koya, Daisuke, Haneda, Masakazu, Kashiwagi, Atsunori, Uzu, Takashi

“…Metabolic syndrome has been reported to be associated with chronic kidney disease, but the mechanisms remain unclear. Although feeding of a high-fat diet (HFD)…”
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SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells by Koyama, Tetsuro, Kume, Shinji, Koya, Daisuke, Araki, Shin-ichi, Isshiki, Keiji, Chin-Kanasaki, Masami, Sugimoto, Toshiro, Haneda, Masakazu, Sugaya, Takeshi, Kashiwagi, Atsunori, Maegawa, Hiroshi, Uzu, Takashi

“…Free fatty acid (FFA)-mediated renal lipotoxicity is associated with the progression of tubulointerstitial inflammation in proteinuric kidney disease. SIRT3 is…”
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Randomized trial of an intensified, multifactorial intervention in patients with advanced‐stage diabetic kidney disease: Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan) by Shikata, Kenichi, Haneda, Masakazu, Ninomiya, Toshiharu, Koya, Daisuke, Suzuki, Yoshiki, Suzuki, Daisuke, Ishida, Hitoshi, Akai, Hiroaki, Tomino, Yasuhiko, Uzu, Takashi, Nishimura, Motonobu, Maeda, Shiro, Ogawa, Daisuke, Miyamoto, Satoshi, Makino, Hirofumi

“…Aims/Introduction We evaluated the efficacy of multifactorial intensive treatment (IT) on renal outcomes in patients with type 2 diabetes and advanced‐stage…”
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1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells by Tanaka, Yuki, Kume, Shinji, Araki, Hisazumi, Nakazawa, Jun, Chin-Kanasaki, Masami, Araki, Shin-ichi, Nakagawa, Fumiyuki, Koya, Daisuke, Haneda, Masakazu, Maegawa, Hiroshi, Uzu, Takashi

“…Free fatty acid-bound albumin (FFA-albumin)-related oxidative stress is involved in the pathogenesis of proximal tubular cell (PTC) damage and subsequent renal…”
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Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet by KUME, Shinji, UZU, Takashi, HANEDA, Masakazu, KASHIWAGI, Atsunori, KOYA, Daisuke, ARAKI, Shin-Ichi, SUGIMOTO, Toshiro, ISSHIKI, Keiji, CHIN-KANASAKI, Masami, SAKAGUCHI, Masayoshi, KUBOTA, Naoto, TERAUCHI, Yasuo, KADOWAKI, Takashi

“…Metabolic syndrome is associated with increased risk of chronic kidney disease, and the renal injury in patients with metabolic syndrome may be a result of…”
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Renoprotective effect of DPP-4 inhibitors against free fatty acid-bound albumin-induced renal proximal tubular cell injury by Tanaka, Yuki, Kume, Shinji, Chin-Kanasaki, Masami, Araki, Hisazumi, Araki, Shin-ichi, Ugi, Satoshi, Sugaya, Takeshi, Uzu, Takashi, Maegawa, Hiroshi

“…Dipeptidyl peptidase (DPP)-4 inhibitors, a new class of antidiabetic agent, have recently been suggested to exert pleiotropic effects beyond glucose lowering…”
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Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation by Takagi, Ayano, Kume, Shinji, Kondo, Motoyuki, Nakazawa, Jun, Chin-Kanasaki, Masami, Araki, Hisazumi, Araki, Shin-ichi, Koya, Daisuke, Haneda, Masakazu, Chano, Tokuhiro, Matsusaka, Taiji, Nagao, Kenji, Adachi, Yusuke, Chan, Lawrence, Maegawa, Hiroshi, Uzu, Takashi

“…Autophagy is an intracellular degradation system activated, across species, by starvation. Although accumulating evidence has shown that mammalian autophagy is…”
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