Search Results - "TAKASAKI, WATARU"

MicroRNA profiles in a monkey testicular injury model induced by testicular hyperthermia by Sakurai, Ken, Mikamoto, Kei, Shirai, Makoto, Iguchi, Takuma, Ito, Kazumi, Takasaki, Wataru, Mori, Kazuhiko

“…To characterize microRNAs (miRNAs) involved in testicular toxicity in cynomolgus monkeys, miRNA profiles were investigated using next‐generation sequencing…”
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Effect of inter-individual variability in human liver cytochrome P450 isozymes on cyclophosphamide-induced micronucleus formation by Kishino, Yuki, Hasegawa, Tomoko, Kato, Ayako, Nishiya, Yumi, Rozhnal, Veronika, Watanabe, Kyoko, Takasaki, Wataru, Yamoto, Takashi, Mori, Kazuhiko

“…•A wide inter-individual variation of CYP activity was observed among 78 donors.•Diversity of CYP activity was partially correlated with genetic…”
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Neutrophil gelatinase-associated lipocalin, a sensitive urinary biomarker of acute kidney injury in dogs receiving gentamicin by Kai, Kiyonori, Yamaguchi, Takashi, Yoshimatsu, Yu, Kinoshita, Junzo, Teranishi, Munehiro, Takasaki, Wataru

“…A sensitive urinary biomarker for acute kidney injury (AKI) was investigated in beagle dogs with nephrotoxicity induced by gentamicin. Gentamicin sulphate at…”
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A monkey model of acetaminophen-induced hepatotoxicity; phenotypic similarity to human by Tamai, Satoshi, Iguchi, Takuma, Niino, Noriyo, Mikamoto, Kei, Sakurai, Ken, Sayama, Ayako, Shimoda, Hitomi, Takasaki, Wataru, Mori, Kazuhiko

“…Species-specific differences in the hepatotoxicity of acetaminophen (APAP) have been shown. To establish a monkey model of APAP-induced hepatotoxicity, which…”
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Metabolomic analysis of arginine metabolism in acute hepatic injury in rats by Saitoh, Wataru, Yamauchi, Shusuke, Watanabe, Kyoko, Takasaki, Wataru, Mori, Kazuhiko

“…To clarify the relationship between arginine metabolism and hepatic injury, metabolomic analysis was performed in rats treated with 3 representative…”
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MicroRNA profiling in ethylene glycol monomethyl ether-induced monkey testicular toxicity model by Sakurai, Ken, Mikamoto, Kei, Shirai, Makoto, Iguchi, Takuma, Ito, Kazumi, Takasaki, Wataru, Mori, Kazuhiko

“…To establish and characterize ethylene glycol monomethyl ether (EGME)-induced testicular toxicity model in cynomolgus monkeys, EGME at 0 or 300 mg/kg was…”
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Effect of buprenorphine on genotoxicity evaluation of chemicals by the rat liver micronucleus test with partial hepatectomy by Itoh, Satoru, Nagata, Mayumi, Hattori, Chiharu, Takasaki, Wataru

“…In the view of animal welfare considerations, we investigated the suitability of modifying the rat liver micronucleus test with partial hepatectomy to include…”
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The Process and Development Mechanism of Age-related Fibrosis in the Pancreatic Islets of Sprague-Dawley Rats: Immunohistochemical Detection of Myofibroblasts and Suppression Effect by Estrogen Treatment by Imaoka, Masako, Jindo, Toshimasa, Takasaki, Wataru

“…The mechanism of spontaneous islet fibrosis in Sprague-Dawley rats was investigated. Using sections of the pancreas in naive males aged 26 to 102 weeks old and…”
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Localization of connexin 32 in spontaneous liver lesions of mice by IGARASHI, Isao, MAKINO, Toshihiko, KAI, Kiyonori, TERANISHI, Munehiro, TAKASAKI, Wataru, SATOH, Hiroshi, FURUHAMA, Kazuhisa

“…We examined the localization of connexin 32 (Cx32), a component of gap junctions, in 24-month-old male B6C3F1 mice with spontaneously occurring hepatocellular…”
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Hepatic glutathione contributes to attenuation of thioacetamide-induced hepatic necrosis due to suppression of oxidative stress in diet-induced obese mice by Shirai, Makoto, Matsuoka, Miho, Makino, Toshihiko, Kai, Kiyonori, Teranishi, Munehiro, Takasaki, Wataru

“…We previously reported that hepatic necrosis induced by thioacetamide (TA), a hepatotoxicant, was attenuated in mice fed a high-fat diet (HFD mice) in…”
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Background Lesions during a 24-Month Observation Period in Connexin 32-Deficient Mice by IGARASHI, Isao, MAKINO, Toshihiko, SUZUKI, Yoko, KAI, Kiyonori, TERANISHI, Munehiro, TAKASAKI, Wataru, FURUHAMA, Kazuhisa

“…Connexin 32 (Cx32) is a major gap junction protein in the liver. Neoplastic and non-neoplastic lesions were examined in Cx32-deficient (Cx32KO) mice maintained…”
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Evaluation of hepatic glutathione transferase Mu 1 and Theta 1 activities in humans and mice using genotype information by Arakawa, Shingo, Fujimoto, Kazunori, Kato, Ayako, Endo, Seiko, Fukahori, Aiko, Shinagawa, Akira, Fischer, Thomas, Mueller, Juergen, Takasaki, Wataru

“…We investigated the impact of glutathione transferases Mu 1 (GSTM1)- and glutathione transferase Theta 1 (GSTT1)-null genotypes on hepatic GST activities in…”
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Evaluation of canine T-cell dependent antibody response to the primary and secondary immunization with keyhole limpet hemocyanin by Kawai, Ryota, Aida, Tetsuo, Hattori, Hiroyuki, Furukawa, Tadashi, Mori, Kazuhiko, Takasaki, Wataru, Takahashi, Nobuyuki, Kawada, Teruo

“…T-cell dependent antibody response (TDAR) incorporating both primary and secondary responses to keyhole limpet hemocyanin (KLH) in canine models have not yet…”
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MicroRNA profling in ethylene glycol monomethyl ether-induced monkey testicular toxicity model by Sakurai, Ken, Mikamoto, Kei, Shirai, Makoto, Iguchi, Takuma, Ito, Kazumi, Takasaki, Wataru, Mori, Kazuhiko

“…To establish and characterize ethylene glycol monomethyl ether (EGME)-induced testicular toxicity model in cynomolgus monkeys, EGME at 0 or 300 mg/kg was…”
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Effect of glutathione (GSH) depletion on DNA damage and blood chemistry in aged and young rats by Hashimoto, Kazuyuki, Takasaki, Wataru, Yamoto, Takashi, Manabe, Sunao, Sato, Itaru, Tsuda, Shuji

“…DNA is damaged by reactive oxygen species (ROS) and such damage is age-dependent. Blood chemical parameters also change age-dependently. Glutathione (GSH)…”
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Subcutaneous Soft Tissue Sarcoma with Rhabdoid Features in a Dog by Sayama, Ayako, Okado, Keiko, Imaoka, Masako, Yokouchi, Yusuke, Jindo, Toshimasa, Takasaki, Wataru

“…A nine-year-old male beagle dog had a white spherical mass in the subcutis of the left lumbar region. Microscopically, spindle to oval cells diffusely…”
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DNA DAMAGE MEASURED BY COMET ASSAY AND 8-OH-dG FORMATION RELATED TO BLOOD CHEMICAL ANALYSES IN AGED RATS by HASHIMOTO, Kazuyuki, TAKASAKI, Wataru, SATO, Itaru, TSUDA, Shuji

“…To evaluate the effects of aging on DNA damage, spontaneous and chemical-induced DNA damage and its repair were examined using comet assays at pH 9, 12.1 and…”
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Generation and Functional Characterization of Mice with a Disrupted Glutathione S-Transferase, Theta 1 Gene by FUJIMOTO, Kazunori, ARAKAWA, Shingo, WATANABE, Toshiyuki, YASUMO, Hiroaki, ANDO, Yosuke, TAKASAKI, Wataru, MANABE, Sunao, YAMOTO, Takashi, ODA, Sen-Ichi

“…Glutathione S -transferase (GST) theta 1 (GSTT1) has been regarded as one of the key enzymes involved in phase II reactions because of its unique substrate…”
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A NOVEL MODEL OF CONTINUOUS DEPLETION OF GLUTATHIONE IN MICE TREATED WITH L-BUTHIONINE (S,R)-SULFOXIMINE by WATANABE, Toshiyuki, SAGISAKA, Hideki, ARAKAWA, Shingo, SHIBAYA, Yukari, WATANABE, Mayumi, IGARASHI, Isao, TANAKA, Kohji, TOTSUKA, Shigeo, TAKASAKI, Wataru, MANABE, Sunao

“…L-Buthionine (S,R)-sulfoximine (BSO), an inhibitor of glutathione (GSH) synthesis, was administered to mice via drinking water for 14 days in order to…”
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Age-related differences of QT interval and autonomic nervous system activity in female cynomolgus monkeys by Ishizaka, Tomomichi, Yoshimatsu, Yu, Ozawa, Minori, Kimotsuki, Tomofumi, Takasaki, Wataru, Manabe, Sunao, Yasuda, Mitsuya

“…Cynomolgus monkeys are used in in vivo toxicological studies to evaluate the effects of drug candidates on the cardiovascular system, especially the effects of…”
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