Search Results - "TAKASAKI, TERUAKI"

ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer by Sugiura, Reiko, Satoh, Ryosuke, Takasaki, Teruaki

“…The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified by cell proliferation, differentiation, motility, and survival…”
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More than Just an Immunosuppressant: The Emerging Role of FTY720 as a Novel Inducer of ROS and Apoptosis by Sugiura, Reiko, Satoh, Ryosuke, Hagihara, Kanako, Takasaki, Teruaki

“…Fingolimod hydrochloride (FTY720) is a first-in-class of sphingosine-1-phosphate (S1P) receptor modulator approved to treat multiple sclerosis by its…”
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Fission Yeast PUF Proteins Puf3 and Puf4 Are Novel Regulators of PI4P5K Signaling by Satoh, Ryosuke, Tanaka, Taemi, Yoshida, Nobuyasu, Tanaka, Chiaki, Takasaki, Teruaki, Sugiura, Reiko

“…Phosphatidylinositol-4-phosphate 5-kinase (PI4P5K) is a highly conserved enzyme that generates phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) by…”
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Ar s enite treatment induces Hsp90 aggregates distinct from conventional stress granules in fission yeast by Tomimoto, Naofumi, Takasaki, Teruaki, Sugiura, Reiko

“…Various stress conditions, such as heat stress (HS) and oxidative stress, can cause biomolecular condensates represented by stress granules (SGs) via…”
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Down‐regulation of dual‐specificity phosphatase 6, a negative regulator of oncogenic ERK signaling, by ACA‐28 induces apoptosis in NIH/3T3 cells overexpressing HER2/ErbB2 by Kanda, Yuki, Mizuno, Ayami, Takasaki, Teruaki, Satoh, Ryosuke, Hagihara, Kanako, Masuko, Takashi, Endo, Yuichi, Tanabe, Genzoh, Sugiura, Reiko

“…Dual‐specificity phosphatase 6 (DUSP6) is a key negative feedback regulator of the member of the RAS‐ERK MAPK signaling pathway that is associated with…”
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Chemical genetic analysis of FTY720‐ and Ca2+‐sensitive mutants reveals a functional connection between FTY720 and membrane trafficking by Hagihara, Kanako, Kanda, Yuki, Ishida, Kouki, Satoh, Ryosuke, Takasaki, Teruaki, Maeda, Takuya, Sugiura, Reiko

“…FTY720, a sphingosine‐1‐phosphate (S1P) analog, is used as an immune modulator to treat multiple sclerosis. Accumulating evidence has suggested the mode of…”
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Distinct modes of stress granule assembly mediated by the KH‐type RNA‐binding protein Rnc1 by Satoh, Ryosuke, Hara, Nobuki, Kawasaki, Aki, Takasaki, Teruaki, Sugiura, Reiko

“…We have previously identified the KH‐type RNA‐binding protein Rnc1 as an important regulator of the posttranscriptional expression of the MAPK phosphatase Pmp1…”
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Broad chromosomal domains of histone modification patterns in C. elegans by Liu, Tao, Rechtsteiner, Andreas, Egelhofer, Thea A, Vielle, Anne, Latorre, Isabel, Cheung, Ming-Sin, Ercan, Sevinc, Ikegami, Kohta, Jensen, Morten, Kolasinska-Zwierz, Paulina, Rosenbaum, Heidi, Shin, Hyunjin, Taing, Scott, Takasaki, Teruaki, Iniguez, A Leonardo, Desai, Arshad, Dernburg, Abby F, Kimura, Hiroshi, Lieb, Jason D, Ahringer, Julie, Strome, Susan, Liu, X Shirley

“…Chromatin immunoprecipitation identifies specific interactions between genomic DNA and proteins, advancing our understanding of gene-level and chromosome-level…”
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The histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny by Rechtsteiner, Andreas, Ercan, Sevinc, Takasaki, Teruaki, Phippen, Taryn M, Egelhofer, Thea A, Wang, Wenchao, Kimura, Hiroshi, Lieb, Jason D, Strome, Susan

“…Methylation of histone H3K36 in higher eukaryotes is mediated by multiple methyltransferases. Set2-related H3K36 methyltransferases are targeted to genes by…”
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Stress granules as a feedback mechanism of MAPK signaling by sequestering PKC/Pck2 by Kanda, Yuki, Satoh, Ryosuke, Takasaki, Teruaki, Tomimoto, Naofumi, Tsuchiya, Kiko, Tsai, Chun An, Tanaka, Taemi, Kyomoto, Shu, Hamada, Kozo, Fujiwara, Toshinobu, Sugiura, Reiko

“…The PKC signaling is a highly conserved signaling module, which plays a central role in a myriad of physiological processes, ranging from cell proliferation to…”
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Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies on an ERK MAPK signaling modulator, ACA-28 by Satoh, Ryosuke, Hamada, Naoya, Yamada, Ami, Kanda, Yuki, Ishikawa, Fumihiro, Takasaki, Teruaki, Tanabe, Genzoh, Sugiura, Reiko

“…[Display omitted] •ACA-28 (2a), an ERK-dependent apoptosis inducer preferentially kills melanoma cells.•Fifteen analogs of 2a were synthesized and analyzed for…”
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Restricted distribution of mrg‐1 mRNA in C. elegans primordial germ cells through germ granule‐independent regulation by Miwa, Takashi, Takasaki, Teruaki, Inoue, Kunio, Sakamoto, Hiroshi

“…The chromodomain protein MRG‐1 is an essential maternal factor for proper germline development that protects germ cells from cell death in C. elegans. Unlike…”
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ACAGT-007a, an ERK MAPK Signaling Modulator, in Combination with AKT Signaling Inhibition Induces Apoptosis in KRAS Mutant Pancreatic Cancer T3M4 and MIA-Pa-Ca-2 Cells by Khandakar, Golam Iftakhar, Satoh, Ryosuke, Takasaki, Teruaki, Fujitani, Kana, Tanabe, Genzoh, Sakai, Kazuko, Nishio, Kazuto, Sugiura, Reiko

“…The mitogen-activated protein kinase (MAPK)/ERK and phosphatidylinositol-3 kinase (PI3K)/AKT pathways are dysregulated in various human cancers, including…”
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Trans-generational epigenetic regulation of C. elegans primordial germ cells by Furuhashi, Hirofumi, Takasaki, Teruaki, Rechtsteiner, Andreas, Li, Tengguo, Kimura, Hiroshi, Checchi, Paula M, Strome, Susan, Kelly, William G

“…The processes through which the germline maintains its continuity across generations has long been the focus of biological research. Recent studies have…”
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A genome-wide screen for FTY720-sensitive mutants reveals genes required for ROS homeostasis by Hagihara, Kanako, Kinoshita, Kanako, Ishida, Kouki, Hojo, Shihomi, Kameoka, Yoshinori, Satoh, Ryosuke, Takasaki, Teruaki, Sugiura, Reiko

“…Fingolimod hydrochloride (FTY720), a sphingosine-1-phosphate (S1P) analogue, is an approved immune modulator for the treatment of multiple sclerosis (MS)…”
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MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans by Takasaki, Teruaki, Liu, Zheng, Habara, Yasuaki, Nishiwaki, Kiyoji, Nakayama, Jun-Ichi, Inoue, Kunio, Sakamoto, Hiroshi, Strome, Susan

“…MRG15, a mammalian protein related to the mortality factor MORF4, is required for cell proliferation and embryo survival. Our genetic analysis has revealed…”
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Ellagic Acid Combined with Tacrolimus Showed Synergistic Cell Growth Inhibition in Fission Yeast by HAGIHARA, KANAKO, HOSONAKA, KOUSUKE, HOSHINO, SHUHEI, IWATA, KAZUKI, OGAWA, NAOKI, SATOH, RYOSUKE, TAKASAKI, TERUAKI, MAEDA, TAKUYA, SUGIURA, REIKO

“…Calcineurin (CN) is a conserved Ca2+-calmodulin activated protein phosphatase, which plays important roles in immune regulation, cardiac hypertrophy, and…”
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Arsenite treatment induces Hsp90 aggregatesdistinct from conventional stress granules in fission yeast by Tomimoto, Naofumi, Takasaki, Teruaki, Sugiura, Reiko

“…Various stress conditions, such as heat stress (HS) and oxidative stress, can cause biomolecular condensates represented by stress granules (SGs) via…”
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Rcn1, the fission yeast homolog of human DSCR1, regulates arsenite tolerance independently from calcineurin by Takasaki, Teruaki, Bamba, Asuka, Kukita, Yuka, Nishida, Aiko, Kanbayashi, Daiki, Hagihara, Kanako, Satoh, Ryosuke, Ishihara, Keiichi, Sugiura, Reiko

“…Calcineurin (CN) is a conserved Ca2+/calmodulin‐dependent phosphoprotein phosphatase that plays a key role in Ca2+ signaling. Regulator of calcineurin 1…”
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Distinct Roles of Two Histone Methyltransferases in Transmitting H3K36me3-Based Epigenetic Memory Across Generations in Caenorhabditis elegans by Kreher, Jeremy, Takasaki, Teruaki, Cockrum, Chad, Sidoli, Simone, Garcia, Benjamin A, Jensen, Ole N, Strome, Susan

“…Epigenetic information contributes to proper gene expression and development, and can be transmitted not only through mitotic divisions but also from parents…”
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