Search Results - "TAKANORI, SO"

The immunological significance of tumor necrosis factor receptor-associated factors (TRAFs) by So, Takanori

“…The many roles of TRAFs in immunology Abstract The tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family of molecules are intracellular…”
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Acyl-CoA thioesterase activity of peroxisomal ABC protein ABCD1 is required for the transport of very long-chain acyl-CoA into peroxisomes by Kawaguchi, Kosuke, Mukai, Emi, Watanabe, Shiro, Yamashita, Atsushi, Morita, Masashi, So, Takanori, Imanaka, Tsuneo

“…The ABCD1 protein, one of the four ATP-binding cassette (ABC) proteins in subfamily D, is located on the peroxisomal membrane and is involved in the transport…”
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Detection of Characteristic Phosphatidylcholine Containing Very Long Chain Fatty Acids in Cerebrospinal Fluid from Patients with X-Linked Adrenoleukodystrophy by Fujitani, Naoki, Saito, Masayoshi, Akashi, Tomoya, Morita, Masashi, So, Takanori, Oka, Kozo

“…X-linked Adrenoleukodystrophy (X-ALD) is a rare genetic neurological disorder caused by a mutation of the ABCD1 gene that encodes a peroxisomal ABC protein…”
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The lysosomal protein ABCD4 can transport vitamin B12 across liposomal membranes in vitro by Kitai, Katsuki, Kawaguchi, Kosuke, Tomohiro, Takenori, Morita, Masashi, So, Takanori, Imanaka, Tsuneo

“…Vitamin B12 (cobalamin) is an essential micronutrient for human health, and mutation and dysregulation of cobalamin metabolism are associated with serious…”
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OX40 Ligand-Mannose-Binding Lectin Fusion Protein Induces Potent OX40 Cosignaling in CD4+ T Cells by Sato, Ayaka, Azuma, Mitsuki, Nagai, Hodaka, Imai, Wakana, Kawaguchi, Kosuke, Morita, Masashi, Okuyama, Yuko, Ishii, Naoto, So, Takanori

“…OX40, a member of the tumor necrosis factor (TNF) receptor superfamily, is induced on activated T cells. Membrane-bound OX40 ligand (OX40L) expressed by…”
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Regulation of Interleukin-6 Receptor Signaling by TNF Receptor-Associated Factor 2 and 5 During Differentiation of Inflammatory CD4 + T Cells by Nagashima, Hiroyuki, Ishii, Naoto, So, Takanori

“…There is growing evidence that tumor necrosis factor (TNF) receptor-associated factors (TRAFs) bind to unconventional membrane-bound receptors in many cell…”
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TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development by Nagashima, Hiroyuki, Okuyama, Yuko, Hayashi, Takaya, Ishii, Naoto, So, Takanori

“…IL-17-producing CD4(+) T cells (Th17 cells) regulate host defense and immune pathogenesis, and IL-6 plays an important role for the differentiation of Th17…”
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TNF Receptor-Associated Factor (TRAF) Signaling Network in CD4+ T-Lymphocytes by So, Takanori, Nagashima, Hiroyuki, Ishii, Naoto

“…CD4+ T helper cells (TH cells), such as TH1, TH2, TH17, TFH, and Treg cells, play critical roles in host defense against infection and in the pathogenesis of…”
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TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK–JAK interaction by Kimura, Masanobu, Nagashima, Hiroyuki, Okuyama, Yuko, Ishii, Naoto, So, Takanori

“…TRAF-family members prevent IL-6R-mediated JAK-JAK interaction Abstract Tumor necrosis factor receptor-associated factor 2 (TRAF2) and TRAF5 constitutively…”
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Relationship between the magnitude of IgE production in mice and conformational stability of the house dust mite allergen, Der p 2 by Nakamura, Hitomi, Ohkuri, Takatoshi, So, Takanori, Ueda, Tadashi

“…Protein antigens are degraded by endosomal protease in antigen presentation cell. T cells recognize peptides derived from antigen proteins bound to class II…”
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Role of tumor necrosis factor receptor-associated factor 5 in B- and T-lymphocytes by Hikosaka Kuniishi, Mari, Ishii, Naoto, So, Takanori

“…Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of intracellular signaling adaptors that associate with the cytoplasmic tails of…”
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GITR controls intestinal inflammation by suppressing IL‐15‐dependent NK cell activity by Sakurai, Tsuyoshi, Okuyama, Yuko, Kobayashi, Shuhei, Phung, Hai The, Asao, Atsuko, Kawabe, Takeshi, Ndhlovu, Lishomwa C., Riccardi, Carlo, Kudo, Hironori, Wada, Motoshi, Nio, Masaki, So, Takanori, Ishii, Naoto

“…Glucocorticoid‐induced TNFR family related gene (GITR) is a member of the TNFR superfamily that is expressed on cells of the immune system. Although the…”
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Functional Analysis of the Transcriptional Regulator IκB-ζ in Intestinal Homeostasis by Sasaki, Tomoki, Nagashima, Hiroyuki, Okuma, Atsushi, Yamauchi, Takeshi, Yamasaki, Kenshi, Aiba, Setsuya, So, Takanori, Ishii, Naoto, Owada, Yuji, MaruYama, Takashi, Kobayashi, Shuhei

“…Background The Toll-like receptor signaling pathway contributes to the regulation of intestinal homeostasis through interactions with commensal bacteria…”
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IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s by Tayama, Shunichi, Okuyama, Yuko, Phung, Hai The, Asao, Atsuko, Kobayashi, Shuhei, Musha, Tomomi, Machiyama, Tomoaki, Sakurai, Tsuyoshi, Zhang, Chengming, Ushio-Fukai, Masuko, Kawabe, Takeshi, So, Takanori, Ishii, Naoto

“…Abstract Group 2 innate lymphoid cells (ILC2s) play critical roles in type 2 immunity and are crucial for pathogenesis of various types of inflammatory…”
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TNF Receptor-Associated Factor 5 Limits Function of Plasmacytoid Dendritic Cells by Controlling IFN Regulatory Factor 5 Expression by Kobayashi, Shuhei, Sakurai, Tsuyoshi, So, Takanori, Shiota, Yuka, Asao, Atsuko, Phung, Hai The, Tanaka, Riou, Kawabe, Takeshi, Maruyama, Takashi, Kanno, Emi, Kawakami, Kazuyoshi, Owada, Yuji, Ishii, Naoto

“…The physiological functions of TNF receptor-associated factor 5 (TRAF5) in the skin inflammation and wound healing process are not well characterized. We found…”
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TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation by Machiyama, Tomoaki, So, Takanori, Okuyama, Yuko, Kobayashi, Shuhei, Phung, Hai The, Asao, Atsuko, Harigae, Hideo, Ishii, Naoto

“…Oncostatin M (OSM) is involved in pathogenesis of several human inflammatory diseases including lung inflammation and fibrosis. Although accumulating evidence…”
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Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells by So, Takanori, Soroosh, Pejman, Eun, So-Young, Altman, Amnon, Croft, Michael, Grey, Howard M.

“…NF-κB activation is essential for T-cell responses, and costimulatory molecules in the TNF receptor (TNFR) superfamily are viewed as a major source of this…”
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Biallelic variants/mutations of IL1RAP in patients with steroid-sensitive nephrotic syndrome by Niitsuma, Sou, Kudo, Hiroki, Kikuchi, Atsuo, Hayashi, Takaya, Kumakura, Satoshi, Kobayashi, Shuhei, Okuyama, Yuko, Kumagai, Naonori, Niihori, Tetsuya, Aoki, Yoko, So, Takanori, Funayama, Ryo, Nakayama, Keiko, Shirota, Matsuyuki, Kondo, Shuji, Kagami, Shoji, Tsukaguchi, Hiroyasu, Iijima, Kazumoto, Kure, Shigeo, Ishii, Naoto

“…Abstract Nephrotic syndrome (NS) is a renal disease characterized by severe proteinuria and hypoproteinemia. Although several single-gene mutations have been…”
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Mesenteric lymph nodes contribute to proinflammatory Th17‐cell generation during inflammation of the small intestine in mice by Kawabe, Takeshi, Suzuki, Nobu, Yamaki, Satoshi, Sun, Shu‐lan, Asao, Atsuko, Okuyama, Yuko, So, Takanori, Iwakura, Yoichiro, Ishii, Naoto

“…T cells of the small intestine, including Th17 cells, are critically involved in host protection from microbial infection, and also contribute to the…”
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Signals from OX40 Regulate Nuclear Factor of Activated T Cells C1 and T Cell Helper 2 Lineage Commitment by So, Takanori, Song, Jianxun, Sugie, Katsuji, Altman, Amnon, Croft, Michael

“…T cell helper type 2 (Th2) differentiation is driven by a source of IL-4 receptor (IL-4R) that mobilizes IL-4R signaling pathways and the transcription factor…”
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