Search Results - "TAKANO, Ai"

Visualization and targeting of LGR5+ human colon cancer stem cells by Shimokawa, Mariko, Ohta, Yuki, Nishikori, Shingo, Matano, Mami, Takano, Ai, Fujii, Masayuki, Date, Shoichi, Sugimoto, Shinya, Kanai, Takanori, Sato, Toshiro

“…The cancer stem cell (CSC) theory highlights a self-renewing subpopulation of cancer cells that fuels tumour growth. The existence of human CSCs is mainly…”
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Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition by Fujii, Masayuki, Matano, Mami, Toshimitsu, Kohta, Takano, Ai, Mikami, Yohei, Nishikori, Shingo, Sugimoto, Shinya, Sato, Toshiro

“…Cellular diversity that shapes tissue architecture and function is governed by multiple niche signals. Nonetheless, maintaining cellular diversity in human…”
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Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids by Matano, Mami, Date, Shoichi, Shimokawa, Mariko, Takano, Ai, Fujii, Masayuki, Ohta, Yuki, Watanabe, Toshiaki, Kanai, Takanori, Sato, Toshiro

“…Genome editing applied to human intestinal organoids enables the study of the functional effects of mutations recurrent in human tumors. Human colorectal…”
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A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis by Fujii, Masayuki, Shimokawa, Mariko, Date, Shoichi, Takano, Ai, Matano, Mami, Nanki, Kosaku, Ohta, Yuki, Toshimitsu, Kohta, Nakazato, Yoshihiro, Kawasaki, Kenta, Uraoka, Toshio, Watanabe, Toshiaki, Kanai, Takanori, Sato, Toshiro

“…Colorectal tumor is a heterogeneous disease, with varying clinical presentation and prognosis in patients. To establish a platform encompassing this diversity,…”
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Somatic inflammatory gene mutations in human ulcerative colitis epithelium by Nanki, Kosaku, Fujii, Masayuki, Shimokawa, Mariko, Matano, Mami, Nishikori, Shingo, Date, Shoichi, Takano, Ai, Toshimitsu, Kohta, Ohta, Yuki, Takahashi, Sirirat, Sugimoto, Shinya, Ishimaru, Kazuhiro, Kawasaki, Kenta, Nagai, Yoko, Ishii, Ryota, Yoshida, Kosuke, Sasaki, Nobuo, Hibi, Toshifumi, Ishihara, Soichiro, Kanai, Takanori, Sato, Toshiro

“…With ageing, normal human tissues experience an expansion of somatic clones that carry cancer mutations 1 – 7 . However, whether such clonal expansion exists…”
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Isolation and molecular characterization of Polychromophilus spp. (Haemosporida: Plasmodiidae) from the Asian long-fingered bat (Miniopterus fuliginosus) and Japanese large-footed bat (Myotis macrodactylus) in Japan by Rosyadi, Imron, Shimoda, Hiroshi, Takano, Ai, Yanagida, Tetsuya, Sato, Hiroshi

“…Bats (order, Chiroptera) account for more than one-fifth of all mammalian species in the world and are infected by various intra-erythrocytic parasites of the…”
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Human infections with Borrelia miyamotoi, Japan by Sato, Kozue, Takano, Ai, Konnai, Satoru, Nakao, Minoru, Ito, Takuya, Koyama, Kojiro, Kaneko, Minoru, Ohnishi, Makoto, Kawabata, Hiroki

“…We confirmed infection of 2 patients with Borrelia miyamotoi in Japan by retrospective surveillance of Lyme disease patients and detection of B. miyamotoi DNA…”
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Vitronectin binding protein, BOM1093, confers serum resistance on Borrelia miyamotoi by Sato, Kozue, Kumagai, Yumi, Sekizuka, Tsuyoshi, Kuroda, Makoto, Hayashi, Tetsuya, Takano, Ai, Gaowa, Taylor, Kyle R., Ohnishi, Makoto, Kawabata, Hiroki

“…Borrelia miyamotoi , a member of the tick-borne relapsing fever spirochetes, shows a serum-resistant phenotype in vitro. This ability of B. miyamotoi may…”
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Phylogenic position and low genomic diversity of “Candidatus Rickettsia kotlanii” inferred by complete genome sequences of two Japanese isolates by Gotoh, Yasuhiro, Takano, Ai, Andoh, Masako, Kasama, Kentaro, Nakamura, Keiji, Ando, Shuji, Hayashi, Tetsuya

“…Many Rickettsia species of the spotted fever group (SFG) cause tick‐borne diseases known as “spotted fever.” One of the candidate SFG Rickettsia species is…”
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Fatal Tickborne Phlebovirus Infection in Captive Cheetahs, Japan by Matsuno, Keita, Nonoue, Noriyuki, Noda, Ayako, Kasajima, Nodoka, Noguchi, Keita, Takano, Ai, Shimoda, Hiroshi, Orba, Yasuko, Muramatsu, Mieko, Sakoda, Yoshihiro, Takada, Ayato, Minami, Shinji, Une, Yumi, Morikawa, Shigeru, Maeda, Ken

“…Two captive cheetahs from a zoo in Japan died of a severe fever with thrombocytopenia syndrome-like illness. Severe fever with thrombocytopenia syndrome virus,…”
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Risk assessment of infection with severe fever with thrombocytopenia syndrome virus based on a 10-year serosurveillance in Yamaguchi Prefecture by TATEMOTO, Kango, MENDOZA, Milagros VIRHUEZ, ISHIJIMA, Keita, KURODA, Yudai, INOUE, Yusuke, TAIRA, Masakatsu, KUWATA, Ryusei, TAKANO, Ai, MORIKAWA, Shigeru, SHIMODA, Hiroshi

“…In Japan, the first patient with severe fever with thrombocytopenia syndrome was reported in Yamaguchi in 2012. To understand the severe fever with…”
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Detection of Rickettsia and Ehrlichia spp. in Ticks Associated with Exotic Reptiles and Amphibians Imported into Japan by Andoh, Masako, Sakata, Akiko, Takano, Ai, Kawabata, Hiroki, Fujita, Hiromi, Une, Yumi, Goka, Koichi, Kishimoto, Toshio, Ando, Shuji

“…One of the major routes of transmission of rickettsial and ehrlichial diseases is via ticks that infest numerous host species, including humans. Besides…”
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Description of Ixodes lanigeri sp. nov., a new hard tick species (Acari, Ixodidae) collected from mouse-eared bats (Vespertilionidae, Myotis) in Vietnam by Hornok, Sándor, Kontschán, Jenő, Takano, Ai, Gotoh, Yasuhiro, Hassanin, Alexandre, Tu, Vuong Tan

“…Historically, for more than one and a half centuries, only one so-called “long-legged bat tick” species, i.e., Ixodes vespertilionis Koch was known to science…”
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Epidemiological study of relapsing fever borreliae detected in Haemaphysalis ticks and wild animals in the western part of Japan by Furuno, Kiwa, Lee, Kyunglee, Itoh, Yukie, Suzuki, Kazuo, Yonemitsu, Kenzo, Kuwata, Ryusei, Shimoda, Hiroshi, Watarai, Masahisa, Maeda, Ken, Takano, Ai

“…The genus Borrelia comprises arthropod-borne bacteria, which are infectious agents in vertebrates. They are mainly transmitted by ixodid or argasid ticks. In…”
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Tick surveillance for relapsing fever spirochete Borrelia miyamotoi in Hokkaido, Japan by Takano, Ai, Toyomane, Kochi, Konnai, Satoru, Ohashi, Kazuhiko, Nakao, Minoru, Ito, Takuya, Andoh, Masako, Maeda, Ken, Watarai, Masahisa, Sato, Kozue, Kawabata, Hiroki

“…During 2012-2013, a total of 4325 host-seeking adult ticks belonging to the genus Ixodes were collected from various localities of Hokkaido, the northernmost…”
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Growth Characteristics of Rickettsia Species LON Strains Closely Related to Rickettsia japonica Isolated from Haemaphysalis longicornis Ticks in Mouse Derived L929 and Human-Derived THP-1 Host Cell Lines by Tai, Hitoshi, Su, Hongru, Takamoto, Naoya, Fujita, Hiromi, Takano, Ai, Oishi, Saori, Abe, Fuyuki, Ando, Shuji, Ohashi, Norio

“…Non-pathogenic Rickettsia species LON strains closely related to an agent of Japanese spotted fever (JSF), R. japonica, were isolated in Japan from…”
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Zoonotic Infection with Oz Virus, a Novel Thogotovirus by Tran, Ngo T B, Shimoda, Hiroshi, Ishijima, Keita, Yonemitsu, Kenzo, Minami, Shohei, Kuroda, Yudai, Tatemoto, Kango, Mendoza, Milagros V, Kuwata, Ryusei, Takano, Ai, Muto, Masahiko, Sawabe, Kyoko, Isawa, Haruhiko, Hayasaka, Daisuke, Maeda, Ken

“…Oz virus is a novel thogotovirus isolated from ticks that causes lethal infection in mice. We conducted serosurveillance of Oz virus infection among humans and…”
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Nationwide survey of hepatitis E virus infection among wildlife in Japan by MENDOZA, Milagros Virhuez, YONEMITSU, Kenzo, ISHIJIMA, Keita, KURODA, Yudai, TATEMOTO, Kango, INOUE, Yusuke, SHIMODA, Hiroshi, KUWATA, Ryusei, TAKANO, Ai, SUZUKI, Kazuo, MAEDA, Ken

“…In Japan, hepatitis E virus (HEV) causes hepatitis in humans through the consumption of raw or undercooked meat, including game meat. In the present study,…”
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High conservation combined with high plasticity: genomics and evolution of Borrelia bavariensis by Becker, Noémie S, Rollins, Robert E, Nosenko, Kateryna, Paulus, Alexander, Martin, Samantha, Krebs, Stefan, Takano, Ai, Sato, Kozue, Kovalev, Sergey Y, Kawabata, Hiroki, Fingerle, Volker, Margos, Gabriele

“…Borrelia bavariensis is one of the agents of Lyme Borreliosis (or Lyme disease) in Eurasia. The genome of the Borrelia burgdorferi sensu lato species complex,…”
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Detection and isolation of tick‐borne bacteria (Anaplasma spp., Rickettsia spp., and Borrelia spp.) in Amblyomma varanense ticks on lizard (Varanus salvator) by Supriyono, Takano, Ai, Kuwata, Ryusei, Shimoda, Hiroshi, Hadi, Upik K., Setiyono, Agus, Agungpriyono, Srihadi, Maeda, Ken

“…Ticks are one of the arthropods that play an important role in the transmission of numerous pathogens to livestock and humans. We investigated the presence of…”
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