Search Results - "TAKAMATSU, SHINJI"

Establishment of a novel 70K Mac-2 binding protein antibody through screening of fucosylation-related antibodies by Masuda, Mika, Asuka, Tatsuya, Terao, Naoko, Nishino, Shinsuke, Ikeda, Shun, Takamatsu, Shinji, Kondo, Jumpei, Miyoshi, Eiji

“…Mac-2 binding protein (Mac-2bp) is a serum glycoprotein that contains seven N-glycans, and Mac-2bp serum levels are increased in patients with several types of…”
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Possible involvement of Enterococcus infection in the pathogenesis of chronic pancreatitis and cancer by Maekawa, Tomohiro, Fukaya, Risako, Takamatsu, Shinji, Itoyama, Saki, Fukuoka, Tomoya, Yamada, Makoto, Hata, Tomoki, Nagaoka, Satoshi, Kawamoto, Koichi, Eguchi, Hidetoshi, Murata, Kohei, Kumada, Takashi, Ito, Toshifumi, Tanemura, Masahiro, Fujimoto, Kahoko, Tomita, Yasuhiko, Tobe, Toru, Kamada, Yoshihiro, Miyoshi, Eiji

“…(Aim) Bacterial infection underlies the pathogenesis of many human diseases, including acute and chronic inflammation. Here, we investigated a possible role…”
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Branched-chain amino acids protect the liver from cirrhotic injury via suppression of activation of lipopolysaccharide-binding protein, toll-like receptor 4, and signal transducer and activator of transcription 3, as well as Enterococcus faecalis translocation by Eguchi, Akiko, Iwasa, Motoh, Tamai, Yasuyuki, Tempaku, Mina, Takamatsu, Shinji, Miyoshi, Eiji, Hasegawa, Hiroshi, Kobayashi, Yoshinao, Takei, Yoshiyuki

“…Branched-chain amino acids (BCAAs) are used as nutritional support and for improving prognosis in liver cirrhosis. Here we investigate the molecular mechanisms…”
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Core fucose is essential glycosylation for CD14-dependent Toll-like receptor 4 and Toll-like receptor 2 signalling in macrophages by Nakayama, Kotarosumitomo, Wakamatsu, Kana, Fujii, Hironobu, Shinzaki, Shinichiro, Takamatsu, Shinji, Kitazume, Shinobu, Kamada, Yoshihiro, Takehara, Tetsuo, Taniguchi, Naoyuki, Miyoshi, Eiji

“…Abstract Core fucosylation, catalysed by α-1, 6 fucosyltransferase (FUT8), regulates growth factor receptors in immune function. Although core fucose regulates…”
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Proscillaridin A Sensitizes Human Colon Cancer Cells to TRAIL-Induced Cell Death by Semba, Manami, Takamatsu, Shinji, Komazawa-Sakon, Sachiko, Miyoshi, Eiji, Nishiyama, Chiharu, Nakano, Hiroyasu, Moriwaki, Kenta

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytotoxic cytokine that induces cancer cell death by binding to TRAIL receptors. Because…”
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Identification of the epitope of 10-7G glycan antibody to recognize cancer-associated haptoglobin by Morishita, Koichi, Maki, Yuta, Takamatsu, Shinji, Ito, Nami, Koda, Sayaka, Motooka, Kei, Kamada, Yoshihiro, Kajihara, Yasuhiro, Miyoshi, Eiji

“…We previously identified fucosylated haptoglobin (Fuc-Hpt) as a clinical serum biomarker of pancreatic cancer and established the novel glycan monoclonal…”
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A novel noninvasive diagnostic method for nonalcoholic steatohepatitis using two glycobiomarkers by Kamada, Yoshihiro, Ono, Masafumi, Hyogo, Hideyuki, Fujii, Hideki, Sumida, Yoshio, Mori, Kojiroh, Tanaka, Saiyu, Yamada, Makoto, Akita, Maaya, Mizutani, Kayo, Fujii, Hironobu, Yamamoto, Akiko, Takamatsu, Shinji, Yoshida, Yuichi, Itoh, Yoshito, Kawada, Norifumi, Chayama, Kazuaki, Saibara, Toshiji, Takehara, Tetsuo, Miyoshi, Eiji

“…Nonalcoholic fatty liver disease (NAFLD) is a growing medical problem; thus, discriminating nonalcoholic steatohepatitis (NASH) from NAFLD is of great clinical…”
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The specific core fucose-binding lectin Pholiota squarrosa lectin (PhoSL) inhibits hepatitis B virus infection in vitro by Ouchida, Tsunenori, Maeda, Haruka, Akamatsu, Yuka, Maeda, Megumi, Takamatsu, Shinji, Kondo, Jumpei, Misaki, Ryo, Kamada, Yoshihiro, Ueda, Masahiro, Ueda, Keiji, Miyoshi, Eiji

“…Glycosylation of proteins and lipids in viruses and their host cells is important for viral infection and is a target for antiviral therapy. Hepatitis B virus…”
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Identification of fucosylated haptoglobin‐producing cells in pancreatic cancer tissue and its molecular mechanism by Ito, Nami, Yamada, Momoko, Morishita, Koichi, Nojima, Satoshi, Motooka, Kei, Sakata, Natsumi, Asuka, Tatsuya, Otsu, Ryoji, Takamatsu, Shinji, Kamada, Yoshihiro, Mori, Soichiro, Akita, Hirofumi, Eguchi, Hidetoshi, Morii, Eiichi, Miyoshi, Eiji

“…Fucosylated haptoglobin is a well-established glyco-biomarker of pancreatic cancer. We recently established a novel anti-glycan antibody (10-7G mAb) that…”
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Glyco-redox, a link between oxidative stress and changes of glycans: Lessons from research on glutathione, reactive oxygen and nitrogen species to glycobiology by Taniguchi, Naoyuki, Kizuka, Yasuhiko, Takamatsu, Shinji, Miyoshi, Eiji, Gao, Congxiao, Suzuki, Keiichiro, Kitazume, Shinobu, Ohtsubo, Kazuaki

“…Reduction–oxidation (redox) response is one of the most important biological phenomena. The concept introduced by Helmut Sies encouraged many researchers to…”
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Lewis glycosphingolipids as critical determinants of TRAIL sensitivity in cancer cells by Fukuoka, Tomoya, Moriwaki, Kenta, Takamatsu, Shinji, Kondo, Jumpei, Tanaka-Okamoto, Miki, Tomioka, Azusa, Semba, Manami, Komazawa-Sakon, Sachiko, Kamada, Yoshihiro, Kaji, Hiroyuki, Miyamoto, Yasuhide, Inoue, Masahiro, Bessho, Kazuhiko, Miyoshi, Yoko, Ozono, Keiichi, Nakano, Hiroyasu, Miyoshi, Eiji

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces cancer cell death and contributes to tumor rejection by cytotoxic lymphocytes in cancer…”
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Dietary and Genetic Control of Glucose Transporter 2 Glycosylation Promotes Insulin Secretion in Suppressing Diabetes by Ohtsubo, Kazuaki, Takamatsu, Shinji, Minowa, Mari T., Yoshida, Aruto, Takeuchi, Makoto, Marth, Jamey D.

“…Pancreatic β cell-surface expression of glucose transporter 2 (Glut-2) is essential for glucose-stimulated insulin secretion, thereby controlling blood glucose…”
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Haptoglobin phenotype is a critical factor in the use of fucosylated haptoglobin for pancreatic cancer diagnosis by Morishita, Koichi, Ito, Nami, Koda, Sayaka, Maeda, Megumi, Nakayama, Kotarosumitomo, Yoshida, Kiyoshi, Takamatsu, Shinji, Yamada, Makoto, Eguchi, Hidetoshi, Kamada, Yoshihiro, Miyoshi, Eiji

“…Fucosylation is one of the most important glycosylations involved in cancer and inflammation. Many studies have reported significant increases in serum…”
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Fucosylation is a common glycosylation type in pancreatic cancer stem cell-like phenotypes by Terao, Naoko, Takamatsu, Shinji, Minehira, Tomomi, Sobajima, Tomoaki, Nakayama, Kotarosumitomo, Kamada, Yoshihiro, Miyoshi, Eiji

“…AIM: To evaluate/isolate cancer stem cells(CSCs) from tissue or cell lines according to various definitions and cell surface markers. METHODS: Lectin…”
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Vesicular Integral-Membrane Protein 36 Is Involved in the Selective Secretion of Fucosylated Proteins into Bile Duct-like Structures in HepG2 Cells by Muranaka, Mizuki, Takamatsu, Shinji, Ouchida, Tsunenori, Kanazawa, Yuri, Kondo, Jumpei, Nakagawa, Tsutomu, Egashira, Yuriko, Fukagawa, Koji, Gu, Jianguo, Okamoto, Toru, Kamada, Yoshihiro, Miyoshi, Eiji

“…Fucosylated proteins are widely used as biomarkers of cancer and inflammation. Fucosylated alpha-fetoprotein (AFP-L3) is a specific biomarker for…”
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N-glycosylation modulates the membrane sub-domain distribution and activity of glucose transporter 2 in pancreatic beta cells by Ohtsubo, Kazuaki, Takamatsu, Shinji, Gao, Congxiao, Korekane, Hiroaki, Kurosawa, Tsutomu M., Taniguchi, Naoyuki

“…•Dysglycosylation induced membrane redistribution of GLUT2 to lipid-raft microdomain.•Binding of GLUT2 N-glycan to galectin9 sustains non-raft microdomain…”
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Serum fucosylated haptoglobin as a novel prognostic biomarker predicting high-Gleason prostate cancer by Fujita, Kazutoshi, Shimomura, Mayuka, Uemura, Motohide, Nakata, Wataru, Sato, Mototaka, Nagahara, Akira, Nakai, Yasutomo, Takamatsu, Shinji, Miyoshi, Eiji, Nonomura, Norio

“…BACKGROUND Fucosylation is an oligosaccharide modification associated with cancer and inflammation, which is catalyzed by fucosyltransferases. Fucosylated…”
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A glycoproteomic approach to identify novel glycomarkers for cancer stem cells by Sawanobori, Atsuko, Moriwaki, Kenta, Takamatsu, Shinji, Kamada, Yoshihiro, Miyoshi, Eiji

“…Most cancers consist of heterogeneous populations of cells with substantial differences in tumorigenicity. Cells that possess self‐renewal and tumor‐initiating…”
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Detection of fucosylated haptoglobin using the 10-7G antibody as a biomarker for evaluating endoscopic remission in ulcerative colitis by Motooka, Kei, Morishita, Koichi, Ito, Nami, Shinzaki, Shinichiro, Tashiro, Taku, Nojima, Satoshi, Shimizu, Kayoko, Date, Mutsuhiro, Sakata, Natsumi, Yamada, Momoko, Takamatsu, Shinji, Kamada, Yoshihiro, Iijima, Hideki, Mizushima, Tsunekazu, Morii, Eiichi, Takehara, Tetsuo, Miyoshi, Eiji

“…Inflammatory bowel disease (IBD) is a chronic, relapsing inflammation of the digestive tract. Although fecal and serum biomarkers have been extremely important…”
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Loss of core fucosylation reduces low-density lipoprotein receptor expression in hepatocytes by inducing PCSK9 production by Kamada, Yoshihiro, Yamamoto, Akiko, Fujiyoshi, Anna, Koseki, Masahiro, Morishita, Koichi, Asuka, Tatsuya, Takamatsu, Shinji, Sakata, Yasushi, Takehara, Tetsuo, Taniguchi, Naoyuki, Miyoshi, Eiji

“…Fucosylation is a type of glycosylation, a form of post-transcriptional regulation of proteins, involved in cancer and inflammation. It involves the attachment…”
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