Search Results - "TAKAKI, MIYAKO"

Gut Pacemaker Cells: the Interstitial Cells of Cajal (ICC) by Takaki, Miyako

“…This review will focus on the pacemaker mechanisms underlying gastrointestinal autonomic rhythmicity in an attempt to elucidate the differences and…”
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Mechanism underlying the negative inotropic effect in rat left ventricle in hyperthermia: the role of TRPV1 by Obata, Koji, Morita, Hironobu, Takaki, Miyako

“…We have previously reported that the negative inotropic effects of hyperthermia (42 °C) on left ventricular (LV) mechanoenergetics using the excised,…”
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Left ventricular mechanoenergetics in excised, cross-circulated rat hearts under hypo-, normo-, and hyperthermic conditions by Obata, Koji, Takeshita, Daisuke, Morita, Hironobu, Takaki, Miyako

“…We investigated the effects of altering cardiac temperature on left ventricular (LV) myocardial mechanical work and energetics using the excised,…”
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Confocal and multiphoton calcium imaging of the enteric nervous system in anesthetized mice by Motegi, Yuki, Sato, Masaaki, Horiguchi, Kazuhide, Ohkura, Masamichi, Gengyo-Ando, Keiko, Ikegaya, Yuji, Fusamae, Yasuyuki, Hongo, Yoshie, Suzuki, Minoru, Ogawa, Koichi, Takaki, Miyako, Nakai, Junichi

“…•New transgenic mice co-express G-CaMP6 and mCherry in ENS neurons.•Intestinal movement stabilization by suction enables imaging of ENS activity in living…”
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Activation of 5-HT4 receptors facilitates neurogenesis from transplanted neural stem cells in the anastomotic ileum by Goto, Kei, Kawahara, Isao, Inada, Hiroyuki, Misawa, Hiromi, Kuniyasu, Hiroki, Nabekura, Junich, Takaki, Miyako

“…An orally administered serotonin-4 (5-HT4) receptor agonist, mosapride citrate (MOS), promotes enteric neurogenesis in anastomoses after gut surgery. We…”
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Left ventricular mechanical and energetic changes in long-term isoproterenol-induced hypertrophied hearts of SERCA2a transgenic rats by Mitsuyama, Shinichi, Takeshita, Daisuke, Obata, Koji, Zhang, Guo-Xing, Takaki, Miyako

“…Abstract Overexpression of cardiac sarcoplasmic reticulum Ca 2 + -ATPase (SERCA2a) has been suggested as a strategic intervention for cardiac failure. However,…”
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In vivo imaging of enteric neurogenesis in the deep tissue of mouse small intestine by Goto, Kei, Kato, Go, Kawahara, Isao, Luo, Yi, Obata, Koji, Misawa, Hiromi, Ishikawa, Tatsuya, Kuniyasu, Hiroki, Nabekura, Junich, Takaki, Miyako

“…One of the challenges of using imaging techniques as a tool to study cellular physiology has been the inability to resolve structures that are not located near…”
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A protein tyrosine kinase receptor, c-RET signaling pathway contributes to the enteric neurogenesis induced by a 5-HT4 receptor agonist at an anastomosis after transection of the gut in rodents by Goto, Kei, Kawahara, Isao, Kuniyasu, Hiroki, Takaki, Miyako

“…We previously reported that a serotonin 4 (5-HT4) receptor agonist, mosapride citrate (MOS), increased the number of c-RET-positive cells and levels of c-RET…”
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Age-related changes in afferent responses in sensory neurons to mechanical stimulation of osteoblasts in coculture system by Asada, Keiji, Obata, Koji, Horiguchi, Kazuhide, Takaki, Miyako

“…Bone homeostasis is regulated by mechanical stimulation (MS). The sensory mechanism of bone tissue for MS remains unknown in the maintenance of bone…”
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Activation of 5-HT4 receptors facilitates neurogenesis of injured enteric neurons at an anastomosis in the lower gut by Takaki, Miyako, Goto, Kei, Kawahara, Isao, Nabekura, Junich

“…Two-photon microscopy (2PM) can enable high-resolution deep imaging of thick tissue by exciting a fluorescent dye and protein at anastomotic sites in the mouse…”
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The 5-hydroxytryptamine 4 Receptor Agonist-induced Actions and Enteric Neurogenesis in the Gut by Takaki, Miyako, Goto, Kei, Kawahara, Isao

“…We explored a novel effect of 5-hydroxytryptamine 4 receptor (5-HT4R) agonists in vivo to reconstruct the enteric neural circuitry that mediates a fundamental…”
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Increased Passive Stiffness of Cardiomyocytes in the Transverse Direction and Residual Actin and Myosin Cross-Bridge Formation in Hypertrophied Rat Hearts Induced by Chronic β-Adrenergic Stimulation by Yoshikawa, Wakako Sumita, Nakamura, Kazufumi, Miura, Daiji, Shimizu, Juichiro, Hashimoto, Ken, Kataoka, Noriyuki, Toyota, Hiroko, Okuyama, Hiroshi, Miyoshi, Toru, Morita, Hiroshi, Kusano, Kengo Fukushima, Matsuo, Tatsuhito, Takaki, Miyako, Kajiya, Fumihiko, Yagi, Naoto, Ohe, Tohru, Ito, Hiroshi

“…Background: Left ventricular (LV) hypertrophy is often present in patients with diastolic heart failure. However, stiffness of hypertrophied cardiomyocytes in…”
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In Vitro Formation of Enteric Neural Network Structure in a Gut‐Like Organ Differentiated from Mouse Embryonic Stem Cells by Takaki, Miyako, Nakayama, Shinsuke, Misawa, Hiromi, Nakagawa, Tadashi, Kuniyasu, Hiroki

“…Using an embryoid body (EB) culture system, we developed a functional organ‐like cluster—a “gut”—from mouse embryonic stem (ES) cells (ES gut). Each ES gut…”
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Characterizations of the α1-adrenoceptor subtypes mediating contractions of the human internal anal sphincter by Owaki, Hiroyuki, Sadahiro, Sotaro, Takaki, Miyako

“…Human internal anal sphincter (IAS) is contracted by α1-adrenoceptor stimulation and thus α1-adrenoceptor agonists may be useful in treating fecal…”
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NHE-1 participates in isoproterenol-induced downregulation of SERCA2a and development of cardiac remodeling in rat hearts by Shibata, Munetaka, Takeshita, Daisuke, Obata, Koji, Mitsuyama, Shinichi, Ito, Haruo, Zhang, Guo-Xing, Takaki, Miyako

“…Impaired Ca(2+) handling is one of the main characteristics in heart failure patients. Recently, we reported abnormal expressions of Ca(2+)-handling proteins…”
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Comparison of effects of a selective 5-HT reuptake inhibitor versus a 5-HT4 receptor agonist on in vivo neurogenesis at the rectal anastomosis in rats by Kawahara, Isao, Kuniyasu, Hiroki, Matsuyoshi, Hiroko, Goto, Kei, Obata, Koji, Misawa, Hiromi, Fujii, Hisao, Takaki, Miyako

“…It was recently reported that activation of enteric neural 5-HT(4) receptors (SR4) promotes reconstruction of enteric neural circuit injury in distal gut of…”
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Cardioprotective effects of a novel calpain inhibitor SNJ-1945 for reperfusion injury after cardioplegic cardiac arrest by Yoshikawa, Yoshiro, Zhang, Guo-Xing, Obata, Koji, Ohga, Yoshimi, Matsuyoshi, Hiroko, Taniguchi, Shigeki, Takaki, Miyako

“…We have previously indicated that calpain inhibitor-1 prevents the heart from ischemia- reperfusion injury associated with the impairment of total Ca(2+)…”
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Effects of Angiotensin Type I Receptor Blockade on the Cardiac Raf/MEK/ERK Cascade Activated via Adrenergic Receptors by Zhang, Guo-Xing, Kimura, Shoji, Murao, Koji, Yu, Xiao, Obata, Koji, Matsuyoshi, Hiroko, Takaki, Miyako

“…A close interaction between adrenergic nerves and angiotensin systems has been documented. The present study was designed to investigate the mechanisms of…”
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In vitro enhanced differentiation of neural networks in ES gut-like organ from mouse ES cells by a 5-HT4-receptor activation by Takaki, Miyako, Misawa, Hiromi, Matsuyoshi, Hiroko, Kawahara, Isao, Goto, Kei, Zhang, Guo-Xing, Obata, Koji, Kuniyasu, Hiroki

“…Using an embryoid body (EB) culture system, we developed a functional organ-like cluster, a "gut", from mouse embryonic stem (ES) cells (ES gut). Each ES gut…”
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Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat model by Sakata, Susumu, Lebeche, Djamel, Sakata, Yuri, Sakata, Naoya, Chemaly, Elie R, Liang, Lifan, Nakajima-Takenaka, Chikako, Tsuji, Tsuyoshi, Konishi, Noboru, del Monte, Federica, Hajjar, Roger J, Takaki, Miyako

“…The Otsuka Long-Evans Tokushima fatty rat is an animal model of Type 2 diabetes mellitus (DM), which is characterized by diastolic dysfunction associated with…”
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