Search Results - "TAKAI, Akira"
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Expanded palette of Nano-lanterns for real-time multicolor luminescence imaging
Published in Proceedings of the National Academy of Sciences - PNAS (07-04-2015)“…Fluorescence live imaging has become an essential methodology in modern cell biology. However, fluorescence requires excitation light, which can sometimes…”
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The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy
Published in Molecular cell (15-06-2023)“…Mitophagy plays an important role in mitochondrial homeostasis by selective degradation of mitochondria. During mitophagy, mitochondria should be fragmented to…”
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3
High hydrostatic pressure induces slow contraction in mouse cardiomyocytes
Published in Biophysical journal (03-01-2023)Get full text
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Addition of urea and thiourea to electrophoresis sample buffer improves efficiency of protein extraction from TCA/acetone‐treated smooth muscle tissues for phos‐tag SDS‐PAGE
Published in Electrophoresis (01-01-2018)“…Phosphorylation analysis by using phos‐tag technique has been reported to be suitable for highly sensitive quantification of smooth muscle myosin regulatory…”
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MicroRNAs as Potential Mediators for Cigarette Smoking Induced Atherosclerosis
Published in International journal of molecular sciences (06-04-2018)“…Smoking increases the risk of atherosclerosis-related events, such as myocardial infarction and ischemic stroke. Recent studies have examined the expression…”
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Protein phosphatases 1 and 2A and their naturally occurring inhibitors: current topics in smooth muscle physiology and chemical biology
Published in The journal of physiological sciences (01-01-2018)“…Protein phosphatases 1 and 2A (PP1 and PP2A) are the most ubiquitous and abundant serine/threonine phosphatases in eukaryotic cells. They play fundamental…”
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Elephant’s breast milk contains large amounts of glucosamine
Published in Journal of Veterinary Medical Science (2017)“…Hand-reared elephant calves that are nursed with milk substitutes sometimes suffer bone fractures, probably due to problems associated with nutrition,…”
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Essential role of Dkk3 for head formation by inhibiting Wnt/β-catenin and Nodal/Vg1 signaling pathways in the basal chordate amphioxus
Published in Evolution & development (01-07-2012)“…SUMMARY To dissect the molecular mechanism of head specification in the basal chordate amphioxus, we investigated the function of Dkk3, a secreted protein in…”
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Force-inhibiting effect of Ser/Thr protein phosphatase 2A inhibitors on bovine ciliary muscle
Published in Journal of Smooth Muscle Research (2015)“…Ciliary muscle is a smooth muscle characterized by a rapid response to muscarinic receptor stimulation and sustained contraction. Although it is evident that…”
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Urinary sex steroid hormone and placental leucine aminopeptidase concentration differences between live births and stillbirth of Bornean orangutans (Pongo pygmaeus)
Published in Journal of medical primatology (01-02-2017)“…Background Under the environment of pregnancy, the placenta assumes an important steroidogenic role in the maintenance of pregnancy. Methods Urinary placental…”
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Crystal Structure of the Complex between Calyculin A and the Catalytic Subunit of Protein Phosphatase 1
Published in Structure (London) (01-05-2002)“…The crystal structure of the catalytic subunit of the protein phosphatase 1 (PP1), PP1γ, in complex with a marine toxin, calyculin A, was determined at 2.0 Å…”
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Protein phosphatase inhibitory activity of tautomycin photoaffinity probes evaluated at femto-molar level
Published in Bioorganic & medicinal chemistry (15-02-2008)“…Development of a highly sensitive firefly bioluminescence assay system was, in fact, applied to ten tautomycin analogs having photoaffinity probes to obtain…”
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13
Effects of specific modifications of several hydroxyls of tetrodotoxin on its affinity to rat brain membrane
Published in The Journal of pharmacology and experimental therapeutics (01-06-1999)“…The widely used sodium channel blocker tetrodotoxin (TTX) is a compound that has six hydroxyl residues at the C-4, C-6, C-8, C-9, C-10, and C-11 positions in…”
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Two types of non-selective cation channel opened by muscarinic stimulation with carbachol in bovine ciliary muscle cells
Published in The Journal of physiology (15-09-2004)“…In the ciliary muscle, the tonic contraction requires a sustained influx of Ca 2+ through the cell membrane. However, little has hitherto been known about the…”
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Cranial cartilages: Players in the evolution of the cranium during evolution of the chordates in general and of the vertebrates in particular
Published in Evolution & development (01-05-2023)“…The present contribution is chiefly a review, augmented by some new results on amphioxus and lamprey anatomy, that draws on paleontological and developmental…”
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Role of TRPC6 on Single Cell Mechanics in Mouse Cardiomyocytes
Published in Biophysical journal (07-02-2020)Get full text
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High hydrostatic pressure induces slow contraction in mouse cardiomyocytes
Published in Biophysical journal (06-09-2022)“…Cardiomyocytes are contractile cells that regulate heart contraction. Ca2+ flux via Ca2+ channels activates actomyosin interactions, leading to cardiomyocyte…”
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Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin
Published in FEBS letters (08-06-1987)“…Smooth muscle contraction depends on the state of myosin phosphorylation and hence on the balance of myosin light chain kinase and phosphatase activity…”
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Phosphorylated retinoblastoma protein stimulates DNA polymerase α
Published in Oncogene (13-11-1997)“…Human retinoblastoma (Rb) protein, immunopurified from an extract of recombinant baculovirus infected cells, stimulated 10-100-fold the activity of DNA…”
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Molecular shape analysis and activity of tautomycin, a protein phosphatase inhibitor
Published in Bioorganic & medicinal chemistry letters (01-01-1996)“…Tautomycin, a well-known protein phosphatase inhibitor, exists in two forms (acid anhydride and diacid). We successfully isolated them and proved that diacid…”
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