Search Results - "TAKAHASHI, Toshitada"

Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells by Akazawa, Takashi, Ebihara, Takashi, Okuno, Manabu, Okuda, Yu, Shingai, Masashi, Tsujimura, Kunio, Takahashi, Toshitada, Ikawa, Masahito, Okabe, Masaru, Inoue, Norimitsu, Okamoto-Tanaka, Miki, Ishizaki, Hiroyoshi, Miyoshi, Jun, Matsumoto, Misako, Seya, Tsukasa

“…Myeloid dendritic cells (mDCs) recognize and respond to polyI:C, an analog of dsRNA, by endosomal Toll-like receptor (TLR) 3 and cytoplasmic receptors. Natural…”
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Minor histocompatibility antigens as targets for immunotherapy using allogeneic immune reactions by Akatsuka, Yoshiki, Morishima, Yasuo, Kuzushima, Kiyotaka, Kodera, Yoshihisa, Takahashi, Toshitada

“…Minor histocompatibility antigens (mHag) were originally identified as antigens causing graft rejection or graft‐versus‐host disease in human leukocyte antigen…”
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Autophosphorylation of a Newly Identified Site of Aurora-B Is Indispensable for Cytokinesis by Yasui, Yoshihiro, Urano, Takeshi, Kawajiri, Aie, Nagata, Koh-ichi, Tatsuka, Masaaki, Saya, Hideyuki, Furukawa, Koichi, Takahashi, Toshitada, Izawa, Ichiro, Inagaki, Masaki

“…Mitotic kinases regulate cell division and its checkpoints, errors of which can lead to aneuploidy or genetic instability. One of these is Aurora-B, a key…”
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Alternative splicing due to an intronic SNP in HMSD generates a novel minor histocompatibility antigen by Kawase, Takakazu, Akatsuka, Yoshiki, Torikai, Hiroki, Morishima, Satoko, Oka, Akira, Tsujimura, Akane, Miyazaki, Mikinori, Tsujimura, Kunio, Miyamura, Koichi, Ogawa, Seishi, Inoko, Hidetoshi, Morishima, Yasuo, Kodera, Yoshihisa, Kuzushima, Kiyotaka, Takahashi, Toshitada

“…Here we report the identification of a novel human leukocyte antigen (HLA)-B44–restricted minor histocompatibility antigen (mHA) with expression limited to…”
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CD137-guided isolation and expansion of antigen-specific CD8 cells for potential use in adoptive immunotherapy by Watanabe, Kazue, Suzuki, Susumu, Kamei, Michi, Toji, Shingo, Kawase, Takakazu, Takahashi, Toshitada, Kuzushima, Kiyotaka, Akatsuka, Yoshiki

“…The efficient isolation and ex vivo expansion of antigen-specific T cells are crucial for successful adoptive immunotherapy against uncontrollable infections…”
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Gene expression-based, individualized outcome prediction for surgically treated lung cancer patients by TOMIDA, Shuta, KOSHIKAWA, Katsumi, TAKAHASHI, Takashi, YATABE, Yasushi, HARANO, Tomoko, OGURA, Nobuhiko, MITSUDOMI, Tetsuya, SOME, Masato, YANAGISAWA, Kiyoshi, TAKAHASHI, Toshitada, OSADA, Hirotaka

“…Individualized outcome prediction classifiers were successfully constructed through expression profiling of a total of 8644 genes in 50 non-small-cell lung…”
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Identification of a Novel Phosphorylation Site on Histone H3 Coupled with Mitotic Chromosome Condensation by Goto, Hidemasa, Kosako, Hidetaka, Tomono, Yasuko, Ajiro, Kozo, Fujita, Masatoshi, Sakurai, Minoru, Okawa, Katsuya, Iwamatsu, Akihiro, Okigaki, Tohru, Takahashi, Toshitada, Inagaki, Masaki

“…Histone H3 (H3) phosphorylation at Ser10 occurs during mitosis in eukaryotes and was recently shown to play an important role in chromosome condensation in…”
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The CC Chemokine Receptor 4 as a Novel Specific Molecular Target for Immunotherapy in Adult T-Cell Leukemia/Lymphoma by ISHIDA, Takashi, IIDA, Shinsuke, AKINAGA, Shiro, TAKAHASHI, Toshitada, UTSUNOMIYA, Atae, UEDA, Ryuzo, AKATSUKA, Yoshiki, ISHII, Toshihiko, MIYAZAKI, Mikinori, KOMATSU, Hirokazu, INAGAKI, Hiroshi, OKADA, Noriko, FUJITA, Teizo, SHITARA, Kenya

“…Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell neoplasm with dismal prognosis, and no optimal therapy has been developed. We tested the…”
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HapMap scanning of novel human minor histocompatibility antigens by Kamei, Michi, Nannya, Yasuhito, Torikai, Hiroki, Kawase, Takakazu, Taura, Kenjiro, Inamoto, Yoshihiro, Takahashi, Taro, Yazaki, Makoto, Morishima, Satoko, Tsujimura, Kunio, Miyamura, Koichi, Ito, Tetsuya, Togari, Hajime, Riddell, Stanley R., Kodera, Yoshihisa, Morishima, Yasuo, Takahashi, Toshitada, Kuzushima, Kiyotaka, Ogawa, Seishi, Akatsuka, Yoshiki

“…Minor histocompatibility antigens (mHags) are molecular targets of allo-immunity associated with hematopoietic stem cell transplantation (HSCT) and involved in…”
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Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens by Akatsuka, Yoshiki, Nishida, Tetsuya, Kondo, Eisei, Miyazaki, Mikinori, Taji, Hirohumi, Iida, Hiroatsu, Tsujimura, Kunio, Yazaki, Makoto, Naoe, Tomoki, Morishima, Yasuo, Kodera, Yoshihisa, Kuzushima, Kiyotaka, Takahashi, Toshitada

“…We report the identification of two novel minor histocompatibility antigens (mHAgs), encoded by two separate single nucleotide polymorphisms on a single gene,…”
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Epstein–Barr virus nuclear antigen 1‐specific CD4+ T cells directly kill Epstein–Barr virus‐carrying natural killer and T cells by Demachi‐Okamura, Ayako, Ito, Yoshinori, Akatsuka, Yoshiki, Tsujimura, Kunio, Morishima, Yasuo, Takahashi, Toshitada, Kuzushima, Kiyotaka

“…Epstein–Barr virus (EBV) nuclear antigen (EBNA)1 is expressed in every EBV‐infected cell, regardless of the state of EBV infection. Although EBNA1 is thought…”
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Adjuvant-mediated tumor regression and tumor-specific cytotoxic response are impaired in MyD88-deficient mice by AKAZAWA, Takashi, MASUDA, Hisayo, TOYOSHIMA, Kumao, SEYA, Tsukasa, SAEKI, Yoshiko, MATSUMOTO, Misako, TAKEDA, Kiyoshi, TSUJIMURA, Kunio, KUZUSHIMA, Kiyotaka, TAKAHASHI, Toshitada, AZUMA, Ichiro, AKIRA, Shizuo

“…The Mycobacterium bovis bacillus Calmette-Guérin cell-wall skeleton (BCG-CWS) activates Toll-like receptor (TLR) 2 and TLR4, but unlike the typical TLR4…”
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Absence of Tumor Necrosis Factor Rescues RelA-Deficient Mice from Embryonic Lethality by Doi, Takahiro S., Marino, Michael W., Takahashi, Toshitada, Yoshida, Toshimichi, Sakakura, Teruyo, Old, Lloyd J., Obata, Yuichi

“…Mice lacking the RelA (p65) subunit of NF-κ B die between days 14 and 15 of embryogenesis because of massive liver destruction. Fibroblasts and macrophages…”
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Identification of novel CTL epitopes of CMV-pp65 presented by a variety of HLA alleles by Kondo, Eisei, Akatsuka, Yoshiki, Kuzushima, Kiyotaka, Tsujimura, Kunio, Asakura, Shoji, Tajima, Kohei, Kagami, Yoshitoyo, Kodera, Yoshihisa, Tanimoto, Mitsune, Morishima, Yasuo, Takahashi, Toshitada

“…Cytomegalovirus (CMV)–specific T-cell immunity plays an important role in protection from CMV disease in immunocompromised patients. Identification of…”
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Mismatched human leukocyte antigen class II‐restricted CD8+ cytotoxic T cells may mediate selective graft‐versus‐leukemia effects following allogeneic hematopoietic cell transplantation by Hirosawa, Tomoya, Torikai, Hiroki, Yanagisawa, Mayumi, Kamei, Michi, Imahashi, Nobuhiko, Demachi‐Okamura, Ayako, Tanimoto, Miyoko, Shiraishi, Keiko, Ito, Mamoru, Miyamura, Koichi, Shibata, Kiyosumi, Kikkawa, Fumitaka, Morishima, Yasuo, Takahashi, Toshitada, Emi, Nobuhiko, Kuzushima, Kiyotaka, Akatsuka, Yoshiki

“…Partial human leukocyte antigen (HLA)‐mismatched hematopoietic stem cell transplantation (HSCT) is often performed when an HLA‐matched donor is not available…”
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Behavior of Bone Marrow–Derived Cells Following in Vivo Transplantation by Taguchi, Osamu, Tsujimura, Kunio, Kontani, Keiichi, Harada, Yosuke, Nomura, Sachiyo, Ikeda, Hiroshi, Morita, Akimichi, Sugiura, Hideshi, Hayashi, Norio, Yatabe, Yasushi, Seto, Masao, Tatematsu, Masae, Takahashi, Toshitada, Fukushima, Atsuki

“…After injection of green fluorescent protein–positive (GFP+ ) bone marrow (BM) cells into lethally irradiated wild-type mice, the organs of the recipient mice…”
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Expression of cancer/testis (CT) antigens in lung cancer by Tajima, Kouhei, Obata, Yuichi, Tamaki, Hiromi, Yoshida, Masahiro, Chen, Yao-Tseng, Scanlan, Matthew J, Old, Lloyd J, Kuwano, Hiroyuki, Takahashi, Takashi, Takahashi, Toshitada, Mitsudomi, Tetsuya

“…Cancer/testis (CT) antigens are considered promising candidates for vaccine-based immunotherapy. The aim of this study was to investigate which CT antigens…”
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Significant Growth Inhibition of Human Lung Cancer Cells Both in Vitro and in Vivo by the Combined Use of a Selective Cyclooxygenase 2 Inhibitor, JTE-522, and Conventional Anticancer Agents by HIDA, Toyoaki, KOZAKI, Ken-Ichi, TAKAHASHI, Takashi, ITO, Hidemi, MIYAISHI, Osamu, TATEMATSU, Yoshio, SUZUKI, Takeshi, MATSUO, Keitaro, SUGIURA, Takahiko, OGAWA, Makoto, TAKAHASHI, Toshitada

“…This study reports that a selective COX-2 inhibitor JTE-522inhibits both in vitro and in vivo growth of human lung cancer cells as a single agent. Furthermore,…”
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Aberrant expression of BCL2A1-restricted minor histocompatibility antigens in melanoma cells: application for allogeneic transplantation by Torikai, Hiroki, Akatsuka, Yoshiki, Yatabe, Yasushi, Morishima, Yasuo, Kodera, Yoshihisa, Kuzushima, Kiyotaka, Takahashi, Toshitada

“…It has been shown that allogeneic hematopoietic stem cell transplantation (HSCT) can be one of the therapeutic options for patients with metastatic solid…”
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A Novel HLA-A3303-Restricted Minor Histocompatibility Antigen Encoded by an Unconventional Open Reading Frame of Human TMSB4Y Gene by Torikai, Hiroki, Akatsuka, Yoshiki, Miyazaki, Mikinori, Warren, Edus H., III, Oba, Taku, Tsujimura, Kunio, Motoyoshi, Kazuo, Morishima, Yasuo, Kodera, Yoshihisa, Kuzushima, Kiyotaka, Takahashi, Toshitada

“…Female-to-male hemopoietic stem cell transplantation (HSCT) elicits T cell responses against male-specific minor histocompatibility (H-Y) Ags encoded by the Y…”
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