Search Results - "TAKAHASHI, Tatsuro"

Reconstitution of mitotic chromatids with a minimum set of purified factors by Shintomi, Keishi, Takahashi, Tatsuro S., Hirano, Tatsuya

“…The assembly of mitotic chromosomes, each composed of a pair of rod-shaped chromatids, is an essential prerequisite for accurate transmission of the genome…”
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Resection of DNA double-strand breaks activates Mre11-Rad50-Nbs1- and Rad9-Hus1-Rad1-dependent mechanisms that redundantly promote ATR checkpoint activation and end processing in Xenopus egg extracts by Tatsukawa, Kensuke, Sakamoto, Reihi, Kawasoe, Yoshitaka, Kubota, Yumiko, Tsurimoto, Toshiki, Takahashi, Tatsuro S, Ohashi, Eiji

“…Sensing and processing of DNA double-strand breaks (DSBs) are vital to genome stability. DSBs are primarily detected by the ATM checkpoint pathway, where the…”
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PCNA Retention on DNA into G2/M Phase Causes Genome Instability in Cells Lacking Elg1 by Johnson, Catherine, Gali, Vamsi K., Takahashi, Tatsuro S., Kubota, Takashi

“…Loss of the genome maintenance factor Elg1 causes serious genome instability that leads to cancer, but the underlying mechanism is unknown. Elg1 forms the…”
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Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components by Kanke, Mai, Kodama, Yukako, Takahashi, Tatsuro S, Nakagawa, Takuro, Masukata, Hisao

“…The CMG complex composed of Mcm2‐7, Cdc45 and GINS is postulated to be the eukaryotic replicative DNA helicase, whose activation requires sequential…”
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The Atad5 RFC-like complex is the major unloader of proliferating cell nuclear antigen in Xenopus egg extracts by Kawasoe, Yoshitaka, Shimokawa, Sakiko, Gillespie, Peter J, Blow, J Julian, Tsurimoto, Toshiki, Takahashi, Tatsuro S

“…Proliferating cell nuclear antigen (PCNA) is a homo-trimeric clamp complex that serves as the molecular hub for various DNA transactions, including DNA…”
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The Prereplication Complex Recruits XEco2 to Chromatin to Promote Cohesin Acetylation in Xenopus Egg Extracts by Higashi, Torahiko L., Ikeda, Megumi, Tanaka, Hiroshi, Nakagawa, Takuro, Bando, Masashige, Shirahige, Katsuhiko, Kubota, Yumiko, Takisawa, Haruhiko, Masukata, Hisao, Takahashi, Tatsuro S.

“…Sister chromatids are held together by the ring-shaped cohesin complex, which is loaded onto chromosomes before DNA replication. Cohesion between sister…”
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Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1 by Terui, Riki, Nagao, Koji, Kawasoe, Yoshitaka, Taki, Kanae, Higashi, Torahiko L, Tanaka, Seiji, Nakagawa, Takuro, Obuse, Chikashi, Masukata, Hisao, Takahashi, Tatsuro S

“…Post-replicative correction of replication errors by the mismatch repair (MMR) system is critical for suppression of mutations. Although the MMR system may…”
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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication by Jones, Mathew J.K., Gelot, Camille, Munk, Stephanie, Koren, Amnon, Kawasoe, Yoshitaka, George, Kelly A., Santos, Ruth E., Olsen, Jesper V., McCarroll, Steven A., Frattini, Mark G., Takahashi, Tatsuro S., Jallepalli, Prasad V.

“…Eukaryotic genomes replicate via spatially and temporally regulated origin firing. Cyclin-dependent kinase (CDK) and Dbf4-dependent kinase (DDK) promote origin…”
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Shelterin promotes tethering of late replication origins to telomeres for replication‐timing control by Ogawa, Shiho, Kido, Sayuri, Handa, Tetsuya, Ogawa, Hidesato, Asakawa, Haruhiko, Takahashi, Tatsuro S, Nakagawa, Takuro, Hiraoka, Yasushi, Masukata, Hisao

“…DNA replication initiates at many discrete loci on eukaryotic chromosomes, and individual replication origins are regulated under a spatiotemporal program…”
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The heterochromatin protein Swi6/HP1 activates replication origins at the pericentromeric region and silent mating-type locus by Takahashi, Tatsuro S, Nakayama, Jun-ichi, Masukata, Hisao, Hayashi, Makoto T, Nakagawa, Takuro

“…Heterochromatin is a structurally compacted region of chromosomes in which transcription and recombination are inactivated. DNA replication is temporally…”
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Sister acts: coordinating DNA replication and cohesion establishment by Sherwood, Rebecca, Takahashi, Tatsuro S, Jallepalli, Prasad V

“…The ring-shaped cohesin complex links sister chromatids and plays crucial roles in homologous recombination and mitotic chromosome segregation. In cycling…”
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Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation by Onaka, Atsushi T, Toyofuku, Naoko, Inoue, Takahiro, Okita, Akiko K, Sagawa, Minami, Su, Jie, Shitanda, Takeshi, Matsuyama, Rei, Zafar, Faria, Takahashi, Tatsuro S, Masukata, Hisao, Nakagawa, Takuro

“…Centromeres consist of DNA repeats in many eukaryotes. Non-allelic homologous recombination (HR) between them can result in gross chromosomal rearrangements…”
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Regulation of mitotic recombination between DNA repeats in centromeres by Zafar, Faria, Okita, Akiko K, Onaka, Atsushi T, Su, Jie, Katahira, Yasuhiro, Nakayama, Jun-Ichi, Takahashi, Tatsuro S, Masukata, Hisao, Nakagawa, Takuro

“…Centromeres that are essential for faithful segregation of chromosomes consist of unique DNA repeats in many eukaryotes. Although recombination is…”
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Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast by Tazumi, Atsutoshi, Fukuura, Masayoshi, Nakato, Ryuichiro, Kishimoto, Ami, Takenaka, Tomokazu, Ogawa, Shiho, Song, Ji-Hoon, Takahashi, Tatsuro S, Nakagawa, Takuro, Shirahige, Katsuhiko, Masukata, Hisao

“…In eukaryotes, the replication of chromosome DNA is coordinated by a replication timing program that temporally regulates the firing of individual replication…”
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Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway by Kato, Niyo, Kawasoe, Yoshitaka, Williams, Hannah, Coates, Elena, Roy, Upasana, Shi, Yuqian, Beese, Lorena S., Schärer, Orlando D., Yan, Hong, Gottesman, Max E., Takahashi, Tatsuro S., Gautier, Jean

“…DNA interstrand crosslinks (ICLs) that are repaired in non-dividing cells must be recognized independently of replication-associated DNA unwinding. Using…”
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The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5 by Miyashita, Ryota, Nishiyama, Atsuya, Qin, Weihua, Chiba, Yoshie, Kori, Satomi, Kato, Norie, Konishi, Chieko, Kumamoto, Soichiro, Kozuka-Hata, Hiroko, Oyama, Masaaki, Kawasoe, Yoshitaka, Tsurimoto, Toshiki, Takahashi, Tatsuro S, Leonhardt, Heinrich, Arita, Kyohei, Nakanishi, Makoto

“…UHRF1-dependent ubiquitin signaling plays an integral role in the regulation of maintenance DNA methylation. UHRF1 catalyzes transient dual mono-ubiquitylation…”
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DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast by Handa, Tetsuya, Kanke, Mai, Takahashi, Tatsuro S, Nakagawa, Takuro, Masukata, Hisao

“…DNA polymerase epsilon (Pol ε) synthesizes the leading strands, following the CMG (Cdc45, Mcm2-7, and GINS [Go-Ichi-Nii-San]) helicase that translocates on the…”
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MutSα maintains the mismatch repair capability by inhibiting PCNA unloading by Kawasoe, Yoshitaka, Tsurimoto, Toshiki, Nakagawa, Takuro, Masukata, Hisao, Takahashi, Tatsuro S

“…Eukaryotic mismatch repair (MMR) utilizes single-strand breaks as signals to target the strand to be repaired. DNA-bound PCNA is also presumed to direct MMR…”
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Cdc7-Drf1 kinase links chromosome cohesion to the initiation of DNA replication in Xenopus egg extracts by Takahashi, Tatsuro S, Basu, Abhijit, Bermudez, Vladimir, Hurwitz, Jerard, Walter, Johannes C

“…To establish functional cohesion between replicated sister chromatids, cohesin is recruited to chromatin before S phase. Cohesin is loaded onto chromosomes in…”
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Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide by Fuchs, Robert P, Isogawa, Asako, Paulo, Joao A, Onizuka, Kazumitsu, Takahashi, Tatsuro, Amunugama, Ravindra, Duxin, Julien P, Fujii, Shingo

“…Temozolomide (TMZ), a DNA methylating agent, is the primary chemotherapeutic drug used in glioblastoma treatment. TMZ induces mostly N-alkylation adducts…”
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