Search Results - "TAKAHASHI, Takamune"

The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential by Fujita, Hiroki, Morii, Tsukasa, Fujishima, Hiromi, Sato, Takehiro, Shimizu, Tatsunori, Hosoba, Mihoko, Tsukiyama, Katsushi, Narita, Takuma, Takahashi, Takamune, Drucker, Daniel J, Seino, Yutaka, Yamada, Yuichiro

“…Glucagon-like peptide-1 (GLP-1) is a gut incretin hormone that has an antioxidative protective effect on various tissues. Here, we determined whether GLP-1 has…”
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Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II–Induced Hypertension by Xiao, Liang, Kirabo, Annet, Wu, Jing, Saleh, Mohamed A, Zhu, Linjue, Wang, Feng, Takahashi, Takamune, Loperena, Roxana, Foss, Jason D, Mernaugh, Raymond L, Chen, Wei, Roberts, Jackson, Osborn, John W, Itani, Hana A, Harrison, David G

“…RATIONALE:Inflammation and adaptive immunity play a crucial role in the development of hypertension. Angiotensin II and probably other hypertensive stimuli…”
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Stromal cell-derived factor-1 is upregulated by dipeptidyl peptidase-4 inhibition and has protective roles in progressive diabetic nephropathy by Takashima, Satoru, Fujita, Hiroki, Fujishima, Hiromi, Shimizu, Tatsunori, Sato, Takehiro, Morii, Tsukasa, Tsukiyama, Katsushi, Narita, Takuma, Takahashi, Takamune, Drucker, Daniel J, Seino, Yutaka, Yamada, Yuichiro

“…The role of stromal cell-derived factor-1 (SDF-1) in the pathogenesis of diabetic nephropathy and its modification by dipeptidyl peptidase-4 (DPP-4) inhibition…”
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Clinical and experimental approaches for imaging of acute kidney injury by Katagiri, Daisuke, Wang, Feng, Gore, John C., Harris, Raymond C., Takahashi, Takamune

“…Complex molecular cell dynamics in acute kidney injury and its heterogeneous etiologies in patient populations in clinical settings have revealed the potential…”
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Role of Endothelial Nitric Oxide Synthase in Diabetic Nephropathy: Lessons from Diabetic eNOS Knockout Mice by Takahashi, Takamune, Harris, Raymond C.

“…Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in many countries. The animal models that recapitulate human DN undoubtedly…”
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Critical Role for Hepatocyte-Specific eNOS in NAFLD and NASH by Cunningham, Rory P, Moore, Mary P, Dashek, Ryan J, Meers, Grace M, Takahashi, Takamune, Sheldon, Ryan D, Wheeler, Andrew A, Diaz-Arias, Alberto, Ibdah, Jamal A, Parks, Elizabeth J, Thyfault, John P, Rector, R Scott

“…Regulation of endothelial nitric oxide synthase (eNOS) in hepatocytes may be an important target in nonalcoholic fatty liver disease (NAFLD) development and…”
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Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice by ZHAO, Hui John, SUWAN WANG, HUIFANG CHENG, ZHANG, Ming-Zhi, TAKAHASHI, Takamune, FOGO, Agnes B, BREYER, Matthew D, HARRIS, Raymond C

“…Functionally significant polymorphisms in endothelial nitric oxide synthase (eNOS) and reduced vascular eNOS activity have been associated with increased human…”
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Reduction of Renal Superoxide Dismutase in Progressive Diabetic Nephropathy by FUJITA, Hiroki, FUJISHIMA, Hiromi, CHIDA, Shinsuke, TAKAHASHI, Keiko, ZHONGHUA QI, KANETSUNA, Yukiko, BREYER, Matthew D, HARRIS, Raymond C, YAMADA, Yuichiro, TAKAHASHI, Takamune

“…Superoxide excess plays a central role in tissue damage that results from diabetes, but the mechanisms of superoxide overproduction in diabetic nephropathy…”
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Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism by Fang, Wei Bin, Ireton, Reneé C, Zhuang, Guanglei, Takahashi, Takamune, Reynolds, Al, Chen, Jin

“…EPHA2 receptor tyrosine kinase is overexpressed in several human cancer types and promotes malignancy. However, the mechanisms by which EPHA2 promotes tumor…”
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Deficiency of Endothelial Nitric-Oxide Synthase Confers Susceptibility to Diabetic Nephropathy in Nephropathy-Resistant Inbred Mice by Kanetsuna, Yukiko, Takahashi, Keiko, Nagata, Michio, Gannon, Maureen A, Breyer, Matthew D, Harris, Raymond C, Takahashi, Takamune

“…Recent studies have implicated dysfunctional endothelial nitric-oxide synthase (eNOS) as a common pathogenic pathway in diabetic vascular complications…”
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The effects of CD148 Q276P/R326Q polymorphisms in A431D epidermoid cancer cell proliferation and epidermal growth factor receptor signaling by He, Lilly, Takahashi, Keiko, Pasic, Lejla, Narui, Chikage, Ellinger, Philipp, Grundmann, Manuel, Takahashi, Takamune

“…Background CD148 is a transmembrane protein tyrosine phosphatase that is expressed in multiple cell types. Previous studies have shown that CD148…”
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Determination of the CD148-Interacting Region in Thrombospondin-1 by Takahashi, Keiko, Sumarriva, Katherine, Kim, Rachel, Jiang, Rosie, Brantley-Sieders, Dana M, Chen, Jin, Mernaugh, Raymond L, Takahashi, Takamune

“…CD148 is a transmembrane protein tyrosine phosphatase that is expressed in multiple cell types, including vascular endothelial cells and duct epithelial cells…”
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Thrombospondin-1 acts as a ligand for CD148 tyrosine phosphatase by Takahashi, Keiko, Mernaugh, Raymond L., Friedman, David B., Weller, Rebecca, Tsuboi, Nobuo, Yamashita, Hironobu, Quaranta, Vito, Takahashi, Takamune

“…CD148 is a receptor-type protein tyrosine phosphatase that is expressed in several cell types, including vascular endothelial cells and duct epithelial cells…”
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CD148 tyrosine phosphatase promotes cadherin cell adhesion by Takahashi, Keiko, Matafonov, Anton, Sumarriva, Katherine, Ito, Hideyuki, Lauhan, Colette, Zemel, Dana, Tsuboi, Nobuo, Chen, Jin, Reynolds, Albert, Takahashi, Takamune

“…CD148 is a transmembrane tyrosine phosphatase that is expressed at cell junctions. Recent studies have shown that CD148 associates with the cadherin/catenin…”
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Tumor Suppressor Density-enhanced Phosphatase-1 (DEP-1) Inhibits the RAS Pathway by Direct Dephosphorylation of ERK1/2 Kinases by Sacco, Francesca, Tinti, Michele, Palma, Anita, Ferrari, Emanuela, Nardozza, Aurelio P., van Huijsduijnen, Rob Hooft, Takahashi, Takamune, Castagnoli, Luisa, Cesareni, Gianni

“…Density-enhanced phosphatase-1 (DEP-1) is a trans-membrane receptor protein-tyrosine phosphatase that plays a recognized prominent role as a tumor suppressor…”
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Current MRI techniques for the assessment of renal disease by Takahashi, Takamune, Wang, Feng, Quarles, Christopher C.

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Expression of receptor-type protein tyrosine phosphatase in developing and adult renal vasculature by Takahashi, Keiko, Kim, Rachel, Lauhan, Colette, Park, Yuna, Nguyen, Nghiep G, Vestweber, Dietmar, Dominguez, Melissa G, Valenzuela, David M, Murphy, Andrew J, Yancopoulos, George D, Gale, Nicholas W, Takahashi, Takamune

“…Renal vascular development is a coordinated process that requires ordered endothelial cell proliferation, migration, intercellular adhesion, and morphogenesis…”
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Modulation of renal superoxide dismutase by telmisartan therapy in C57BL/6-Ins2(Akita) diabetic mice by Fujita, Hiroki, Fujishima, Hiromi, Morii, Tsukasa, Sakamoto, Takuya, Komatsu, Koga, Hosoba, Mihoko, Narita, Takuma, Takahashi, Keiko, Takahashi, Takamune, Yamada, Yuichiro

“…Renal superoxide excess, which is induced by an imbalance of the superoxide-producing enzyme NAD(P)H oxidase and the superoxide-scavenging enzyme superoxide…”
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Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes by JING CHEN, BOYLE, Scott, MIN ZHAO, WEI SU, TAKAHASHI, Keiko, DAVIS, Linda, DECAESTECKER, Mark, TAKAHASHI, Takamune, BREYER, Matthew D, HAO, Chuan-Ming

“…Nestin, an intermediate filament protein, is widely used as stem cell marker. Nestin has been shown to interact with other cytoskeleton proteins, suggesting a…”
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Reduction of circulating superoxide dismutase activity in type 2 diabetic patients with microalbuminuria and its modulation by telmisartan therapy by Fujita, Hiroki, Sakamoto, Takuya, Komatsu, Koga, Fujishima, Hiromi, Morii, Tsukasa, Narita, Takuma, Takahashi, Takamune, Yamada, Yuichiro

“…Growing evidence indicates that oxidative stress induced by excessive superoxide has a central role in the pathogenesis of diabetic nephropathy (DN)…”
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